Histopathology of acute colchicine intoxication: novel findings and their association with clinical manifestations
A 32-year-old woman attempted suicide by ingesting Gloriosa bulbs and died approximately 2 days later. Toxicological examination revealed a potentially fatal blood concentration of colchicine (0.096 mg/L). In addition to the increased mitotic figures in the gastrointestinal mucosa, a unique finding...
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| Veröffentlicht in: | Journal of Toxicologic Pathology 2022, Vol.35(3), pp.255-262 |
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| creator | Ichimata, Shojiro Hata, Yukiko Hirota, Kojiro Nishida, Naoki |
| description | A 32-year-old woman attempted suicide by ingesting Gloriosa bulbs and died approximately 2 days later. Toxicological examination revealed a potentially fatal blood concentration of colchicine (0.096 mg/L). In addition to the increased mitotic figures in the gastrointestinal mucosa, a unique finding for acute colchicine intoxication, pathological examination showed microvesicular lipid droplets in the liver, kidney, heart, and conduction system. Furthermore, central chromatolysis of neurons was observed in the pontine nucleus, medial accessory olivary nucleus, nucleus of the solitary tract, and nucleus ambiguus. Grumose degeneration of the cerebellar dentate nucleus was also evident. These pathological findings may help identify colchicine intoxication, even in the absence of evidence suggesting ingestion during autopsy. Moreover, pathological changes in the heart and central nervous system may be associated with the development of serious complications of acute colchicine intoxication. |
| doi_str_mv | 10.1293/tox.2022-0007 |
| format | Article |
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Toxicological examination revealed a potentially fatal blood concentration of colchicine (0.096 mg/L). In addition to the increased mitotic figures in the gastrointestinal mucosa, a unique finding for acute colchicine intoxication, pathological examination showed microvesicular lipid droplets in the liver, kidney, heart, and conduction system. Furthermore, central chromatolysis of neurons was observed in the pontine nucleus, medial accessory olivary nucleus, nucleus of the solitary tract, and nucleus ambiguus. Grumose degeneration of the cerebellar dentate nucleus was also evident. These pathological findings may help identify colchicine intoxication, even in the absence of evidence suggesting ingestion during autopsy. 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Toxicological examination revealed a potentially fatal blood concentration of colchicine (0.096 mg/L). In addition to the increased mitotic figures in the gastrointestinal mucosa, a unique finding for acute colchicine intoxication, pathological examination showed microvesicular lipid droplets in the liver, kidney, heart, and conduction system. Furthermore, central chromatolysis of neurons was observed in the pontine nucleus, medial accessory olivary nucleus, nucleus of the solitary tract, and nucleus ambiguus. Grumose degeneration of the cerebellar dentate nucleus was also evident. These pathological findings may help identify colchicine intoxication, even in the absence of evidence suggesting ingestion during autopsy. Moreover, pathological changes in the heart and central nervous system may be associated with the development of serious complications of acute colchicine intoxication.</description><subject>Autopsies</subject><subject>Autopsy</subject><subject>Blood levels</subject><subject>Case Report</subject><subject>Central nervous system</subject><subject>Cerebellum</subject><subject>Colchicine</subject><subject>Degeneration</subject><subject>Dentate nucleus</subject><subject>Fatalities</subject><subject>heart</subject><subject>Histopathology</subject><subject>Ingestion</subject><subject>Intoxication</subject><subject>lipid droplets</subject><subject>Lipids</subject><subject>mitochondria</subject><subject>Nucleus ambiguus</subject><subject>Reye’s syndrome</subject><subject>Solitary tract nucleus</subject><subject>Suicide</subject><issn>0914-9198</issn><issn>1881-915X</issn><issn>1347-7404</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp9kc1rGzEQxUVJaNykx94FPW-qj9WulEMhmKYpBHppIDcxlrRembXkSHLS_PeR7WDIJRdJ8H4z8zQPoW-UXFKm-I8S_18ywlhDCOk_oRmVkjaKiocTNCOKtvWt5Bn6kvOKENYTwT-jMy4kZ4rQGUq3Ppe4gTLGKS5fcBwwmG1x2MTJjN744LAPdYg3UHwMVzjEJzfhwQfrwzJjCBaX0fmEIedo_J7Cz76M2Ew-1LIJryH4weWy1_IFOh1gyu7r232O7m9-_ZvfNnd_f_-ZX981pu360nCQAKKTlpNWsW6xYMZJRYyiZJBCMrCtBSJEy9Vgu_p52XbWQs_lgkjZU36Ofh76braLtbPGhZJg0pvk15BedASv3yvBj3oZn7RiQijV1Qbf3xqk-Lit_vUqblOonjXrRSuk7AT5kOokp5L3nFeqOVAmxZyTG44-KNG7IHXdsd4FqXdBVn5-4Fd1bUt3pCEVbya3p7nQfHccq46qGSFpF_grUYSp-Q</recordid><startdate>20220101</startdate><enddate>20220101</enddate><creator>Ichimata, Shojiro</creator><creator>Hata, Yukiko</creator><creator>Hirota, Kojiro</creator><creator>Nishida, Naoki</creator><general>JAPANESE SOCIETY OF TOXICOLOGIC PATHOLOGY</general><general>Japan Science and Technology Agency</general><general>Japanese Society of Toxicologic Pathology</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope><scope>5PM</scope></search><sort><creationdate>20220101</creationdate><title>Histopathology of acute colchicine intoxication: novel findings and their association with clinical manifestations</title><author>Ichimata, Shojiro ; Hata, Yukiko ; Hirota, Kojiro ; Nishida, Naoki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c467t-3a8aa568d304926bb2ce890c910f8582ad4da055439fd6007846dda738b088713</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Autopsies</topic><topic>Autopsy</topic><topic>Blood levels</topic><topic>Case Report</topic><topic>Central nervous system</topic><topic>Cerebellum</topic><topic>Colchicine</topic><topic>Degeneration</topic><topic>Dentate nucleus</topic><topic>Fatalities</topic><topic>heart</topic><topic>Histopathology</topic><topic>Ingestion</topic><topic>Intoxication</topic><topic>lipid droplets</topic><topic>Lipids</topic><topic>mitochondria</topic><topic>Nucleus ambiguus</topic><topic>Reye’s syndrome</topic><topic>Solitary tract nucleus</topic><topic>Suicide</topic><toplevel>online_resources</toplevel><creatorcontrib>Ichimata, Shojiro</creatorcontrib><creatorcontrib>Hata, Yukiko</creatorcontrib><creatorcontrib>Hirota, Kojiro</creatorcontrib><creatorcontrib>Nishida, Naoki</creatorcontrib><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of Toxicologic Pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ichimata, Shojiro</au><au>Hata, Yukiko</au><au>Hirota, Kojiro</au><au>Nishida, Naoki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Histopathology of acute colchicine intoxication: novel findings and their association with clinical manifestations</atitle><jtitle>Journal of Toxicologic Pathology</jtitle><addtitle>J Toxicol Pathol</addtitle><date>2022-01-01</date><risdate>2022</risdate><volume>35</volume><issue>3</issue><spage>255</spage><epage>262</epage><pages>255-262</pages><artnum>2022-0007</artnum><issn>0914-9198</issn><eissn>1881-915X</eissn><eissn>1347-7404</eissn><abstract>A 32-year-old woman attempted suicide by ingesting Gloriosa bulbs and died approximately 2 days later. Toxicological examination revealed a potentially fatal blood concentration of colchicine (0.096 mg/L). In addition to the increased mitotic figures in the gastrointestinal mucosa, a unique finding for acute colchicine intoxication, pathological examination showed microvesicular lipid droplets in the liver, kidney, heart, and conduction system. Furthermore, central chromatolysis of neurons was observed in the pontine nucleus, medial accessory olivary nucleus, nucleus of the solitary tract, and nucleus ambiguus. Grumose degeneration of the cerebellar dentate nucleus was also evident. These pathological findings may help identify colchicine intoxication, even in the absence of evidence suggesting ingestion during autopsy. Moreover, pathological changes in the heart and central nervous system may be associated with the development of serious complications of acute colchicine intoxication.</abstract><cop>Tokyo</cop><pub>JAPANESE SOCIETY OF TOXICOLOGIC PATHOLOGY</pub><pmid>35832901</pmid><doi>10.1293/tox.2022-0007</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of Toxicologic Pathology, 2022, Vol.35(3), pp.255-262 |
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| language | eng |
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| source | J-STAGE Free; PubMed Central Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Autopsies Autopsy Blood levels Case Report Central nervous system Cerebellum Colchicine Degeneration Dentate nucleus Fatalities heart Histopathology Ingestion Intoxication lipid droplets Lipids mitochondria Nucleus ambiguus Reye’s syndrome Solitary tract nucleus Suicide |
| title | Histopathology of acute colchicine intoxication: novel findings and their association with clinical manifestations |
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