Effect of Alpha-Lipoic Acid in the Treatment of Diabetic Neuropathy: A Systematic Review
Diabetic neuropathy is a clinical condition that can have a significant impact on quality of life, presenting as numbness, tingling, and burning in the extremities. Current treatment options focus on symptom alleviation and reducing exposure to risk factors as treating the pathophysiological causes...
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| Veröffentlicht in: | Curēus (Palo Alto, CA) CA), 2022-06, Vol.14 (6), p.e25750 |
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| creator | Abubaker, Saleh A Alonazy, Abdulaziz M Abdulrahman, Albasseet |
| description | Diabetic neuropathy is a clinical condition that can have a significant impact on quality of life, presenting as numbness, tingling, and burning in the extremities. Current treatment options focus on symptom alleviation and reducing exposure to risk factors as treating the pathophysiological causes of diabetic neuropathy remains a significant challenge. Novel studies have proposed that the use of antioxidants, including alpha-lipoic acid (⍺-lipoic acid), may represent a beneficial intervention for treating neuropathic pain in diabetic patients. This study aims to evaluate the effect of ⍺-lipoic acid in the treatment of diabetic neuropathy and determine its effectiveness in reducing the symptoms of diabetic neuropathy. To achieve our objective, PubMed, Scopus, and Web of Science databases were screened on March 3, 2022. Randomized controlled trials that investigated ⍺-lipoic acid treatment in diabetes mellitus patients with neuropathic pain and made an appropriate comparison were included. The reduction of neuropathic symptoms was the primary outcome, and the secondary outcome was the incidence of adverse events. Eight studies comprising 1,500 diabetic patients were evaluated in this systematic review. The findings were inconsistent among the literature concerning the effectiveness of ⍺-lipoic acid in the treatment of diabetic neuropathy, with three trials (37.5%) observing significant improvements in symptoms and five trials (62.5%) not observing any notable results. All studies found ⍺-lipoic acid to be a safe and tolerable intervention, with no reported adverse effects. The administration of ⍺-lipoic acid may result in symptom reduction and offers a safe and tolerable treatment option. However, there is limited evidence to support the beneficial outcomes of this approach. Further trials are warranted to corroborate or contradict the hypothesis that ⍺-lipoic acid is an effective intervention for the treatment of diabetic neuropathy. |
| doi_str_mv | 10.7759/cureus.25750 |
| format | Article |
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Current treatment options focus on symptom alleviation and reducing exposure to risk factors as treating the pathophysiological causes of diabetic neuropathy remains a significant challenge. Novel studies have proposed that the use of antioxidants, including alpha-lipoic acid (⍺-lipoic acid), may represent a beneficial intervention for treating neuropathic pain in diabetic patients. This study aims to evaluate the effect of ⍺-lipoic acid in the treatment of diabetic neuropathy and determine its effectiveness in reducing the symptoms of diabetic neuropathy. To achieve our objective, PubMed, Scopus, and Web of Science databases were screened on March 3, 2022. Randomized controlled trials that investigated ⍺-lipoic acid treatment in diabetes mellitus patients with neuropathic pain and made an appropriate comparison were included. The reduction of neuropathic symptoms was the primary outcome, and the secondary outcome was the incidence of adverse events. Eight studies comprising 1,500 diabetic patients were evaluated in this systematic review. The findings were inconsistent among the literature concerning the effectiveness of ⍺-lipoic acid in the treatment of diabetic neuropathy, with three trials (37.5%) observing significant improvements in symptoms and five trials (62.5%) not observing any notable results. All studies found ⍺-lipoic acid to be a safe and tolerable intervention, with no reported adverse effects. The administration of ⍺-lipoic acid may result in symptom reduction and offers a safe and tolerable treatment option. However, there is limited evidence to support the beneficial outcomes of this approach. Further trials are warranted to corroborate or contradict the hypothesis that ⍺-lipoic acid is an effective intervention for the treatment of diabetic neuropathy.</description><identifier>ISSN: 2168-8184</identifier><identifier>EISSN: 2168-8184</identifier><identifier>DOI: 10.7759/cureus.25750</identifier><identifier>PMID: 35812639</identifier><language>eng</language><publisher>United States: Cureus Inc</publisher><subject>Acids ; Antidepressants ; Bias ; Clinical trials ; Data collection ; Diabetes ; Diabetic neuropathy ; Drug dosages ; Endocrinology/Diabetes/Metabolism ; Evidence-based medicine ; Family/General Practice ; Intervention ; Pain ; Pain Management ; Peripheral neuropathy ; Systematic review</subject><ispartof>Curēus (Palo Alto, CA), 2022-06, Vol.14 (6), p.e25750</ispartof><rights>Copyright © 2022, Abubaker et al.</rights><rights>Copyright © 2022, Abubaker et al. This work is published under https://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Copyright © 2022, Abubaker et al. 2022 Abubaker et al.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c342t-7567f322232f1f7105995994d2e16df39cf3f909467d6a2e9bbbf416d9ad4db3</citedby><cites>FETCH-LOGICAL-c342t-7567f322232f1f7105995994d2e16df39cf3f909467d6a2e9bbbf416d9ad4db3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9264721/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9264721/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35812639$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Abubaker, Saleh A</creatorcontrib><creatorcontrib>Alonazy, Abdulaziz M</creatorcontrib><creatorcontrib>Abdulrahman, Albasseet</creatorcontrib><title>Effect of Alpha-Lipoic Acid in the Treatment of Diabetic Neuropathy: A Systematic Review</title><title>Curēus (Palo Alto, CA)</title><addtitle>Cureus</addtitle><description>Diabetic neuropathy is a clinical condition that can have a significant impact on quality of life, presenting as numbness, tingling, and burning in the extremities. 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Eight studies comprising 1,500 diabetic patients were evaluated in this systematic review. The findings were inconsistent among the literature concerning the effectiveness of ⍺-lipoic acid in the treatment of diabetic neuropathy, with three trials (37.5%) observing significant improvements in symptoms and five trials (62.5%) not observing any notable results. All studies found ⍺-lipoic acid to be a safe and tolerable intervention, with no reported adverse effects. The administration of ⍺-lipoic acid may result in symptom reduction and offers a safe and tolerable treatment option. However, there is limited evidence to support the beneficial outcomes of this approach. Further trials are warranted to corroborate or contradict the hypothesis that ⍺-lipoic acid is an effective intervention for the treatment of diabetic neuropathy.</description><subject>Acids</subject><subject>Antidepressants</subject><subject>Bias</subject><subject>Clinical trials</subject><subject>Data collection</subject><subject>Diabetes</subject><subject>Diabetic neuropathy</subject><subject>Drug dosages</subject><subject>Endocrinology/Diabetes/Metabolism</subject><subject>Evidence-based medicine</subject><subject>Family/General Practice</subject><subject>Intervention</subject><subject>Pain</subject><subject>Pain Management</subject><subject>Peripheral neuropathy</subject><subject>Systematic review</subject><issn>2168-8184</issn><issn>2168-8184</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNpdkc1rFTEUxYNYbKnduZYBNy6cmq_JhwvhUdsqPFrQt3AXMpkbX8rMZExmKu-_N-2rpRYu3Avnx-EeDkJvCD6VstEf3ZJgyae0kQ1-gY4oEapWRPGXT-5DdJLzDcaYYEmxxK_QIWsUoYLpI_Tz3HtwcxV9teqnra3XYYrBVSsXuiqM1byFapPAzgOM99SXYFuYC3EFS4qTnbe7T9Wq-rHLMwz2TvgOtwH-vEYH3vYZTh72MdpcnG_Ovtbr68tvZ6t17Rincy0bIT2jlDLqiZcEN1qX4R0FIjrPtPPMa6y5kJ2wFHTbtp4XSduOdy07Rp_3ttPSDtC58mWyvZlSGGzamWiD-V8Zw9b8irdGU8ElJcXg_YNBir8XyLMZQnbQ93aEuGRDhVJYacFpQd89Q2_iksaSrlBaSKW4agr1YU-5FHNO4B-fIdjclWb2pZn70gr-9mmAR_hfRewvHOKTJg</recordid><startdate>20220608</startdate><enddate>20220608</enddate><creator>Abubaker, Saleh A</creator><creator>Alonazy, Abdulaziz M</creator><creator>Abdulrahman, Albasseet</creator><general>Cureus Inc</general><general>Cureus</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20220608</creationdate><title>Effect of Alpha-Lipoic Acid in the Treatment of Diabetic Neuropathy: A Systematic Review</title><author>Abubaker, Saleh A ; Alonazy, Abdulaziz M ; Abdulrahman, Albasseet</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c342t-7567f322232f1f7105995994d2e16df39cf3f909467d6a2e9bbbf416d9ad4db3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Acids</topic><topic>Antidepressants</topic><topic>Bias</topic><topic>Clinical trials</topic><topic>Data collection</topic><topic>Diabetes</topic><topic>Diabetic neuropathy</topic><topic>Drug dosages</topic><topic>Endocrinology/Diabetes/Metabolism</topic><topic>Evidence-based medicine</topic><topic>Family/General Practice</topic><topic>Intervention</topic><topic>Pain</topic><topic>Pain Management</topic><topic>Peripheral neuropathy</topic><topic>Systematic review</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Abubaker, Saleh A</creatorcontrib><creatorcontrib>Alonazy, Abdulaziz M</creatorcontrib><creatorcontrib>Abdulrahman, Albasseet</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Curēus (Palo Alto, CA)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Abubaker, Saleh A</au><au>Alonazy, Abdulaziz M</au><au>Abdulrahman, Albasseet</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Alpha-Lipoic Acid in the Treatment of Diabetic Neuropathy: A Systematic Review</atitle><jtitle>Curēus (Palo Alto, CA)</jtitle><addtitle>Cureus</addtitle><date>2022-06-08</date><risdate>2022</risdate><volume>14</volume><issue>6</issue><spage>e25750</spage><pages>e25750-</pages><issn>2168-8184</issn><eissn>2168-8184</eissn><abstract>Diabetic neuropathy is a clinical condition that can have a significant impact on quality of life, presenting as numbness, tingling, and burning in the extremities. 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| subjects | Acids Antidepressants Bias Clinical trials Data collection Diabetes Diabetic neuropathy Drug dosages Endocrinology/Diabetes/Metabolism Evidence-based medicine Family/General Practice Intervention Pain Pain Management Peripheral neuropathy Systematic review |
| title | Effect of Alpha-Lipoic Acid in the Treatment of Diabetic Neuropathy: A Systematic Review |
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