CBX4 contributes to HIV‐1 latency by forming phase‐separated nuclear bodies and SUMOylating EZH2

The retrovirus HIV‐1 integrates into the host genome and establishes a latent viral reservoir that escapes immune surveillance. Molecular mechanisms of HIV‐1 latency have been studied extensively to achieve a cure for the acquired immunodeficiency syndrome (AIDS). Latency‐reversing agents (LRAs) hav...

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Veröffentlicht in:	EMBO reports 2022-07, Vol.23 (7), p.e53855-n/a
Hauptverfasser:	Wu, Liyang, Pan, Ting, Zhou, Mo, Chen, Tao, Wu, Shiyu, Lv, Xi, Liu, Jun, Yu, Fei, Guan, Yuanjun, Liu, Bingfeng, Zhang, Wanying, Deng, Xiaohui, Chen, Qianyu, Liang, Anqi, Lin, Yingtong, Wang, Lilin, Tang, Xiaoping, Cai, Weiping, Li, Linghua, He, Xin, Zhang, Hui, Ma, Xiancai
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired immune deficiency syndrome AIDS Catalytic activity CBX4 CD4 antigen CD4-Positive T-Lymphocytes EMBO09 EMBO23 EMBO31 Enhancer of Zeste Homolog 2 Protein - genetics Genomes HIV HIV Infections HIV-1 - genetics HIV‐1 latency Human immunodeficiency virus Humans Immune system Immunodeficiency Immunosurveillance Latency Ligases Liquid phases Long terminal repeat Lymphocytes Lymphocytes T Methyltransferase Molecular modelling Nuclear Bodies nuclear body Phase separation Polycomb group proteins Polycomb Repressive Complex 1 Polycomb-Group Proteins - genetics Proteins SUMO protein SUMOylation Therapeutic targets Ubiquitin-protein ligase Virus Latency - genetics
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