Glymphatic System in Ocular Diseases: Evaluation of MRI Findings
There is growing evidence of leakage of gadolinium in an impaired blood-retina barrier. We investigated gadolinium enhancement in different eye compartments and correlated the enhancement with specific ophthalmologic diseases. In a prospective clinical study (ClinicalTrials.gov Identifier: NCT050352...
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Veröffentlicht in: | American journal of neuroradiology : AJNR 2022-07, Vol.43 (7), p.1012-1017 |
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creator | Manava, P Eckrich, C Luciani, F Schmidbauer, J Lell, M M Detmar, K |
description | There is growing evidence of leakage of gadolinium in an impaired blood-retina barrier. We investigated gadolinium enhancement in different eye compartments and correlated the enhancement with specific ophthalmologic diseases.
In a prospective clinical study (ClinicalTrials.gov Identifier: NCT05035251), 95 patients (63 with and 32 without ophthalmologic disease) were examined before and after gadolinium administration (20 and 120 minutes) with heavily T2-weighted FLAIR. The cohort was divided according to the location of pathology into anterior and posterior eye compartment groups. Relative signal intensity increase in the anterior eye chamber, vitreous body with retina, optic nerve sheath, and the Meckel cave was analyzed and correlated with the final clinical diagnosis.
In patients with a disorder in the anterior eye compartment, significant signal intensity increases were found in the central anterior eye chamber (
20 minutes = .000,
120 minutes = .000), lateral anterior eye chamber (
20 minutes = .001,
120 minutes = .005), and vitreous body with retina (
20 minutes = .02) compared with the control group. Patients with pathologies in the posterior eye compartment showed higher signal intensity levels in the central anterior eye compartment (
20 minutes = .041) and vitreous body with retina (
120 minutes = .006).
Increased gadolinium enhancement was found in the central and lateral anterior eye compartments and the vitreous body with retina in patients with anterior eye compartment disorders 20 and 120 minutes after contrast application, suggesting impairment of the blood-aqueous barrier. In patients with a disorder in the posterior eye compartment, pathologic enhancement indicated disruption of the blood-retinal barrier that allows gadolinium to diffuse into the vitreous body with retina from posterior to anterior, opposite to the known physiologic glymphatic pathway. |
doi_str_mv | 10.3174/ajnr.a7552 |
format | Article |
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In a prospective clinical study (ClinicalTrials.gov Identifier: NCT05035251), 95 patients (63 with and 32 without ophthalmologic disease) were examined before and after gadolinium administration (20 and 120 minutes) with heavily T2-weighted FLAIR. The cohort was divided according to the location of pathology into anterior and posterior eye compartment groups. Relative signal intensity increase in the anterior eye chamber, vitreous body with retina, optic nerve sheath, and the Meckel cave was analyzed and correlated with the final clinical diagnosis.
In patients with a disorder in the anterior eye compartment, significant signal intensity increases were found in the central anterior eye chamber (
20 minutes = .000,
120 minutes = .000), lateral anterior eye chamber (
20 minutes = .001,
120 minutes = .005), and vitreous body with retina (
20 minutes = .02) compared with the control group. Patients with pathologies in the posterior eye compartment showed higher signal intensity levels in the central anterior eye compartment (
20 minutes = .041) and vitreous body with retina (
120 minutes = .006).
Increased gadolinium enhancement was found in the central and lateral anterior eye compartments and the vitreous body with retina in patients with anterior eye compartment disorders 20 and 120 minutes after contrast application, suggesting impairment of the blood-aqueous barrier. In patients with a disorder in the posterior eye compartment, pathologic enhancement indicated disruption of the blood-retinal barrier that allows gadolinium to diffuse into the vitreous body with retina from posterior to anterior, opposite to the known physiologic glymphatic pathway.</description><identifier>ISSN: 0195-6108</identifier><identifier>EISSN: 1936-959X</identifier><identifier>DOI: 10.3174/ajnr.a7552</identifier><identifier>PMID: 35772805</identifier><language>eng</language><publisher>United States: American Society of Neuroradiology</publisher><subject>Contrast Media - metabolism ; Editor's Choice ; Gadolinium - metabolism ; Glymphatic System ; Head & Neck ; Humans ; Magnetic Resonance Imaging ; Prospective Studies ; Vitreous Body - diagnostic imaging ; Vitreous Body - metabolism</subject><ispartof>American journal of neuroradiology : AJNR, 2022-07, Vol.43 (7), p.1012-1017</ispartof><rights>2022 by American Journal of Neuroradiology.</rights><rights>2022 by American Journal of Neuroradiology 2022 American Journal of Neuroradiology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c444t-daef6180edced756c61bd2b2c739125c9d99da50cc755da45e8561113a760b2a3</citedby><cites>FETCH-LOGICAL-c444t-daef6180edced756c61bd2b2c739125c9d99da50cc755da45e8561113a760b2a3</cites><orcidid>0000-0003-1765-7183 ; 0000-0002-1766-4650</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9262072/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9262072/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35772805$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Manava, P</creatorcontrib><creatorcontrib>Eckrich, C</creatorcontrib><creatorcontrib>Luciani, F</creatorcontrib><creatorcontrib>Schmidbauer, J</creatorcontrib><creatorcontrib>Lell, M M</creatorcontrib><creatorcontrib>Detmar, K</creatorcontrib><title>Glymphatic System in Ocular Diseases: Evaluation of MRI Findings</title><title>American journal of neuroradiology : AJNR</title><addtitle>AJNR Am J Neuroradiol</addtitle><description>There is growing evidence of leakage of gadolinium in an impaired blood-retina barrier. We investigated gadolinium enhancement in different eye compartments and correlated the enhancement with specific ophthalmologic diseases.
In a prospective clinical study (ClinicalTrials.gov Identifier: NCT05035251), 95 patients (63 with and 32 without ophthalmologic disease) were examined before and after gadolinium administration (20 and 120 minutes) with heavily T2-weighted FLAIR. The cohort was divided according to the location of pathology into anterior and posterior eye compartment groups. Relative signal intensity increase in the anterior eye chamber, vitreous body with retina, optic nerve sheath, and the Meckel cave was analyzed and correlated with the final clinical diagnosis.
In patients with a disorder in the anterior eye compartment, significant signal intensity increases were found in the central anterior eye chamber (
20 minutes = .000,
120 minutes = .000), lateral anterior eye chamber (
20 minutes = .001,
120 minutes = .005), and vitreous body with retina (
20 minutes = .02) compared with the control group. Patients with pathologies in the posterior eye compartment showed higher signal intensity levels in the central anterior eye compartment (
20 minutes = .041) and vitreous body with retina (
120 minutes = .006).
Increased gadolinium enhancement was found in the central and lateral anterior eye compartments and the vitreous body with retina in patients with anterior eye compartment disorders 20 and 120 minutes after contrast application, suggesting impairment of the blood-aqueous barrier. In patients with a disorder in the posterior eye compartment, pathologic enhancement indicated disruption of the blood-retinal barrier that allows gadolinium to diffuse into the vitreous body with retina from posterior to anterior, opposite to the known physiologic glymphatic pathway.</description><subject>Contrast Media - metabolism</subject><subject>Editor's Choice</subject><subject>Gadolinium - metabolism</subject><subject>Glymphatic System</subject><subject>Head & Neck</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Prospective Studies</subject><subject>Vitreous Body - diagnostic imaging</subject><subject>Vitreous Body - metabolism</subject><issn>0195-6108</issn><issn>1936-959X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkF1LwzAUQIMobk5f_AHSRxE6k7RJGh_EMbc5mAz8AN9CmmRbRpvOph3s39uyOfQpD_dw7s0B4BrBfoRYfC_XruxLRgg-AV3EIxpywr9OQRciTkKKYNIBF96vIYSEM3wOOhFhDCeQdMHTJNvlm5WsrAred74yeWBdMFd1Jsvg2XojvfEPwWgrs7qBChcUi-D1bRqMrdPWLf0lOFvIzJurw9sDn-PRx_AlnM0n0-FgFqo4jqtQS7OgKIFGK6MZoYqiVOMUKxZxhInimnMtCVSq-YeWMTEJoQihSDIKUyyjHnjcezd1mrcWV5UyE5vS5rLciUJa8X_i7Eosi63gmGLIcCO4PQjK4rs2vhK59cpkmXSmqL3ANIkRxJDDBr3bo6osvC_N4rgGQdEmF21yMWiTN_DN38OO6G_j6Af4en2s</recordid><startdate>20220701</startdate><enddate>20220701</enddate><creator>Manava, P</creator><creator>Eckrich, C</creator><creator>Luciani, F</creator><creator>Schmidbauer, J</creator><creator>Lell, M M</creator><creator>Detmar, K</creator><general>American Society of Neuroradiology</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-1765-7183</orcidid><orcidid>https://orcid.org/0000-0002-1766-4650</orcidid></search><sort><creationdate>20220701</creationdate><title>Glymphatic System in Ocular Diseases: Evaluation of MRI Findings</title><author>Manava, P ; Eckrich, C ; Luciani, F ; Schmidbauer, J ; Lell, M M ; Detmar, K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c444t-daef6180edced756c61bd2b2c739125c9d99da50cc755da45e8561113a760b2a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Contrast Media - metabolism</topic><topic>Editor's Choice</topic><topic>Gadolinium - metabolism</topic><topic>Glymphatic System</topic><topic>Head & Neck</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging</topic><topic>Prospective Studies</topic><topic>Vitreous Body - diagnostic imaging</topic><topic>Vitreous Body - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Manava, P</creatorcontrib><creatorcontrib>Eckrich, C</creatorcontrib><creatorcontrib>Luciani, F</creatorcontrib><creatorcontrib>Schmidbauer, J</creatorcontrib><creatorcontrib>Lell, M M</creatorcontrib><creatorcontrib>Detmar, K</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>American journal of neuroradiology : AJNR</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Manava, P</au><au>Eckrich, C</au><au>Luciani, F</au><au>Schmidbauer, J</au><au>Lell, M M</au><au>Detmar, K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Glymphatic System in Ocular Diseases: Evaluation of MRI Findings</atitle><jtitle>American journal of neuroradiology : AJNR</jtitle><addtitle>AJNR Am J Neuroradiol</addtitle><date>2022-07-01</date><risdate>2022</risdate><volume>43</volume><issue>7</issue><spage>1012</spage><epage>1017</epage><pages>1012-1017</pages><issn>0195-6108</issn><eissn>1936-959X</eissn><abstract>There is growing evidence of leakage of gadolinium in an impaired blood-retina barrier. We investigated gadolinium enhancement in different eye compartments and correlated the enhancement with specific ophthalmologic diseases.
In a prospective clinical study (ClinicalTrials.gov Identifier: NCT05035251), 95 patients (63 with and 32 without ophthalmologic disease) were examined before and after gadolinium administration (20 and 120 minutes) with heavily T2-weighted FLAIR. The cohort was divided according to the location of pathology into anterior and posterior eye compartment groups. Relative signal intensity increase in the anterior eye chamber, vitreous body with retina, optic nerve sheath, and the Meckel cave was analyzed and correlated with the final clinical diagnosis.
In patients with a disorder in the anterior eye compartment, significant signal intensity increases were found in the central anterior eye chamber (
20 minutes = .000,
120 minutes = .000), lateral anterior eye chamber (
20 minutes = .001,
120 minutes = .005), and vitreous body with retina (
20 minutes = .02) compared with the control group. Patients with pathologies in the posterior eye compartment showed higher signal intensity levels in the central anterior eye compartment (
20 minutes = .041) and vitreous body with retina (
120 minutes = .006).
Increased gadolinium enhancement was found in the central and lateral anterior eye compartments and the vitreous body with retina in patients with anterior eye compartment disorders 20 and 120 minutes after contrast application, suggesting impairment of the blood-aqueous barrier. In patients with a disorder in the posterior eye compartment, pathologic enhancement indicated disruption of the blood-retinal barrier that allows gadolinium to diffuse into the vitreous body with retina from posterior to anterior, opposite to the known physiologic glymphatic pathway.</abstract><cop>United States</cop><pub>American Society of Neuroradiology</pub><pmid>35772805</pmid><doi>10.3174/ajnr.a7552</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0003-1765-7183</orcidid><orcidid>https://orcid.org/0000-0002-1766-4650</orcidid><oa>free_for_read</oa></addata></record> |
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source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central |
subjects | Contrast Media - metabolism Editor's Choice Gadolinium - metabolism Glymphatic System Head & Neck Humans Magnetic Resonance Imaging Prospective Studies Vitreous Body - diagnostic imaging Vitreous Body - metabolism |
title | Glymphatic System in Ocular Diseases: Evaluation of MRI Findings |
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