Metabolomics in pediatric lower respiratory tract infections and sepsis: a literature review
Lower respiratory tract infections (LRTIs) are a leading cause of morbidity and mortality in children. The ability of healthcare providers to diagnose and prognose LRTIs in the pediatric population remains a challenge, as children can present with similar clinical features regardless of the underlyi...
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| Veröffentlicht in: | Pediatric research 2023-02, Vol.93 (3), p.492-502 |
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| container_title | Pediatric research |
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| creator | Wildman, Emily Mickiewicz, Beata Vogel, Hans J. Thompson, Graham C. |
| description | Lower respiratory tract infections (LRTIs) are a leading cause of morbidity and mortality in children. The ability of healthcare providers to diagnose and prognose LRTIs in the pediatric population remains a challenge, as children can present with similar clinical features regardless of the underlying pathogen or ultimate severity. Metabolomics, the large-scale analysis of metabolites and metabolic pathways offers new tools and insights that may aid in diagnosing and predicting the outcomes of LRTIs in children. This review highlights the latest literature on the clinical utility of metabolomics in providing care for children with bronchiolitis, pneumonia, COVID-19, and sepsis.
Impact
This article summarizes current metabolomics approaches to diagnosing and predicting the course of pediatric lower respiratory infections.
This article highlights the limitations to current metabolomics research and highlights future directions for the field. |
| doi_str_mv | 10.1038/s41390-022-02162-0 |
| format | Article |
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Impact
This article summarizes current metabolomics approaches to diagnosing and predicting the course of pediatric lower respiratory infections.
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Impact
This article summarizes current metabolomics approaches to diagnosing and predicting the course of pediatric lower respiratory infections.
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Impact
This article summarizes current metabolomics approaches to diagnosing and predicting the course of pediatric lower respiratory infections.
This article highlights the limitations to current metabolomics research and highlights future directions for the field.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>35778499</pmid><doi>10.1038/s41390-022-02162-0</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Springer Nature - Complete Springer Journals; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Child COVID-19 Humans Medical diagnosis Medicine Medicine & Public Health Metabolites Metabolomics Pediatric Surgery Pediatrics Pneumonia - diagnosis Respiratory diseases Respiratory Tract Infections - diagnosis Respiratory Tract Infections - epidemiology Review Review Article Sepsis Sepsis - diagnosis |
| title | Metabolomics in pediatric lower respiratory tract infections and sepsis: a literature review |
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