Skin Injury Activates a Rapid TRPV1-Dependent Antiviral Protein Response

The skin serves as the interface between the body and the environment and plays a fundamental role in innate antimicrobial host immunity. Antiviral proteins (AVPs) are part of the innate host defense system and provide protection against viral pathogens. How breach of the skin barrier influences inn...

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Veröffentlicht in:	Journal of investigative dermatology 2022-08, Vol.142 (8), p.2249-2259.e9
Hauptverfasser:	Lei, Vivian, Handfield, Chelsea, Kwock, Jeffery T., Kirchner, Stephen J., Lee, Min Jin, Coates, Margaret, Wang, Kaiyuan, Han, Qingjian, Wang, Zilong, Powers, Jennifer G., Wolfe, Sarah, Corcoran, David L., Fanelli, Brian, Dadlani, Manoj, Ji, Ru-Rong, Zhang, Jennifer Y., MacLeod, Amanda S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antiviral Restriction Factors - immunology Herpes Simplex - immunology Humans Immunity, Innate Interleukin-27 - immunology Mice Nociceptors - metabolism Skin - injuries TRPV Cation Channels - genetics TRPV Cation Channels - metabolism
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