Control of innate immunity by the cGAS‐STING pathway

Within the cytoplasm of mammalian cells is a protein called cyclic GMP‐AMP synthase (cGAS), which acts to defend against infection and other threats to the host. cGAS operates in this manner through its ability to detect a molecular occurrence that should not exist in healthy cells – the existence o...

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Veröffentlicht in:	Immunology and cell biology 2022-07, Vol.100 (6), p.409-423
Hauptverfasser:	Mosallanejad, Kenta, Kagan, Jonathan C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals antiviral response Autophagy Cellular stress response cGAS Cyclic GMP Cytoplasm Cytosol Deoxyribonucleic acid DNA Endoplasmic reticulum Enzymatic activity Homeostasis Immune response Immunity, Innate Inflammation innate immune system Innate immunity Interferon Interferons Mammalian cells Mammals Membrane Proteins - metabolism Nucleotidyltransferases - genetics Nucleotidyltransferases - metabolism STING
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