$Potential Role of IFNγ Inhibition in Refractory Cytokine Release Syndrome Associated with CAR T-cell Therapy$

Potential Role of IFNγ Inhibition in Refractory Cytokine Release Syndrome Associated with CAR T-cell Therapy

Here we review the pathophysiology and management of cytokine release syndrome (CRS) secondary to immunotherapy, and potential options for CRS refractory to IL6 inhibition and glucocorticoids, for which there are no proven treatments. To illustrate, we describe a patient with B-cell acute lymphoblas...

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Veröffentlicht in:	Blood cancer discovery 2022-03, Vol.3 (2), p.90-94
Hauptverfasser:	McNerney, Kevin O, DiNofia, Amanda M, Teachey, David T, Grupp, Stephan A, Maude, Shannon L
Format:	Artikel
Sprache:	eng
Schlagworte:	Cytokine Release Syndrome - drug therapy Hematologic Neoplasms Humans Immunotherapy, Adoptive - adverse effects In Focus Interferon-gamma Macrophage Activation Receptors, Chimeric Antigen - immunology T-Lymphocytes
Online-Zugang:	Volltext
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