Insight into the impacts and mechanisms of ketone stress on the antibiotic resistance in Escherichia coli
Accumulation of toxic organic has posed a substantial pressure on the proliferation of bacterial resistance. While aromatic organics have been demonstrated to enhance the antibiotic resistance in bacteria, no information is yet available on the effects of non-aromatic organics on the variations of b...
Gespeichert in:
| Veröffentlicht in: | Environmental science and pollution research international 2022-11, Vol.29 (55), p.83746-83755 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 83755 |
|---|---|
| container_issue | 55 |
| container_start_page | 83746 |
| container_title | Environmental science and pollution research international |
| container_volume | 29 |
| creator | Tang, Zhenping Zhang, Yu Xiao, Shasha Gao, Yuanyuan Duan, Yi Liu, Boyang Xiong, Cong Yang, Zhengqing Wu, Yueyue Zhou, Shuai |
| description | Accumulation of toxic organic has posed a substantial pressure on the proliferation of bacterial resistance. While aromatic organics have been demonstrated to enhance the antibiotic resistance in bacteria, no information is yet available on the effects of non-aromatic organics on the variations of bacterial resistance. Here, we investigated the effects of a typical ketone (i.e., methylisobutanone (MIBK)) on the variations of antibiotic resistance in
Escherichia coli
(
E. coli
). The results showed that the growth of resistant
E. coli
under environmental concentration of 50 μg/L MIBK was firstly inhibited as explained by the transient disruption in the cell membrane and then recovered possibly due to the reactive oxygen species. Exposure to 50 μg/L MIBK gradually raised the abundance of representative resistance gene (
ampR
) in
E. coli
. In contrast, the high concentration of 50 mg/L MIBK continuously inhibited the growth of resistant
E. coli
by disrupting cell membrane and notably promoted the proliferation of
ampR
through enhancing the horizontal transformation and up-regulating the expression of efflux pump gene. These findings provided the first evidence for the evolution of bacterial resistance in response to ketone organics. |
| doi_str_mv | 10.1007/s11356-022-21600-4 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9245865</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2733854145</sourcerecordid><originalsourceid>FETCH-LOGICAL-c474t-38807f062b22bb1578a0f46883643cc365b2a01d51456df9da072e28436003fe3</originalsourceid><addsrcrecordid>eNp9kctuFDEQRS0EIpOEH2CBLLFh0-C33RskFIUQKRIbsrbcbve0Q7c9uDyR-HucTAiPRVYlVZ269bgIvabkPSVEfwBKuVQdYaxjVBHSiWdoQxUVnRZ9_xxtSC9ER7kQR-gY4IYQRnqmX6IjLrWmnNMNipcJ4nauOKaacZ0DjuvO-QrYpRGvwc8uRVgB5wl_DzWngKGWAC2R7nGXahxirtHjlo5QXfJNJOFz8HMo0c_RYZ-XeIpeTG6B8OohnqDrz-ffzr50V18vLs8-XXVeaFE7bgzRE1FsYGwYqNTGkUkoY7gS3Huu5MAcoaOkQqpx6kdHNAvMCN4-wKfAT9DHg-5uP6xh9CHV4ha7K3F15afNLtp_KynOdptvbc-ENEo2gXcPAiX_2Aeodo3gw7K4FPIeLFOGaSOYMA19-x96k_cltfMs05wbKdqWjWIHypcMUML0uAwl9s5Je3DSNiftvZNWtKY3f5_x2PLbugbwAwCtlLah_Jn9hOwv3sqpoA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2733854145</pqid></control><display><type>article</type><title>Insight into the impacts and mechanisms of ketone stress on the antibiotic resistance in Escherichia coli</title><source>MEDLINE</source><source>SpringerNature Journals</source><creator>Tang, Zhenping ; Zhang, Yu ; Xiao, Shasha ; Gao, Yuanyuan ; Duan, Yi ; Liu, Boyang ; Xiong, Cong ; Yang, Zhengqing ; Wu, Yueyue ; Zhou, Shuai</creator><creatorcontrib>Tang, Zhenping ; Zhang, Yu ; Xiao, Shasha ; Gao, Yuanyuan ; Duan, Yi ; Liu, Boyang ; Xiong, Cong ; Yang, Zhengqing ; Wu, Yueyue ; Zhou, Shuai</creatorcontrib><description>Accumulation of toxic organic has posed a substantial pressure on the proliferation of bacterial resistance. While aromatic organics have been demonstrated to enhance the antibiotic resistance in bacteria, no information is yet available on the effects of non-aromatic organics on the variations of bacterial resistance. Here, we investigated the effects of a typical ketone (i.e., methylisobutanone (MIBK)) on the variations of antibiotic resistance in
Escherichia coli
(
E. coli
). The results showed that the growth of resistant
E. coli
under environmental concentration of 50 μg/L MIBK was firstly inhibited as explained by the transient disruption in the cell membrane and then recovered possibly due to the reactive oxygen species. Exposure to 50 μg/L MIBK gradually raised the abundance of representative resistance gene (
ampR
) in
E. coli
. In contrast, the high concentration of 50 mg/L MIBK continuously inhibited the growth of resistant
E. coli
by disrupting cell membrane and notably promoted the proliferation of
ampR
through enhancing the horizontal transformation and up-regulating the expression of efflux pump gene. These findings provided the first evidence for the evolution of bacterial resistance in response to ketone organics.</description><identifier>ISSN: 0944-1344</identifier><identifier>ISSN: 1614-7499</identifier><identifier>EISSN: 1614-7499</identifier><identifier>DOI: 10.1007/s11356-022-21600-4</identifier><identifier>PMID: 35771331</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Anti-Bacterial Agents - pharmacology ; Antibiotic resistance ; Antibiotics ; Aquatic Pollution ; Atmospheric Protection/Air Quality Control/Air Pollution ; Bacteria ; Bacteria - genetics ; Cell membranes ; Disruption ; Drug resistance ; Drug Resistance, Microbial ; E coli ; Earth and Environmental Science ; Ecotoxicology ; Efflux ; Environment ; Environmental Chemistry ; Environmental Health ; Environmental science ; Escherichia coli ; Gene expression ; Genes, Bacterial ; Ketones ; Ketones - pharmacology ; Reactive oxygen species ; Research Article ; Waste Water Technology ; Water Management ; Water Pollution Control</subject><ispartof>Environmental science and pollution research international, 2022-11, Vol.29 (55), p.83746-83755</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022</rights><rights>2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.</rights><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-38807f062b22bb1578a0f46883643cc365b2a01d51456df9da072e28436003fe3</citedby><cites>FETCH-LOGICAL-c474t-38807f062b22bb1578a0f46883643cc365b2a01d51456df9da072e28436003fe3</cites><orcidid>0000-0002-5906-2607</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11356-022-21600-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11356-022-21600-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,315,781,785,886,27929,27930,41493,42562,51324</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35771331$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tang, Zhenping</creatorcontrib><creatorcontrib>Zhang, Yu</creatorcontrib><creatorcontrib>Xiao, Shasha</creatorcontrib><creatorcontrib>Gao, Yuanyuan</creatorcontrib><creatorcontrib>Duan, Yi</creatorcontrib><creatorcontrib>Liu, Boyang</creatorcontrib><creatorcontrib>Xiong, Cong</creatorcontrib><creatorcontrib>Yang, Zhengqing</creatorcontrib><creatorcontrib>Wu, Yueyue</creatorcontrib><creatorcontrib>Zhou, Shuai</creatorcontrib><title>Insight into the impacts and mechanisms of ketone stress on the antibiotic resistance in Escherichia coli</title><title>Environmental science and pollution research international</title><addtitle>Environ Sci Pollut Res</addtitle><addtitle>Environ Sci Pollut Res Int</addtitle><description>Accumulation of toxic organic has posed a substantial pressure on the proliferation of bacterial resistance. While aromatic organics have been demonstrated to enhance the antibiotic resistance in bacteria, no information is yet available on the effects of non-aromatic organics on the variations of bacterial resistance. Here, we investigated the effects of a typical ketone (i.e., methylisobutanone (MIBK)) on the variations of antibiotic resistance in
Escherichia coli
(
E. coli
). The results showed that the growth of resistant
E. coli
under environmental concentration of 50 μg/L MIBK was firstly inhibited as explained by the transient disruption in the cell membrane and then recovered possibly due to the reactive oxygen species. Exposure to 50 μg/L MIBK gradually raised the abundance of representative resistance gene (
ampR
) in
E. coli
. In contrast, the high concentration of 50 mg/L MIBK continuously inhibited the growth of resistant
E. coli
by disrupting cell membrane and notably promoted the proliferation of
ampR
through enhancing the horizontal transformation and up-regulating the expression of efflux pump gene. These findings provided the first evidence for the evolution of bacterial resistance in response to ketone organics.</description><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Antibiotic resistance</subject><subject>Antibiotics</subject><subject>Aquatic Pollution</subject><subject>Atmospheric Protection/Air Quality Control/Air Pollution</subject><subject>Bacteria</subject><subject>Bacteria - genetics</subject><subject>Cell membranes</subject><subject>Disruption</subject><subject>Drug resistance</subject><subject>Drug Resistance, Microbial</subject><subject>E coli</subject><subject>Earth and Environmental Science</subject><subject>Ecotoxicology</subject><subject>Efflux</subject><subject>Environment</subject><subject>Environmental Chemistry</subject><subject>Environmental Health</subject><subject>Environmental science</subject><subject>Escherichia coli</subject><subject>Gene expression</subject><subject>Genes, Bacterial</subject><subject>Ketones</subject><subject>Ketones - pharmacology</subject><subject>Reactive oxygen species</subject><subject>Research Article</subject><subject>Waste Water Technology</subject><subject>Water Management</subject><subject>Water Pollution Control</subject><issn>0944-1344</issn><issn>1614-7499</issn><issn>1614-7499</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kctuFDEQRS0EIpOEH2CBLLFh0-C33RskFIUQKRIbsrbcbve0Q7c9uDyR-HucTAiPRVYlVZ269bgIvabkPSVEfwBKuVQdYaxjVBHSiWdoQxUVnRZ9_xxtSC9ER7kQR-gY4IYQRnqmX6IjLrWmnNMNipcJ4nauOKaacZ0DjuvO-QrYpRGvwc8uRVgB5wl_DzWngKGWAC2R7nGXahxirtHjlo5QXfJNJOFz8HMo0c_RYZ-XeIpeTG6B8OohnqDrz-ffzr50V18vLs8-XXVeaFE7bgzRE1FsYGwYqNTGkUkoY7gS3Huu5MAcoaOkQqpx6kdHNAvMCN4-wKfAT9DHg-5uP6xh9CHV4ha7K3F15afNLtp_KynOdptvbc-ENEo2gXcPAiX_2Aeodo3gw7K4FPIeLFOGaSOYMA19-x96k_cltfMs05wbKdqWjWIHypcMUML0uAwl9s5Je3DSNiftvZNWtKY3f5_x2PLbugbwAwCtlLah_Jn9hOwv3sqpoA</recordid><startdate>20221101</startdate><enddate>20221101</enddate><creator>Tang, Zhenping</creator><creator>Zhang, Yu</creator><creator>Xiao, Shasha</creator><creator>Gao, Yuanyuan</creator><creator>Duan, Yi</creator><creator>Liu, Boyang</creator><creator>Xiong, Cong</creator><creator>Yang, Zhengqing</creator><creator>Wu, Yueyue</creator><creator>Zhou, Shuai</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7SN</scope><scope>7T7</scope><scope>7TV</scope><scope>7U7</scope><scope>7WY</scope><scope>7WZ</scope><scope>7X7</scope><scope>7XB</scope><scope>87Z</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8FL</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BEZIV</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FRNLG</scope><scope>FYUFA</scope><scope>F~G</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K60</scope><scope>K6~</scope><scope>K9.</scope><scope>L.-</scope><scope>M0C</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7N</scope><scope>P64</scope><scope>PATMY</scope><scope>PQBIZ</scope><scope>PQBZA</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-5906-2607</orcidid></search><sort><creationdate>20221101</creationdate><title>Insight into the impacts and mechanisms of ketone stress on the antibiotic resistance in Escherichia coli</title><author>Tang, Zhenping ; Zhang, Yu ; Xiao, Shasha ; Gao, Yuanyuan ; Duan, Yi ; Liu, Boyang ; Xiong, Cong ; Yang, Zhengqing ; Wu, Yueyue ; Zhou, Shuai</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-38807f062b22bb1578a0f46883643cc365b2a01d51456df9da072e28436003fe3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Antibiotic resistance</topic><topic>Antibiotics</topic><topic>Aquatic Pollution</topic><topic>Atmospheric Protection/Air Quality Control/Air Pollution</topic><topic>Bacteria</topic><topic>Bacteria - genetics</topic><topic>Cell membranes</topic><topic>Disruption</topic><topic>Drug resistance</topic><topic>Drug Resistance, Microbial</topic><topic>E coli</topic><topic>Earth and Environmental Science</topic><topic>Ecotoxicology</topic><topic>Efflux</topic><topic>Environment</topic><topic>Environmental Chemistry</topic><topic>Environmental Health</topic><topic>Environmental science</topic><topic>Escherichia coli</topic><topic>Gene expression</topic><topic>Genes, Bacterial</topic><topic>Ketones</topic><topic>Ketones - pharmacology</topic><topic>Reactive oxygen species</topic><topic>Research Article</topic><topic>Waste Water Technology</topic><topic>Water Management</topic><topic>Water Pollution Control</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tang, Zhenping</creatorcontrib><creatorcontrib>Zhang, Yu</creatorcontrib><creatorcontrib>Xiao, Shasha</creatorcontrib><creatorcontrib>Gao, Yuanyuan</creatorcontrib><creatorcontrib>Duan, Yi</creatorcontrib><creatorcontrib>Liu, Boyang</creatorcontrib><creatorcontrib>Xiong, Cong</creatorcontrib><creatorcontrib>Yang, Zhengqing</creatorcontrib><creatorcontrib>Wu, Yueyue</creatorcontrib><creatorcontrib>Zhou, Shuai</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Ecology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Pollution Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Access via ABI/INFORM (ProQuest)</collection><collection>ABI/INFORM Global (PDF only)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ABI/INFORM Global (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ABI/INFORM Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Business Premium Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Business Premium Collection (Alumni)</collection><collection>Health Research Premium Collection</collection><collection>ABI/INFORM Global (Corporate)</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Business Collection (Alumni Edition)</collection><collection>ProQuest Business Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ABI/INFORM Professional Advanced</collection><collection>ABI/INFORM Global</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>ProQuest One Business</collection><collection>ProQuest One Business (Alumni)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Environmental Science Collection</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Environmental science and pollution research international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tang, Zhenping</au><au>Zhang, Yu</au><au>Xiao, Shasha</au><au>Gao, Yuanyuan</au><au>Duan, Yi</au><au>Liu, Boyang</au><au>Xiong, Cong</au><au>Yang, Zhengqing</au><au>Wu, Yueyue</au><au>Zhou, Shuai</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Insight into the impacts and mechanisms of ketone stress on the antibiotic resistance in Escherichia coli</atitle><jtitle>Environmental science and pollution research international</jtitle><stitle>Environ Sci Pollut Res</stitle><addtitle>Environ Sci Pollut Res Int</addtitle><date>2022-11-01</date><risdate>2022</risdate><volume>29</volume><issue>55</issue><spage>83746</spage><epage>83755</epage><pages>83746-83755</pages><issn>0944-1344</issn><issn>1614-7499</issn><eissn>1614-7499</eissn><abstract>Accumulation of toxic organic has posed a substantial pressure on the proliferation of bacterial resistance. While aromatic organics have been demonstrated to enhance the antibiotic resistance in bacteria, no information is yet available on the effects of non-aromatic organics on the variations of bacterial resistance. Here, we investigated the effects of a typical ketone (i.e., methylisobutanone (MIBK)) on the variations of antibiotic resistance in
Escherichia coli
(
E. coli
). The results showed that the growth of resistant
E. coli
under environmental concentration of 50 μg/L MIBK was firstly inhibited as explained by the transient disruption in the cell membrane and then recovered possibly due to the reactive oxygen species. Exposure to 50 μg/L MIBK gradually raised the abundance of representative resistance gene (
ampR
) in
E. coli
. In contrast, the high concentration of 50 mg/L MIBK continuously inhibited the growth of resistant
E. coli
by disrupting cell membrane and notably promoted the proliferation of
ampR
through enhancing the horizontal transformation and up-regulating the expression of efflux pump gene. These findings provided the first evidence for the evolution of bacterial resistance in response to ketone organics.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>35771331</pmid><doi>10.1007/s11356-022-21600-4</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-5906-2607</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0944-1344 |
| ispartof | Environmental science and pollution research international, 2022-11, Vol.29 (55), p.83746-83755 |
| issn | 0944-1344 1614-7499 1614-7499 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9245865 |
| source | MEDLINE; SpringerNature Journals |
| subjects | Anti-Bacterial Agents - pharmacology Antibiotic resistance Antibiotics Aquatic Pollution Atmospheric Protection/Air Quality Control/Air Pollution Bacteria Bacteria - genetics Cell membranes Disruption Drug resistance Drug Resistance, Microbial E coli Earth and Environmental Science Ecotoxicology Efflux Environment Environmental Chemistry Environmental Health Environmental science Escherichia coli Gene expression Genes, Bacterial Ketones Ketones - pharmacology Reactive oxygen species Research Article Waste Water Technology Water Management Water Pollution Control |
| title | Insight into the impacts and mechanisms of ketone stress on the antibiotic resistance in Escherichia coli |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-16T00%3A48%3A37IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Insight%20into%20the%20impacts%20and%20mechanisms%20of%20ketone%20stress%20on%20the%20antibiotic%20resistance%20in%20Escherichia%20coli&rft.jtitle=Environmental%20science%20and%20pollution%20research%20international&rft.au=Tang,%20Zhenping&rft.date=2022-11-01&rft.volume=29&rft.issue=55&rft.spage=83746&rft.epage=83755&rft.pages=83746-83755&rft.issn=0944-1344&rft.eissn=1614-7499&rft_id=info:doi/10.1007/s11356-022-21600-4&rft_dat=%3Cproquest_pubme%3E2733854145%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2733854145&rft_id=info:pmid/35771331&rfr_iscdi=true |