Selectively Fluorinated Citronellol Analogues Support a Hydrogen Bonding Donor Interaction with the Human OR1A1 Olfactory Receptor

C-2 fluorinated and methylated stereoisomers of the fragrance citronellol 1 and its oxalate esters were prepared from (R)-pulegone 11 and explored as agonists of the human olfactory receptor OR1A1 and assayed also against site-specific mutants. There were clear isomer preferences and C-2 difluorinat...

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Veröffentlicht in:	Organic letters 2022-06, Vol.24 (24), p.4415-4420
Hauptverfasser:	He, Mengfan, Liu, Weihong, Zhang, Chen, Liu, Yingjian, Zhuang, Hanyi, O’Hagan, David
Format:	Artikel
Sprache:	eng
Schlagworte:	Letter
Online-Zugang:	Volltext
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