TNF-α Triggers RIP1/FADD/Caspase-8-Mediated Apoptosis of Astrocytes and RIP3/MLKL-Mediated Necroptosis of Neurons Induced by Angiostrongylus cantonensis Infection

Angiostrongylus cantonensis (AC) can cause severe eosinophilic meningitis or encephalitis in non-permissive hosts accompanied by apoptosis and necroptosis of brain cells. However, the explicit underlying molecular basis of apoptosis and necroptosis upon AC infection has not yet been elucidated. To d...

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Veröffentlicht in:	Cellular and molecular neurobiology 2022-08, Vol.42 (6), p.1841-1857
Hauptverfasser:	Zhou, Hongli, Zhou, Minyu, Hu, Yue, Limpanon, Yanin, Ma, Yubin, Huang, Ping, Dekumyoy, Paron, Maleewong, Wanchai, Lv, Zhiyue
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiostrongylus cantonensis Apoptosis Astrocytes Biomedical and Life Sciences Biomedicine Caspase-8 Cell Biology Cell death DNA microarrays Encephalitis FADD protein Gene expression Gene set enrichment analysis Immunoblotting Immunofluorescence Immunoprecipitation Infections Leukocytes (eosinophilic) Meningitis Microglia Necroptosis Neurobiology Neurons Neurosciences Original Research Signal transduction Tumor necrosis factor-α
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