The Outcome of Immediate Administration of Dexamethasone in Children With Croup (Laryngotracheobronchitis) in King Abdullah Specialized Children’s Hospital
BackgroundCroup is an inflammatory disease that affects the upper respiratory tract involving the upper airways of the lungs (bronchial tubes), vocal cords (larynx), and windpipe (trachea). In Canada, it is considered one of the major causes of respiratory diseases in the first 10 years of life. A w...
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| description | BackgroundCroup is an inflammatory disease that affects the upper respiratory tract involving the upper airways of the lungs (bronchial tubes), vocal cords (larynx), and windpipe (trachea). In Canada, it is considered one of the major causes of respiratory diseases in the first 10 years of life. A wide range of viruses like common cold and flu (influenza) infections can cause croup (laryngotracheobronchitis). Dexamethasone has been commonly used to treat croup even though it lacks evidence on patients' recovery. The study aimed to compare the effect of the immediate or late dexamethasone administration on patient recovery and identify predictors for relapse among children with croup.MethodsA retrospective cross-sectional study was conducted using the electronic medical record (Best Care) of all croup patients between 2014 and 2018 in King Abdullah Specialized Children's Hospital (KASCH), in Riyadh, Saudi Arabia. Out of the 329, only 186 patients matched our inclusion criteria. Statistical analysis was conducted with the SPSS V.22 software package (IBM Corp., Armonk, NY). The main outcome variable was early recovery or relapse. The chi-square test and logistic regression were used to assess the relationship between the independent variables with recovery or relapse among croup patients. A p-value of |
| doi_str_mv | 10.7759/cureus.25726 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9262250</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2688089734</sourcerecordid><originalsourceid>FETCH-LOGICAL-c319t-e3cad9c47717a88cf916c4322366c64f2d64ef9c0ebe462002d0e67c81e8e2f83</originalsourceid><addsrcrecordid>eNpdUctqFEEULcRgQszODyhwE8GJ9eiuqt4Iw_hIcCALIy6Lmurb0xW6q9p6hMSVv-HCn_NL7HFCiK7uhfPgHA5CLyg5k7Ju3tgSoaQzVksmnqAjRoVaKKqqp4_-Q3SS0jUhhBLJiCTP0CGvFWV13RyhX1c94MuSbRgBhw5fjCO0zmTAy3Z03qUcTXbB77B3cGtGyL1JwQN2Hq96N7QRPP7qco9XMZQJn65NvPPbMOtsD2ETg7e9yy692ik-Ob_Fy01bhsH0-PME1pnBfYf2wev3j58Jn4c0uWyG5-igM0OCk_t7jL58eH-1Ol-sLz9erJbrheW0yQvg1rSNraSk0ihlu4YKW3HGuBBWVB1rRQVdYwlsoBKMENYSENIqCgpYp_gxerv3ncpm7m_Bz_EHPUU3zm10ME7_i3jX62240Q0TjNVkNji9N4jhW4GU9eiShbmlh1CSZkIpohrJq5n68j_qdSjRz_VmViOk4rTeJXq9Z9kYUorQPYShRO-m1_vp9d_p-R-huKWx</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2696783158</pqid></control><display><type>article</type><title>The Outcome of Immediate Administration of Dexamethasone in Children With Croup (Laryngotracheobronchitis) in King Abdullah Specialized Children’s Hospital</title><source>PubMed Central Open Access</source><source>PubMed Central</source><creator>Alqahtani, Abdulaziz A ; Masud, Nazish ; Algazlan, Mohammad S ; Alqarni, Saleh S ; Almutairi, Khalifah N ; Bahumiad, Abdullah A ; AlQueflie, Sulaiman A</creator><creatorcontrib>Alqahtani, Abdulaziz A ; Masud, Nazish ; Algazlan, Mohammad S ; Alqarni, Saleh S ; Almutairi, Khalifah N ; Bahumiad, Abdullah A ; AlQueflie, Sulaiman A</creatorcontrib><description>BackgroundCroup is an inflammatory disease that affects the upper respiratory tract involving the upper airways of the lungs (bronchial tubes), vocal cords (larynx), and windpipe (trachea). In Canada, it is considered one of the major causes of respiratory diseases in the first 10 years of life. A wide range of viruses like common cold and flu (influenza) infections can cause croup (laryngotracheobronchitis). Dexamethasone has been commonly used to treat croup even though it lacks evidence on patients' recovery. The study aimed to compare the effect of the immediate or late dexamethasone administration on patient recovery and identify predictors for relapse among children with croup.MethodsA retrospective cross-sectional study was conducted using the electronic medical record (Best Care) of all croup patients between 2014 and 2018 in King Abdullah Specialized Children's Hospital (KASCH), in Riyadh, Saudi Arabia. Out of the 329, only 186 patients matched our inclusion criteria. Statistical analysis was conducted with the SPSS V.22 software package (IBM Corp., Armonk, NY). The main outcome variable was early recovery or relapse. The chi-square test and logistic regression were used to assess the relationship between the independent variables with recovery or relapse among croup patients. A p-value of <0.05 was used to determine the significance of the test.ResultsFifty-three recovered out of the 186 patients. Moreover, 50 of the recovered patients were treated in the ER. In addition, out of the 53 patients who recovered, 40 patients were treated as inpatients (IPs). Those who were given dexamethasone immediately for both recovery and relapsed groups were 29% and 71%, respectively while those who were given dexamethasone late were 34% for the recovery group. On the other hand, 119 patients relapsed. Out of those patients who relapsed, 111 were treated in the ER. Moreover, out of relapsed patients, 79 patients were treated as IPs. Furthermore, out of 186 patients, 86 had chronic illnesses. Twenty-four percent (24%) of those with chronic illnesses recovered, and 76% relapsed (P-value=0.04). Also, there was a significantly higher trend of administration of dexamethasone immediately in the ER in 69% of children with a p-value <0.001.ConclusionIn conclusion, the difference between the early and late administration of dexamethasone in both recovery and relapse is not significant. Also, the presence of chronic illnesses affects relapses more significantly.</description><identifier>ISSN: 2168-8184</identifier><identifier>EISSN: 2168-8184</identifier><identifier>DOI: 10.7759/cureus.25726</identifier><identifier>PMID: 35812559</identifier><language>eng</language><publisher>Palo Alto: Cureus Inc</publisher><subject>Bacterial infections ; Cartilage ; Children & youth ; Data collection ; Disease ; Drug dosages ; Edema ; Electronic health records ; Emergency Medicine ; Hospitals ; Infections ; Influenza ; Medical records ; Pathogens ; Patients ; Pediatrics ; Steroids ; Therapeutics</subject><ispartof>Curēus (Palo Alto, CA), 2022-06, Vol.14 (6), p.e25726-e25726</ispartof><rights>Copyright © 2022, Alqahtani et al. This work is published under https://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Copyright © 2022, Alqahtani et al. 2022 Alqahtani et al.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c319t-e3cad9c47717a88cf916c4322366c64f2d64ef9c0ebe462002d0e67c81e8e2f83</citedby><cites>FETCH-LOGICAL-c319t-e3cad9c47717a88cf916c4322366c64f2d64ef9c0ebe462002d0e67c81e8e2f83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9262250/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9262250/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53769,53771</link.rule.ids></links><search><creatorcontrib>Alqahtani, Abdulaziz A</creatorcontrib><creatorcontrib>Masud, Nazish</creatorcontrib><creatorcontrib>Algazlan, Mohammad S</creatorcontrib><creatorcontrib>Alqarni, Saleh S</creatorcontrib><creatorcontrib>Almutairi, Khalifah N</creatorcontrib><creatorcontrib>Bahumiad, Abdullah A</creatorcontrib><creatorcontrib>AlQueflie, Sulaiman A</creatorcontrib><title>The Outcome of Immediate Administration of Dexamethasone in Children With Croup (Laryngotracheobronchitis) in King Abdullah Specialized Children’s Hospital</title><title>Curēus (Palo Alto, CA)</title><description>BackgroundCroup is an inflammatory disease that affects the upper respiratory tract involving the upper airways of the lungs (bronchial tubes), vocal cords (larynx), and windpipe (trachea). In Canada, it is considered one of the major causes of respiratory diseases in the first 10 years of life. A wide range of viruses like common cold and flu (influenza) infections can cause croup (laryngotracheobronchitis). Dexamethasone has been commonly used to treat croup even though it lacks evidence on patients' recovery. The study aimed to compare the effect of the immediate or late dexamethasone administration on patient recovery and identify predictors for relapse among children with croup.MethodsA retrospective cross-sectional study was conducted using the electronic medical record (Best Care) of all croup patients between 2014 and 2018 in King Abdullah Specialized Children's Hospital (KASCH), in Riyadh, Saudi Arabia. Out of the 329, only 186 patients matched our inclusion criteria. Statistical analysis was conducted with the SPSS V.22 software package (IBM Corp., Armonk, NY). The main outcome variable was early recovery or relapse. The chi-square test and logistic regression were used to assess the relationship between the independent variables with recovery or relapse among croup patients. A p-value of <0.05 was used to determine the significance of the test.ResultsFifty-three recovered out of the 186 patients. Moreover, 50 of the recovered patients were treated in the ER. In addition, out of the 53 patients who recovered, 40 patients were treated as inpatients (IPs). Those who were given dexamethasone immediately for both recovery and relapsed groups were 29% and 71%, respectively while those who were given dexamethasone late were 34% for the recovery group. On the other hand, 119 patients relapsed. Out of those patients who relapsed, 111 were treated in the ER. Moreover, out of relapsed patients, 79 patients were treated as IPs. Furthermore, out of 186 patients, 86 had chronic illnesses. Twenty-four percent (24%) of those with chronic illnesses recovered, and 76% relapsed (P-value=0.04). Also, there was a significantly higher trend of administration of dexamethasone immediately in the ER in 69% of children with a p-value <0.001.ConclusionIn conclusion, the difference between the early and late administration of dexamethasone in both recovery and relapse is not significant. Also, the presence of chronic illnesses affects relapses more significantly.</description><subject>Bacterial infections</subject><subject>Cartilage</subject><subject>Children & youth</subject><subject>Data collection</subject><subject>Disease</subject><subject>Drug dosages</subject><subject>Edema</subject><subject>Electronic health records</subject><subject>Emergency Medicine</subject><subject>Hospitals</subject><subject>Infections</subject><subject>Influenza</subject><subject>Medical records</subject><subject>Pathogens</subject><subject>Patients</subject><subject>Pediatrics</subject><subject>Steroids</subject><subject>Therapeutics</subject><issn>2168-8184</issn><issn>2168-8184</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNpdUctqFEEULcRgQszODyhwE8GJ9eiuqt4Iw_hIcCALIy6Lmurb0xW6q9p6hMSVv-HCn_NL7HFCiK7uhfPgHA5CLyg5k7Ju3tgSoaQzVksmnqAjRoVaKKqqp4_-Q3SS0jUhhBLJiCTP0CGvFWV13RyhX1c94MuSbRgBhw5fjCO0zmTAy3Z03qUcTXbB77B3cGtGyL1JwQN2Hq96N7QRPP7qco9XMZQJn65NvPPbMOtsD2ETg7e9yy692ik-Ob_Fy01bhsH0-PME1pnBfYf2wev3j58Jn4c0uWyG5-igM0OCk_t7jL58eH-1Ol-sLz9erJbrheW0yQvg1rSNraSk0ihlu4YKW3HGuBBWVB1rRQVdYwlsoBKMENYSENIqCgpYp_gxerv3ncpm7m_Bz_EHPUU3zm10ME7_i3jX62240Q0TjNVkNji9N4jhW4GU9eiShbmlh1CSZkIpohrJq5n68j_qdSjRz_VmViOk4rTeJXq9Z9kYUorQPYShRO-m1_vp9d_p-R-huKWx</recordid><startdate>20220607</startdate><enddate>20220607</enddate><creator>Alqahtani, Abdulaziz A</creator><creator>Masud, Nazish</creator><creator>Algazlan, Mohammad S</creator><creator>Alqarni, Saleh S</creator><creator>Almutairi, Khalifah N</creator><creator>Bahumiad, Abdullah A</creator><creator>AlQueflie, Sulaiman A</creator><general>Cureus Inc</general><general>Cureus</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20220607</creationdate><title>The Outcome of Immediate Administration of Dexamethasone in Children With Croup (Laryngotracheobronchitis) in King Abdullah Specialized Children’s Hospital</title><author>Alqahtani, Abdulaziz A ; Masud, Nazish ; Algazlan, Mohammad S ; Alqarni, Saleh S ; Almutairi, Khalifah N ; Bahumiad, Abdullah A ; AlQueflie, Sulaiman A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c319t-e3cad9c47717a88cf916c4322366c64f2d64ef9c0ebe462002d0e67c81e8e2f83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Bacterial infections</topic><topic>Cartilage</topic><topic>Children & youth</topic><topic>Data collection</topic><topic>Disease</topic><topic>Drug dosages</topic><topic>Edema</topic><topic>Electronic health records</topic><topic>Emergency Medicine</topic><topic>Hospitals</topic><topic>Infections</topic><topic>Influenza</topic><topic>Medical records</topic><topic>Pathogens</topic><topic>Patients</topic><topic>Pediatrics</topic><topic>Steroids</topic><topic>Therapeutics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Alqahtani, Abdulaziz A</creatorcontrib><creatorcontrib>Masud, Nazish</creatorcontrib><creatorcontrib>Algazlan, Mohammad S</creatorcontrib><creatorcontrib>Alqarni, Saleh S</creatorcontrib><creatorcontrib>Almutairi, Khalifah N</creatorcontrib><creatorcontrib>Bahumiad, Abdullah A</creatorcontrib><creatorcontrib>AlQueflie, Sulaiman A</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Curēus (Palo Alto, CA)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Alqahtani, Abdulaziz A</au><au>Masud, Nazish</au><au>Algazlan, Mohammad S</au><au>Alqarni, Saleh S</au><au>Almutairi, Khalifah N</au><au>Bahumiad, Abdullah A</au><au>AlQueflie, Sulaiman A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Outcome of Immediate Administration of Dexamethasone in Children With Croup (Laryngotracheobronchitis) in King Abdullah Specialized Children’s Hospital</atitle><jtitle>Curēus (Palo Alto, CA)</jtitle><date>2022-06-07</date><risdate>2022</risdate><volume>14</volume><issue>6</issue><spage>e25726</spage><epage>e25726</epage><pages>e25726-e25726</pages><issn>2168-8184</issn><eissn>2168-8184</eissn><abstract>BackgroundCroup is an inflammatory disease that affects the upper respiratory tract involving the upper airways of the lungs (bronchial tubes), vocal cords (larynx), and windpipe (trachea). In Canada, it is considered one of the major causes of respiratory diseases in the first 10 years of life. A wide range of viruses like common cold and flu (influenza) infections can cause croup (laryngotracheobronchitis). Dexamethasone has been commonly used to treat croup even though it lacks evidence on patients' recovery. The study aimed to compare the effect of the immediate or late dexamethasone administration on patient recovery and identify predictors for relapse among children with croup.MethodsA retrospective cross-sectional study was conducted using the electronic medical record (Best Care) of all croup patients between 2014 and 2018 in King Abdullah Specialized Children's Hospital (KASCH), in Riyadh, Saudi Arabia. Out of the 329, only 186 patients matched our inclusion criteria. Statistical analysis was conducted with the SPSS V.22 software package (IBM Corp., Armonk, NY). The main outcome variable was early recovery or relapse. The chi-square test and logistic regression were used to assess the relationship between the independent variables with recovery or relapse among croup patients. A p-value of <0.05 was used to determine the significance of the test.ResultsFifty-three recovered out of the 186 patients. Moreover, 50 of the recovered patients were treated in the ER. In addition, out of the 53 patients who recovered, 40 patients were treated as inpatients (IPs). Those who were given dexamethasone immediately for both recovery and relapsed groups were 29% and 71%, respectively while those who were given dexamethasone late were 34% for the recovery group. On the other hand, 119 patients relapsed. Out of those patients who relapsed, 111 were treated in the ER. Moreover, out of relapsed patients, 79 patients were treated as IPs. Furthermore, out of 186 patients, 86 had chronic illnesses. Twenty-four percent (24%) of those with chronic illnesses recovered, and 76% relapsed (P-value=0.04). Also, there was a significantly higher trend of administration of dexamethasone immediately in the ER in 69% of children with a p-value <0.001.ConclusionIn conclusion, the difference between the early and late administration of dexamethasone in both recovery and relapse is not significant. Also, the presence of chronic illnesses affects relapses more significantly.</abstract><cop>Palo Alto</cop><pub>Cureus Inc</pub><pmid>35812559</pmid><doi>10.7759/cureus.25726</doi><oa>free_for_read</oa></addata></record> |
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| source | PubMed Central Open Access; PubMed Central |
| subjects | Bacterial infections Cartilage Children & youth Data collection Disease Drug dosages Edema Electronic health records Emergency Medicine Hospitals Infections Influenza Medical records Pathogens Patients Pediatrics Steroids Therapeutics |
| title | The Outcome of Immediate Administration of Dexamethasone in Children With Croup (Laryngotracheobronchitis) in King Abdullah Specialized Children’s Hospital |
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