The Combination of Δ9-Tetrahydrocannabinol and Cannabidiol Suppresses Mitochondrial Respiration of Human Glioblastoma Cells via Downregulation of Specific Respiratory Chain Proteins

Phytocannabinoids represent a promising approach in glioblastoma therapy. Previous work has shown that a combined treatment of glioblastoma cells with submaximal effective concentrations of psychoactive Δ9-tetrahydrocannabinol (THC) and non-psychoactive cannabidiol (CBD) greatly increases cell death...

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Veröffentlicht in:	Cancers 2022-06, Vol.14 (13), p.3129
Hauptverfasser:	Rupprecht, Anne, Theisen, Ulrike, Wendt, Franziska, Frank, Marcus, Hinz, Burkhard
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Apoptosis Autophagy Cancer Cancer therapies Cannabidiol Cannabinoid CB1 receptors Cannabinoid CB2 receptors Cannabinoids Cannabis Capsaicin receptors Cell culture Cell death Cell survival Cyclooxygenase-2 Cytochrome c Cytosol Electron transfer Electron transport chain Energy metabolism Ethanol Glioblastoma Glioblastoma cells Medical research Mitochondria Oxygen consumption Phenols Proteasomes Proteins Respiration Tetrahydrocannabinol THC
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