Role of ErbB1 in the Underlying Mechanism of Lapatinib-Induced Diarrhoea: A Review

Lapatinib, an orally administered small-molecule tyrosine kinase inhibitor (SM-TKI), is an effective treatment for ErbB2-positive breast cancer. However, its efficacy as one of the targeted cancer therapies has been hampered by several adverse effects, especially gastrointestinal toxicity, commonly...

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Veröffentlicht in:	BioMed research international 2022, Vol.2022 (1)
Hauptverfasser:	Raja Sharin, Raja Nur Firzanah Syaza, Khan, Jesmine, Ibahim, Mohamad Johari, Muhamad, Mudiana, Bowen, Joanne, Wan Mohamad Zain, Wan Nor I’zzah
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Binding sites Breast cancer Cancer therapies Causes of Chemotherapy Cytokines Dehydration Development and progression Diarrhea Digestive system Enzyme inhibitors Epidermal growth factor Epithelium ErbB-1 protein ErbB-2 protein Gastrointestinal tract Genetic aspects Growth factors Health aspects Homeostasis Inflammation Inflammatory bowel disease Inhibitor drugs Kinases Ligands Malabsorption Oral administration Permeability Phosphotransferases Protein-tyrosine kinase Proteins Quality of life Review Targeted cancer therapy Toxicity Tumor necrosis factor-TNF Tyrosine Wound healing
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