Triglyceride-glucose index predicts outcome in patients with chronic coronary syndrome independently of other risk factors and myocardial ischaemia
Aims The triglyceride-glucose (TyG) index, a surrogate marker of insulin resistance (IR), is a prognostic risk factor in the general population. We aimed to assess whether it is an independent predictor of outcome also in patients with chronic coronary syndrome (CCS). Methods and results TyG index w...
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| Veröffentlicht in: | European heart journal open 2021-08, Vol.1 (1), p.oeab004-oeab004 |
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| creator | Neglia, Danilo Aimo, Alberto Lorenzoni, Valentina Caselli, Chiara Gimelli, Alessia |
| description | Aims
The triglyceride-glucose (TyG) index, a surrogate marker of insulin resistance (IR), is a prognostic risk factor in the general population. We aimed to assess whether it is an independent predictor of outcome also in patients with chronic coronary syndrome (CCS).
Methods and results
TyG index was evaluated in 1097 consecutive patients (75% men, median age 72 years) with known (26%) or suspected coronary artery disease (CAD), undergoing stress-rest myocardial perfusion scintigraphy, and coronary angiography and followed up for a median of 4.5 years. Moderate/severe perfusion abnormalities during stress (summed stress score >7) were documented in 60% of patients, obstructive CAD in 74%, and 36% underwent early revascularization. TyG index was 8.9 (median, interquartile interval 8.6–9.2). Cardiac death or myocardial infarction occurred in 103 patients and all-cause death in 65. After correction for clinical risk factors, LV function and common bio-humoral variables, TyG index (HR 2.42, 95% CI 1.57–3.72, P |
| doi_str_mv | 10.1093/ehjopen/oeab004 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9242059</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A760851839</galeid><oup_id>10.1093/ehjopen/oeab004</oup_id><sourcerecordid>A760851839</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3874-3da1dc2e4304b69d5aa108d65677ab9748fce98ee9e48e9a7442b869f84ac79a3</originalsourceid><addsrcrecordid>eNqFkkGL1TAUhYsozjDO2m3AjQidl7Zpk2yEYdAZYcDNuA63ye1rxjapSav2d_iHTelDHBAkixtOvnO4N9wse13Qq4LK6oD9o5_QHTxCSyl7lp2XvC5zVsji-V_3s-wyxkdKaSmokAV9mZ1VtSwklew8-_UQ7HFYNQZrMD8Oi_YRiXUGf5IpoLF6jsQvs_bjJpMJZosuaT_s3BPdB--sJtqnCmElcXUm7KjB1JtJ7LAS3xE_9xhIsPEr6UDPPkQCzpBx9RqCsTAQG3UPOFp4lb3oYIh4eaoX2ZePHx5u7vL7z7efbq7vc10JzvLKQGF0iayirG2kqQEKKkxTN5xDKzkTnUYpECUygRI4Y2UrGtkJBppLqC6y93vutLQjGp16DTCoKdgxzaI8WPX0xdleHf13JUtW0lqmgLengOC_LRhnNaYhcBjAoV-iKhvJG17JckPf7OgRBlTWdT4l6g1X17yhoi5EtVFX_6DSMelftHfY2aQ_MRx2gw4-xoDdn-4LqrYlUaclUaclSY53u8Mv03_h32pew-c</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2697673929</pqid></control><display><type>article</type><title>Triglyceride-glucose index predicts outcome in patients with chronic coronary syndrome independently of other risk factors and myocardial ischaemia</title><source>Oxford Journals Open Access Collection</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><creator>Neglia, Danilo ; Aimo, Alberto ; Lorenzoni, Valentina ; Caselli, Chiara ; Gimelli, Alessia</creator><creatorcontrib>Neglia, Danilo ; Aimo, Alberto ; Lorenzoni, Valentina ; Caselli, Chiara ; Gimelli, Alessia</creatorcontrib><description>Aims
The triglyceride-glucose (TyG) index, a surrogate marker of insulin resistance (IR), is a prognostic risk factor in the general population. We aimed to assess whether it is an independent predictor of outcome also in patients with chronic coronary syndrome (CCS).
Methods and results
TyG index was evaluated in 1097 consecutive patients (75% men, median age 72 years) with known (26%) or suspected coronary artery disease (CAD), undergoing stress-rest myocardial perfusion scintigraphy, and coronary angiography and followed up for a median of 4.5 years. Moderate/severe perfusion abnormalities during stress (summed stress score >7) were documented in 60% of patients, obstructive CAD in 74%, and 36% underwent early revascularization. TyG index was 8.9 (median, interquartile interval 8.6–9.2). Cardiac death or myocardial infarction occurred in 103 patients and all-cause death in 65. After correction for clinical risk factors, LV function and common bio-humoral variables, TyG index (HR 2.42, 95% CI 1.57–3.72, P < 0.001), and moderate/severe stress perfusion abnormalities (hazard ratio (HR) 2.17, 95% confidence interval (CI) 1.25–3.77, P < 0.001) independently predicted cardiac events. TyG index (HR 3.64, 95%CI 2.22–5.96, P < 0.001) and high-sensitivity C-reactive protein (HR 1.11, 95% CI 1.04–1.19, P = 0.002) independently predicted all-cause death.
Conclusion
In patients with CCS, the TyG index identifies a cardiometabolic profile associated with an additional risk of cardiac events, over the presence of myocardial ischaemia and independently of other clinical, common bio-humoral or imaging risk determinants.
Graphical Abstract
Graphical AbstractPatients with chronic coronary symptoms were characterized by clinical variables, risk factors and common bio markers. They underwent diagnostic screening by functional and anatomical cardiac imaging and followed-up for 4.6 years. LDL cholesterol, obstructive coronary artery disease, moderate–severe myocardial ischaemia and the trygliceride-glucose index stratified the risk of cardiac events. The multivariable predictive model including trygliceride-glucose index and high-sensitivity C-reactive protein outperformed all other models.</description><identifier>ISSN: 2752-4191</identifier><identifier>EISSN: 2752-4191</identifier><identifier>DOI: 10.1093/ehjopen/oeab004</identifier><identifier>PMID: 35919094</identifier><language>eng</language><publisher>Oxford University Press</publisher><subject>Analysis ; Antilipemic agents ; Care and treatment ; Diagnosis ; Dosage and administration ; Glucose tolerance tests ; Health aspects ; Measurement ; Myocardial ischemia ; Original ; Triglycerides</subject><ispartof>European heart journal open, 2021-08, Vol.1 (1), p.oeab004-oeab004</ispartof><rights>The Author(s) 2021. Published by Oxford University Press on behalf of the European Society of Cardiology. 2021</rights><rights>COPYRIGHT 2021 Oxford University Press</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3874-3da1dc2e4304b69d5aa108d65677ab9748fce98ee9e48e9a7442b869f84ac79a3</citedby><cites>FETCH-LOGICAL-c3874-3da1dc2e4304b69d5aa108d65677ab9748fce98ee9e48e9a7442b869f84ac79a3</cites><orcidid>0000-0003-0016-9538</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9242059/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9242059/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,1598,27901,27902,53766,53768</link.rule.ids></links><search><creatorcontrib>Neglia, Danilo</creatorcontrib><creatorcontrib>Aimo, Alberto</creatorcontrib><creatorcontrib>Lorenzoni, Valentina</creatorcontrib><creatorcontrib>Caselli, Chiara</creatorcontrib><creatorcontrib>Gimelli, Alessia</creatorcontrib><title>Triglyceride-glucose index predicts outcome in patients with chronic coronary syndrome independently of other risk factors and myocardial ischaemia</title><title>European heart journal open</title><description>Aims
The triglyceride-glucose (TyG) index, a surrogate marker of insulin resistance (IR), is a prognostic risk factor in the general population. We aimed to assess whether it is an independent predictor of outcome also in patients with chronic coronary syndrome (CCS).
Methods and results
TyG index was evaluated in 1097 consecutive patients (75% men, median age 72 years) with known (26%) or suspected coronary artery disease (CAD), undergoing stress-rest myocardial perfusion scintigraphy, and coronary angiography and followed up for a median of 4.5 years. Moderate/severe perfusion abnormalities during stress (summed stress score >7) were documented in 60% of patients, obstructive CAD in 74%, and 36% underwent early revascularization. TyG index was 8.9 (median, interquartile interval 8.6–9.2). Cardiac death or myocardial infarction occurred in 103 patients and all-cause death in 65. After correction for clinical risk factors, LV function and common bio-humoral variables, TyG index (HR 2.42, 95% CI 1.57–3.72, P < 0.001), and moderate/severe stress perfusion abnormalities (hazard ratio (HR) 2.17, 95% confidence interval (CI) 1.25–3.77, P < 0.001) independently predicted cardiac events. TyG index (HR 3.64, 95%CI 2.22–5.96, P < 0.001) and high-sensitivity C-reactive protein (HR 1.11, 95% CI 1.04–1.19, P = 0.002) independently predicted all-cause death.
Conclusion
In patients with CCS, the TyG index identifies a cardiometabolic profile associated with an additional risk of cardiac events, over the presence of myocardial ischaemia and independently of other clinical, common bio-humoral or imaging risk determinants.
Graphical Abstract
Graphical AbstractPatients with chronic coronary symptoms were characterized by clinical variables, risk factors and common bio markers. They underwent diagnostic screening by functional and anatomical cardiac imaging and followed-up for 4.6 years. LDL cholesterol, obstructive coronary artery disease, moderate–severe myocardial ischaemia and the trygliceride-glucose index stratified the risk of cardiac events. The multivariable predictive model including trygliceride-glucose index and high-sensitivity C-reactive protein outperformed all other models.</description><subject>Analysis</subject><subject>Antilipemic agents</subject><subject>Care and treatment</subject><subject>Diagnosis</subject><subject>Dosage and administration</subject><subject>Glucose tolerance tests</subject><subject>Health aspects</subject><subject>Measurement</subject><subject>Myocardial ischemia</subject><subject>Original</subject><subject>Triglycerides</subject><issn>2752-4191</issn><issn>2752-4191</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>TOX</sourceid><recordid>eNqFkkGL1TAUhYsozjDO2m3AjQidl7Zpk2yEYdAZYcDNuA63ye1rxjapSav2d_iHTelDHBAkixtOvnO4N9wse13Qq4LK6oD9o5_QHTxCSyl7lp2XvC5zVsji-V_3s-wyxkdKaSmokAV9mZ1VtSwklew8-_UQ7HFYNQZrMD8Oi_YRiXUGf5IpoLF6jsQvs_bjJpMJZosuaT_s3BPdB--sJtqnCmElcXUm7KjB1JtJ7LAS3xE_9xhIsPEr6UDPPkQCzpBx9RqCsTAQG3UPOFp4lb3oYIh4eaoX2ZePHx5u7vL7z7efbq7vc10JzvLKQGF0iayirG2kqQEKKkxTN5xDKzkTnUYpECUygRI4Y2UrGtkJBppLqC6y93vutLQjGp16DTCoKdgxzaI8WPX0xdleHf13JUtW0lqmgLengOC_LRhnNaYhcBjAoV-iKhvJG17JckPf7OgRBlTWdT4l6g1X17yhoi5EtVFX_6DSMelftHfY2aQ_MRx2gw4-xoDdn-4LqrYlUaclUaclSY53u8Mv03_h32pew-c</recordid><startdate>20210801</startdate><enddate>20210801</enddate><creator>Neglia, Danilo</creator><creator>Aimo, Alberto</creator><creator>Lorenzoni, Valentina</creator><creator>Caselli, Chiara</creator><creator>Gimelli, Alessia</creator><general>Oxford University Press</general><scope>TOX</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-0016-9538</orcidid></search><sort><creationdate>20210801</creationdate><title>Triglyceride-glucose index predicts outcome in patients with chronic coronary syndrome independently of other risk factors and myocardial ischaemia</title><author>Neglia, Danilo ; Aimo, Alberto ; Lorenzoni, Valentina ; Caselli, Chiara ; Gimelli, Alessia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3874-3da1dc2e4304b69d5aa108d65677ab9748fce98ee9e48e9a7442b869f84ac79a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Analysis</topic><topic>Antilipemic agents</topic><topic>Care and treatment</topic><topic>Diagnosis</topic><topic>Dosage and administration</topic><topic>Glucose tolerance tests</topic><topic>Health aspects</topic><topic>Measurement</topic><topic>Myocardial ischemia</topic><topic>Original</topic><topic>Triglycerides</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Neglia, Danilo</creatorcontrib><creatorcontrib>Aimo, Alberto</creatorcontrib><creatorcontrib>Lorenzoni, Valentina</creatorcontrib><creatorcontrib>Caselli, Chiara</creatorcontrib><creatorcontrib>Gimelli, Alessia</creatorcontrib><collection>Oxford Journals Open Access Collection</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>European heart journal open</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Neglia, Danilo</au><au>Aimo, Alberto</au><au>Lorenzoni, Valentina</au><au>Caselli, Chiara</au><au>Gimelli, Alessia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Triglyceride-glucose index predicts outcome in patients with chronic coronary syndrome independently of other risk factors and myocardial ischaemia</atitle><jtitle>European heart journal open</jtitle><date>2021-08-01</date><risdate>2021</risdate><volume>1</volume><issue>1</issue><spage>oeab004</spage><epage>oeab004</epage><pages>oeab004-oeab004</pages><issn>2752-4191</issn><eissn>2752-4191</eissn><abstract>Aims
The triglyceride-glucose (TyG) index, a surrogate marker of insulin resistance (IR), is a prognostic risk factor in the general population. We aimed to assess whether it is an independent predictor of outcome also in patients with chronic coronary syndrome (CCS).
Methods and results
TyG index was evaluated in 1097 consecutive patients (75% men, median age 72 years) with known (26%) or suspected coronary artery disease (CAD), undergoing stress-rest myocardial perfusion scintigraphy, and coronary angiography and followed up for a median of 4.5 years. Moderate/severe perfusion abnormalities during stress (summed stress score >7) were documented in 60% of patients, obstructive CAD in 74%, and 36% underwent early revascularization. TyG index was 8.9 (median, interquartile interval 8.6–9.2). Cardiac death or myocardial infarction occurred in 103 patients and all-cause death in 65. After correction for clinical risk factors, LV function and common bio-humoral variables, TyG index (HR 2.42, 95% CI 1.57–3.72, P < 0.001), and moderate/severe stress perfusion abnormalities (hazard ratio (HR) 2.17, 95% confidence interval (CI) 1.25–3.77, P < 0.001) independently predicted cardiac events. TyG index (HR 3.64, 95%CI 2.22–5.96, P < 0.001) and high-sensitivity C-reactive protein (HR 1.11, 95% CI 1.04–1.19, P = 0.002) independently predicted all-cause death.
Conclusion
In patients with CCS, the TyG index identifies a cardiometabolic profile associated with an additional risk of cardiac events, over the presence of myocardial ischaemia and independently of other clinical, common bio-humoral or imaging risk determinants.
Graphical Abstract
Graphical AbstractPatients with chronic coronary symptoms were characterized by clinical variables, risk factors and common bio markers. They underwent diagnostic screening by functional and anatomical cardiac imaging and followed-up for 4.6 years. LDL cholesterol, obstructive coronary artery disease, moderate–severe myocardial ischaemia and the trygliceride-glucose index stratified the risk of cardiac events. The multivariable predictive model including trygliceride-glucose index and high-sensitivity C-reactive protein outperformed all other models.</abstract><pub>Oxford University Press</pub><pmid>35919094</pmid><doi>10.1093/ehjopen/oeab004</doi><orcidid>https://orcid.org/0000-0003-0016-9538</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Oxford Journals Open Access Collection; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Analysis Antilipemic agents Care and treatment Diagnosis Dosage and administration Glucose tolerance tests Health aspects Measurement Myocardial ischemia Original Triglycerides |
| title | Triglyceride-glucose index predicts outcome in patients with chronic coronary syndrome independently of other risk factors and myocardial ischaemia |
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