Curcumin Plant for Colorectal Cancer Prediction and Prevention Using In Silico Molecular Analysis; HOT-MELT Extrusion
The impact of a soluble complex (SC) of curcumin (CuR) synthesized using hot melt (HM) and hot-melt extrusion (HE) technologies on adenocarcinoma cells for the treatment of colorectal cancer by enhancing CuR solubility is investigated in this work. In silico molecular modelling, solubility, drug rel...
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| creator | Muthu Mohamed, Jamal Moideen Kavitha, Karuppaiyan Ahmad, Fazil Sherbiny, Mohamed El Ebrahim, Doaa EL-Sagheer, Aida M. Ebrahim, Hasnaa Ali Abdelmonem Elsherbini, Dalia Mahmoud Ebrahim Abdelrahman, Mosaab Abdella Dejene, Minilu |
| description | The impact of a soluble complex (SC) of curcumin (CuR) synthesized using hot melt (HM) and hot-melt extrusion (HE) technologies on adenocarcinoma cells for the treatment of colorectal cancer by enhancing CuR solubility is investigated in this work. In silico molecular modelling, solubility, drug release, and physicochemical analysis were all part of the phase solubility (PS) study, which featured a novel dyeing test and a central composite design to optimize the best complex (CDD). The optimal HE-SC (1 : 5) enhances solubility (0.8521 ± 0.016 mg·mL−1) and dissolution (91.87 ± 0.208% at 30 min), and it has an ideal stability constant (309 and 377 M−1) at 25 and 37°C and an AL type of isotherm, implying 1 : 1 stoichiometry according to the findings. An intermolecular hydrogen bond that has not undergone any chemical change and has resulted in the complete conversion of the amorphous form aids in the creation of SC. In vitro cytotoxicity was measured at IC50 on the SW480 (72 M·mL−1) and Caco-2 (40 M·mL−1) cells. According to apoptotic studies, apoptosis was responsible for the vast majority of cell death, with necrosis accounting for a small proportion of the total. In vivo toxicity was established using a zebrafish model, and a western blot examination revealed apoptosis at the molecular level. It was argued that the novel formulations developed using HE technology are more significant and effective than existing pure CuR formulations. |
| doi_str_mv | 10.1155/2022/4376960 |
| format | Article |
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In silico molecular modelling, solubility, drug release, and physicochemical analysis were all part of the phase solubility (PS) study, which featured a novel dyeing test and a central composite design to optimize the best complex (CDD). The optimal HE-SC (1 : 5) enhances solubility (0.8521 ± 0.016 mg·mL−1) and dissolution (91.87 ± 0.208% at 30 min), and it has an ideal stability constant (309 and 377 M−1) at 25 and 37°C and an AL type of isotherm, implying 1 : 1 stoichiometry according to the findings. An intermolecular hydrogen bond that has not undergone any chemical change and has resulted in the complete conversion of the amorphous form aids in the creation of SC. In vitro cytotoxicity was measured at IC50 on the SW480 (72 M·mL−1) and Caco-2 (40 M·mL−1) cells. According to apoptotic studies, apoptosis was responsible for the vast majority of cell death, with necrosis accounting for a small proportion of the total. In vivo toxicity was established using a zebrafish model, and a western blot examination revealed apoptosis at the molecular level. It was argued that the novel formulations developed using HE technology are more significant and effective than existing pure CuR formulations.</description><identifier>ISSN: 1741-427X</identifier><identifier>EISSN: 1741-4288</identifier><identifier>DOI: 10.1155/2022/4376960</identifier><identifier>PMID: 35783520</identifier><language>eng</language><publisher>New York: Hindawi</publisher><subject>Adenocarcinoma ; Apoptosis ; Bioavailability ; Cell death ; Colorectal cancer ; Colorectal carcinoma ; Curcumin ; Cytotoxicity ; Drugs ; Lipids ; Molecular modelling ; Permeability ; Pharmaceutical industry ; Polyps ; Solid solutions ; Solubility ; Stoichiometry</subject><ispartof>Evidence-based complementary and alternative medicine, 2022-06, Vol.2022, p.1-15</ispartof><rights>Copyright © 2022 Jamal Moideen Muthu Mohamed et al.</rights><rights>Copyright © 2022 Jamal Moideen Muthu Mohamed et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2022 Jamal Moideen Muthu Mohamed et al. 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c425t-f10e5fcc1a0e2a1e46398e55c5412aaeab96fc2472a1eca7d9b96dcbd7951ea83</citedby><cites>FETCH-LOGICAL-c425t-f10e5fcc1a0e2a1e46398e55c5412aaeab96fc2472a1eca7d9b96dcbd7951ea83</cites><orcidid>0000-0002-0814-1743 ; 0000-0001-9194-9649 ; 0000-0002-1793-928X ; 0000-0003-1509-214X ; 0000-0001-6362-8629</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9246566/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9246566/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,729,782,786,887,27931,27932,53798,53800</link.rule.ids></links><search><contributor>Roy, Arpita</contributor><contributor>Arpita Roy</contributor><creatorcontrib>Muthu Mohamed, Jamal Moideen</creatorcontrib><creatorcontrib>Kavitha, Karuppaiyan</creatorcontrib><creatorcontrib>Ahmad, Fazil</creatorcontrib><creatorcontrib>Sherbiny, Mohamed El</creatorcontrib><creatorcontrib>Ebrahim, Doaa</creatorcontrib><creatorcontrib>EL-Sagheer, Aida M.</creatorcontrib><creatorcontrib>Ebrahim, Hasnaa Ali</creatorcontrib><creatorcontrib>Abdelmonem Elsherbini, Dalia Mahmoud</creatorcontrib><creatorcontrib>Ebrahim Abdelrahman, Mosaab Abdella</creatorcontrib><creatorcontrib>Dejene, Minilu</creatorcontrib><title>Curcumin Plant for Colorectal Cancer Prediction and Prevention Using In Silico Molecular Analysis; HOT-MELT Extrusion</title><title>Evidence-based complementary and alternative medicine</title><description>The impact of a soluble complex (SC) of curcumin (CuR) synthesized using hot melt (HM) and hot-melt extrusion (HE) technologies on adenocarcinoma cells for the treatment of colorectal cancer by enhancing CuR solubility is investigated in this work. 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HOT-MELT Extrusion</title><author>Muthu Mohamed, Jamal Moideen ; Kavitha, Karuppaiyan ; Ahmad, Fazil ; Sherbiny, Mohamed El ; Ebrahim, Doaa ; EL-Sagheer, Aida M. ; Ebrahim, Hasnaa Ali ; Abdelmonem Elsherbini, Dalia Mahmoud ; Ebrahim Abdelrahman, Mosaab Abdella ; Dejene, Minilu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c425t-f10e5fcc1a0e2a1e46398e55c5412aaeab96fc2472a1eca7d9b96dcbd7951ea83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Adenocarcinoma</topic><topic>Apoptosis</topic><topic>Bioavailability</topic><topic>Cell death</topic><topic>Colorectal cancer</topic><topic>Colorectal carcinoma</topic><topic>Curcumin</topic><topic>Cytotoxicity</topic><topic>Drugs</topic><topic>Lipids</topic><topic>Molecular modelling</topic><topic>Permeability</topic><topic>Pharmaceutical industry</topic><topic>Polyps</topic><topic>Solid solutions</topic><topic>Solubility</topic><topic>Stoichiometry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Muthu Mohamed, Jamal Moideen</creatorcontrib><creatorcontrib>Kavitha, Karuppaiyan</creatorcontrib><creatorcontrib>Ahmad, Fazil</creatorcontrib><creatorcontrib>Sherbiny, Mohamed El</creatorcontrib><creatorcontrib>Ebrahim, Doaa</creatorcontrib><creatorcontrib>EL-Sagheer, Aida M.</creatorcontrib><creatorcontrib>Ebrahim, Hasnaa Ali</creatorcontrib><creatorcontrib>Abdelmonem Elsherbini, Dalia Mahmoud</creatorcontrib><creatorcontrib>Ebrahim Abdelrahman, Mosaab Abdella</creatorcontrib><creatorcontrib>Dejene, Minilu</creatorcontrib><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access Journals</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Nursing and Allied Health Journals</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>ProQuest Health and Medical</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest Psychology Journals</collection><collection>ProQuest Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Evidence-based complementary and alternative medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Muthu Mohamed, Jamal Moideen</au><au>Kavitha, Karuppaiyan</au><au>Ahmad, Fazil</au><au>Sherbiny, Mohamed El</au><au>Ebrahim, Doaa</au><au>EL-Sagheer, Aida M.</au><au>Ebrahim, Hasnaa Ali</au><au>Abdelmonem Elsherbini, Dalia Mahmoud</au><au>Ebrahim Abdelrahman, Mosaab Abdella</au><au>Dejene, Minilu</au><au>Roy, Arpita</au><au>Arpita Roy</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Curcumin Plant for Colorectal Cancer Prediction and Prevention Using In Silico Molecular Analysis; HOT-MELT Extrusion</atitle><jtitle>Evidence-based complementary and alternative medicine</jtitle><date>2022-06-23</date><risdate>2022</risdate><volume>2022</volume><spage>1</spage><epage>15</epage><pages>1-15</pages><issn>1741-427X</issn><eissn>1741-4288</eissn><abstract>The impact of a soluble complex (SC) of curcumin (CuR) synthesized using hot melt (HM) and hot-melt extrusion (HE) technologies on adenocarcinoma cells for the treatment of colorectal cancer by enhancing CuR solubility is investigated in this work. In silico molecular modelling, solubility, drug release, and physicochemical analysis were all part of the phase solubility (PS) study, which featured a novel dyeing test and a central composite design to optimize the best complex (CDD). The optimal HE-SC (1 : 5) enhances solubility (0.8521 ± 0.016 mg·mL−1) and dissolution (91.87 ± 0.208% at 30 min), and it has an ideal stability constant (309 and 377 M−1) at 25 and 37°C and an AL type of isotherm, implying 1 : 1 stoichiometry according to the findings. An intermolecular hydrogen bond that has not undergone any chemical change and has resulted in the complete conversion of the amorphous form aids in the creation of SC. In vitro cytotoxicity was measured at IC50 on the SW480 (72 M·mL−1) and Caco-2 (40 M·mL−1) cells. According to apoptotic studies, apoptosis was responsible for the vast majority of cell death, with necrosis accounting for a small proportion of the total. 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| subjects | Adenocarcinoma Apoptosis Bioavailability Cell death Colorectal cancer Colorectal carcinoma Curcumin Cytotoxicity Drugs Lipids Molecular modelling Permeability Pharmaceutical industry Polyps Solid solutions Solubility Stoichiometry |
| title | Curcumin Plant for Colorectal Cancer Prediction and Prevention Using In Silico Molecular Analysis; HOT-MELT Extrusion |
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