Probiotic Monotherapy with Lactobacillus reuteri (Prodentis) as a Coadjutant to Reduce Subgingival Dysbiosis in a Patient with Periodontitis
(1) Background: Probiotics can be considered a non-invasive periodontal monotherapy for the modulation of microbiota when periodontal treatment is not accessible. The aim was to evaluate the ability of Lactobacillus reuteri Prodentis as monotherapy to modulate periodontal parameters and subgingival...
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| Veröffentlicht in: | International journal of environmental research and public health 2022-06, Vol.19 (13), p.7835 |
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| creator | Salinas-Azuceno, Claudia Martínez-Hernández, Miryam Maldonado-Noriega, José-Isaac Rodríguez-Hernández, Adriana-Patricia Ximenez-Fyvie, Laurie-Ann |
| description | (1) Background: Probiotics can be considered a non-invasive periodontal monotherapy for the modulation of microbiota when periodontal treatment is not accessible. The aim was to evaluate the ability of Lactobacillus reuteri Prodentis as monotherapy to modulate periodontal parameters and subgingival biofilm dysbiosis. (2) Methods: A 30-year-old patient with periodontitis was followed longitudinally after one month of daily consumption of L. reuteri Prodentis (T0). Periodontal measurements and microbial identification by Checkerboard DNA−DNA hybridization of 40 bacteria were compared between baseline (T0) and 30 days (T1) or 90 days (T2), using the Kruskal−Wallis (KW) and Mann−Whitney U (MW) tests. (3) Results: Low values of pocket depth, attachment level, dental plaque, gingival erythema (GE), and suppuration were observed at T0 vs. T1, with the clinical improvement of GE (p < 0.05, MW) and the recovery of tooth 46 fistulation. T1 vs. T0 comparisons showed lower levels (Lev) or proportions (Prop) of Parvimonas micra (Lev: p < 0.05, MW; Prop: p < 0.01, MW) and Streptococcus gordonii (Prop: p < 0.05, MW), and a predominance (Lev/Prop) of Actinomyces odontolyticus and Streptococcus mitis; lower levels and proportions of P. micra, Eubacterium saburreum, Porphyromonas gingivalis, and Tannerella forsythia were observed in tooth 46 (T1/T2 vs. T0). (4) Conclusions: Under monotherapy with L. reuteri Prodentis, periodontal measurements of the patient were maintained, with selective changes in the subgingival microbiota that were proportional to the time of probiotic administration, with any additional periodontal treatment. |
| doi_str_mv | 10.3390/ijerph19137835 |
| format | Article |
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The aim was to evaluate the ability of Lactobacillus reuteri Prodentis as monotherapy to modulate periodontal parameters and subgingival biofilm dysbiosis. (2) Methods: A 30-year-old patient with periodontitis was followed longitudinally after one month of daily consumption of L. reuteri Prodentis (T0). Periodontal measurements and microbial identification by Checkerboard DNA−DNA hybridization of 40 bacteria were compared between baseline (T0) and 30 days (T1) or 90 days (T2), using the Kruskal−Wallis (KW) and Mann−Whitney U (MW) tests. (3) Results: Low values of pocket depth, attachment level, dental plaque, gingival erythema (GE), and suppuration were observed at T0 vs. T1, with the clinical improvement of GE (p < 0.05, MW) and the recovery of tooth 46 fistulation. T1 vs. T0 comparisons showed lower levels (Lev) or proportions (Prop) of Parvimonas micra (Lev: p < 0.05, MW; Prop: p < 0.01, MW) and Streptococcus gordonii (Prop: p < 0.05, MW), and a predominance (Lev/Prop) of Actinomyces odontolyticus and Streptococcus mitis; lower levels and proportions of P. micra, Eubacterium saburreum, Porphyromonas gingivalis, and Tannerella forsythia were observed in tooth 46 (T1/T2 vs. T0). (4) Conclusions: Under monotherapy with L. reuteri Prodentis, periodontal measurements of the patient were maintained, with selective changes in the subgingival microbiota that were proportional to the time of probiotic administration, with any additional periodontal treatment.</description><identifier>ISSN: 1660-4601</identifier><identifier>ISSN: 1661-7827</identifier><identifier>EISSN: 1660-4601</identifier><identifier>DOI: 10.3390/ijerph19137835</identifier><identifier>PMID: 35805491</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Adult ; Bacteria ; Biofilms ; Case Report ; Dental plaque ; Deoxyribonucleic acid ; Disease prevention ; DNA ; Dysbacteriosis ; Dysbiosis - therapy ; Erythema ; Ethics ; Gingiva ; Gum disease ; Humans ; Hybridization ; Lactobacillus reuteri ; Limosilactobacillus reuteri ; Microbiota ; Microorganisms ; Pathogens ; Patients ; Periodontitis ; Periodontitis - microbiology ; Periodontitis - therapy ; Porphyromonas gingivalis ; Probiotics ; Probiotics - therapeutic use ; Systemic diseases ; Teeth</subject><ispartof>International journal of environmental research and public health, 2022-06, Vol.19 (13), p.7835</ispartof><rights>2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2022 by the authors. 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c315t-883539f8b969741de3a0aa3e424acb80a07ba814ef10dac349a0ebc888fb34a03</citedby><cites>FETCH-LOGICAL-c315t-883539f8b969741de3a0aa3e424acb80a07ba814ef10dac349a0ebc888fb34a03</cites><orcidid>0000-0002-1589-8605 ; 0000-0002-9473-1749 ; 0000-0003-4370-0843 ; 0000-0002-9357-477X ; 0000-0002-8667-7818</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9265494/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9265494/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27922,27923,53789,53791</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35805491$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Salinas-Azuceno, Claudia</creatorcontrib><creatorcontrib>Martínez-Hernández, Miryam</creatorcontrib><creatorcontrib>Maldonado-Noriega, José-Isaac</creatorcontrib><creatorcontrib>Rodríguez-Hernández, Adriana-Patricia</creatorcontrib><creatorcontrib>Ximenez-Fyvie, Laurie-Ann</creatorcontrib><title>Probiotic Monotherapy with Lactobacillus reuteri (Prodentis) as a Coadjutant to Reduce Subgingival Dysbiosis in a Patient with Periodontitis</title><title>International journal of environmental research and public health</title><addtitle>Int J Environ Res Public Health</addtitle><description>(1) Background: Probiotics can be considered a non-invasive periodontal monotherapy for the modulation of microbiota when periodontal treatment is not accessible. The aim was to evaluate the ability of Lactobacillus reuteri Prodentis as monotherapy to modulate periodontal parameters and subgingival biofilm dysbiosis. (2) Methods: A 30-year-old patient with periodontitis was followed longitudinally after one month of daily consumption of L. reuteri Prodentis (T0). Periodontal measurements and microbial identification by Checkerboard DNA−DNA hybridization of 40 bacteria were compared between baseline (T0) and 30 days (T1) or 90 days (T2), using the Kruskal−Wallis (KW) and Mann−Whitney U (MW) tests. (3) Results: Low values of pocket depth, attachment level, dental plaque, gingival erythema (GE), and suppuration were observed at T0 vs. T1, with the clinical improvement of GE (p < 0.05, MW) and the recovery of tooth 46 fistulation. T1 vs. T0 comparisons showed lower levels (Lev) or proportions (Prop) of Parvimonas micra (Lev: p < 0.05, MW; Prop: p < 0.01, MW) and Streptococcus gordonii (Prop: p < 0.05, MW), and a predominance (Lev/Prop) of Actinomyces odontolyticus and Streptococcus mitis; lower levels and proportions of P. micra, Eubacterium saburreum, Porphyromonas gingivalis, and Tannerella forsythia were observed in tooth 46 (T1/T2 vs. T0). (4) Conclusions: Under monotherapy with L. reuteri Prodentis, periodontal measurements of the patient were maintained, with selective changes in the subgingival microbiota that were proportional to the time of probiotic administration, with any additional periodontal treatment.</description><subject>Adult</subject><subject>Bacteria</subject><subject>Biofilms</subject><subject>Case Report</subject><subject>Dental plaque</subject><subject>Deoxyribonucleic acid</subject><subject>Disease prevention</subject><subject>DNA</subject><subject>Dysbacteriosis</subject><subject>Dysbiosis - therapy</subject><subject>Erythema</subject><subject>Ethics</subject><subject>Gingiva</subject><subject>Gum disease</subject><subject>Humans</subject><subject>Hybridization</subject><subject>Lactobacillus reuteri</subject><subject>Limosilactobacillus reuteri</subject><subject>Microbiota</subject><subject>Microorganisms</subject><subject>Pathogens</subject><subject>Patients</subject><subject>Periodontitis</subject><subject>Periodontitis - microbiology</subject><subject>Periodontitis - therapy</subject><subject>Porphyromonas gingivalis</subject><subject>Probiotics</subject><subject>Probiotics - therapeutic use</subject><subject>Systemic diseases</subject><subject>Teeth</subject><issn>1660-4601</issn><issn>1661-7827</issn><issn>1660-4601</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNpVkUtvGyEUhVHUqEncbrOskLpJFk7AMBg2lSLn0UiOavWxRheGsbHGgwNMIv-H_OgQOY3sFUic851zuQidUnLBmCKXfuniekEVZWPJqgN0TIUgQy4I_bRzP0InKS0JYZIL9RkdsUqSiit6jF5mMRgfsrf4IXQhL1yE9QY_-7zAU7A5GLC-bfuEo-uzix6fFUftuuzTOYaEAU8C1Ms-Q5dxDvi3q3vr8J_ezH0390_Q4utNKhHJJ-y7op9B9sW_zZgVZKhDwRXgF3TYQJvc1_dzgP7d3vyd_BxOf93dT66mQ8tolYeyTMpUI40Sasxp7RgQAOb4iIM1kgAZG5CUu4aSGizjCogzVkrZGMaBsAH6seWue7NytS1tIrR6Hf0K4kYH8Hr_pfMLPQ9PWo1E-TZeAN_fATE89i5lvQx97EpnPRJSEFVRJorqYquyMaQUXfORQIl-257e314xfNvt9SH_vy72Co6HmvQ</recordid><startdate>20220626</startdate><enddate>20220626</enddate><creator>Salinas-Azuceno, Claudia</creator><creator>Martínez-Hernández, Miryam</creator><creator>Maldonado-Noriega, José-Isaac</creator><creator>Rodríguez-Hernández, Adriana-Patricia</creator><creator>Ximenez-Fyvie, Laurie-Ann</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>COVID</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-1589-8605</orcidid><orcidid>https://orcid.org/0000-0002-9473-1749</orcidid><orcidid>https://orcid.org/0000-0003-4370-0843</orcidid><orcidid>https://orcid.org/0000-0002-9357-477X</orcidid><orcidid>https://orcid.org/0000-0002-8667-7818</orcidid></search><sort><creationdate>20220626</creationdate><title>Probiotic Monotherapy with Lactobacillus reuteri (Prodentis) as a Coadjutant to Reduce Subgingival Dysbiosis in a Patient with Periodontitis</title><author>Salinas-Azuceno, Claudia ; Martínez-Hernández, Miryam ; Maldonado-Noriega, José-Isaac ; Rodríguez-Hernández, Adriana-Patricia ; Ximenez-Fyvie, Laurie-Ann</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c315t-883539f8b969741de3a0aa3e424acb80a07ba814ef10dac349a0ebc888fb34a03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Adult</topic><topic>Bacteria</topic><topic>Biofilms</topic><topic>Case Report</topic><topic>Dental plaque</topic><topic>Deoxyribonucleic acid</topic><topic>Disease prevention</topic><topic>DNA</topic><topic>Dysbacteriosis</topic><topic>Dysbiosis - therapy</topic><topic>Erythema</topic><topic>Ethics</topic><topic>Gingiva</topic><topic>Gum disease</topic><topic>Humans</topic><topic>Hybridization</topic><topic>Lactobacillus reuteri</topic><topic>Limosilactobacillus reuteri</topic><topic>Microbiota</topic><topic>Microorganisms</topic><topic>Pathogens</topic><topic>Patients</topic><topic>Periodontitis</topic><topic>Periodontitis - microbiology</topic><topic>Periodontitis - therapy</topic><topic>Porphyromonas gingivalis</topic><topic>Probiotics</topic><topic>Probiotics - therapeutic use</topic><topic>Systemic diseases</topic><topic>Teeth</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Salinas-Azuceno, Claudia</creatorcontrib><creatorcontrib>Martínez-Hernández, Miryam</creatorcontrib><creatorcontrib>Maldonado-Noriega, José-Isaac</creatorcontrib><creatorcontrib>Rodríguez-Hernández, Adriana-Patricia</creatorcontrib><creatorcontrib>Ximenez-Fyvie, Laurie-Ann</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Coronavirus Research Database</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of environmental research and public health</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Salinas-Azuceno, Claudia</au><au>Martínez-Hernández, Miryam</au><au>Maldonado-Noriega, José-Isaac</au><au>Rodríguez-Hernández, Adriana-Patricia</au><au>Ximenez-Fyvie, Laurie-Ann</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Probiotic Monotherapy with Lactobacillus reuteri (Prodentis) as a Coadjutant to Reduce Subgingival Dysbiosis in a Patient with Periodontitis</atitle><jtitle>International journal of environmental research and public health</jtitle><addtitle>Int J Environ Res Public Health</addtitle><date>2022-06-26</date><risdate>2022</risdate><volume>19</volume><issue>13</issue><spage>7835</spage><pages>7835-</pages><issn>1660-4601</issn><issn>1661-7827</issn><eissn>1660-4601</eissn><abstract>(1) Background: Probiotics can be considered a non-invasive periodontal monotherapy for the modulation of microbiota when periodontal treatment is not accessible. The aim was to evaluate the ability of Lactobacillus reuteri Prodentis as monotherapy to modulate periodontal parameters and subgingival biofilm dysbiosis. (2) Methods: A 30-year-old patient with periodontitis was followed longitudinally after one month of daily consumption of L. reuteri Prodentis (T0). Periodontal measurements and microbial identification by Checkerboard DNA−DNA hybridization of 40 bacteria were compared between baseline (T0) and 30 days (T1) or 90 days (T2), using the Kruskal−Wallis (KW) and Mann−Whitney U (MW) tests. (3) Results: Low values of pocket depth, attachment level, dental plaque, gingival erythema (GE), and suppuration were observed at T0 vs. T1, with the clinical improvement of GE (p < 0.05, MW) and the recovery of tooth 46 fistulation. T1 vs. T0 comparisons showed lower levels (Lev) or proportions (Prop) of Parvimonas micra (Lev: p < 0.05, MW; Prop: p < 0.01, MW) and Streptococcus gordonii (Prop: p < 0.05, MW), and a predominance (Lev/Prop) of Actinomyces odontolyticus and Streptococcus mitis; lower levels and proportions of P. micra, Eubacterium saburreum, Porphyromonas gingivalis, and Tannerella forsythia were observed in tooth 46 (T1/T2 vs. T0). (4) Conclusions: Under monotherapy with L. reuteri Prodentis, periodontal measurements of the patient were maintained, with selective changes in the subgingival microbiota that were proportional to the time of probiotic administration, with any additional periodontal treatment.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>35805491</pmid><doi>10.3390/ijerph19137835</doi><orcidid>https://orcid.org/0000-0002-1589-8605</orcidid><orcidid>https://orcid.org/0000-0002-9473-1749</orcidid><orcidid>https://orcid.org/0000-0003-4370-0843</orcidid><orcidid>https://orcid.org/0000-0002-9357-477X</orcidid><orcidid>https://orcid.org/0000-0002-8667-7818</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Bacteria Biofilms Case Report Dental plaque Deoxyribonucleic acid Disease prevention DNA Dysbacteriosis Dysbiosis - therapy Erythema Ethics Gingiva Gum disease Humans Hybridization Lactobacillus reuteri Limosilactobacillus reuteri Microbiota Microorganisms Pathogens Patients Periodontitis Periodontitis - microbiology Periodontitis - therapy Porphyromonas gingivalis Probiotics Probiotics - therapeutic use Systemic diseases Teeth |
| title | Probiotic Monotherapy with Lactobacillus reuteri (Prodentis) as a Coadjutant to Reduce Subgingival Dysbiosis in a Patient with Periodontitis |
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