Ampicillin dosing in premature infants for early-onset sepsis: exposure-driven efficacy, safety, and stewardship

Objective Define optimal ampicillin dosing for empiric early-onset sepsis (EOS) therapy in preterm neonates. Study design We simulated ampicillin concentrations in newborns (birthweight 90% maintained concentrations >MIC beyond 48 h. With the 2-dose regimen, newborns maintained the mean concentra...

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Veröffentlicht in:	Journal of perinatology 2022-07, Vol.42 (7), p.959-964
Hauptverfasser:	Le, Jennifer, Greenberg, Rachel G., Yoo, YoungJun, Clark, Reese H., Benjamin, Daniel K., Zimmerman, Kanecia O., Cohen-Wolkowiez, Michael, Wade, Kelly C.
Format:	Artikel
Sprache:	eng
Schlagworte:	692/700/1720 692/700/565/1436/152 Age Ampicillin Ampicillin - therapeutic use Anti-Bacterial Agents - therapeutic use Antibiotics Birth weight Clinical medicine Dosage Drug dosages Exposure Gestation Gestational age Humans Infant Infant, Newborn Infant, Premature Infant, Premature, Diseases - drug therapy Infant, Very Low Birth Weight Infants Medicine Medicine & Public Health Minimum inhibitory concentration Neonates Neurotoxicity Newborn babies Pathogens Pediatric Surgery Pediatrics Penicillin Pharmacokinetics Premature babies Premature birth Sepsis Sepsis - drug therapy Simulation Toxicity
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