Eicosatetraynoic Acid and Butyrate Regulate Human Intestinal Organoid Mitochondrial and Extracellular Matrix Pathways Implicated in Crohn’s Disease Strictures

Abstract Background Perturbagen analysis of Crohn’s disease (CD) ileal gene expression data identified small molecules including eicosatetraynoic acid (ETYA), which may exert an antifibrotic effect. We developed a patient-specific human intestinal organoid (HIO) model system to test small molecule r...

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Veröffentlicht in:	Inflammatory bowel diseases 2022-07, Vol.28 (7), p.988-1003
Hauptverfasser:	Jurickova, Ingrid, Bonkowski, Erin, Angerman, Elizabeth, Novak, Elizabeth, Huron, Alex, Akers, Grayce, Iwasawa, Kentaro, Braun, Tzipi, Hadar, Rotem, Hooker, Maria, Han, Sarah, Cutler, David J, Okou, David T, Kugathasan, Subra, Jegga, Anil, Wells, James, Takebe, Takanori, Mollen, Kevin P, Haberman, Yael, Denson, Lee A
Format:	Artikel
Sprache:	eng
Schlagworte:	Butyrates - metabolism Butyrates - pharmacology Collagen - metabolism Constriction, Pathologic - metabolism Crohn Disease - genetics Dual Oxidases - metabolism Editor's Choice Extracellular Matrix - metabolism Humans Intestinal Mucosa - metabolism Leading Off Mitochondria - metabolism Organoids - metabolism
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