Higher CSF Ferritin Heavy-Chain (Fth1) and Transferrin Predict Better Neurocognitive Performance in People with HIV

HIV-associated neurocognitive disorder (HAND) remains prevalent despite antiretroviral therapy and involves white matter damage in the brain. Although iron is essential for myelination and myelin maintenance/repair, its role in HAND is largely unexplored. We tested the hypotheses that cerebrospinal...

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Veröffentlicht in:	Molecular neurobiology 2021-10, Vol.58 (10), p.4842-4855
Hauptverfasser:	Kaur, Harpreet, Bush, William S., Letendre, Scott L., Ellis, Ronald J., Heaton, Robert K., Patton, Stephanie M., Connor, James R., Samuels, David C., Franklin, Donald R., Hulgan, Todd, Kallianpur, Asha R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult AIDS Dementia Complex - cerebrospinal fluid AIDS Dementia Complex - diagnosis AIDS Dementia Complex - psychology Alzheimer's disease Antiretroviral drugs Antiretroviral therapy Bioavailability Biomarkers - cerebrospinal fluid Biomedical and Life Sciences Biomedicine Brain injury Brain research Cell Biology Cerebrospinal fluid Charters Cognition Comorbidity Drug therapy Female Ferritin Ferritins - cerebrospinal fluid HIV HIV Infections - cerebrospinal fluid HIV Infections - diagnosis HIV Infections - psychology Homeostasis Human immunodeficiency virus Humans Hypotheses Infections Inflammation Interleukin 6 Iron Longitudinal Studies Male Medicine Mental Status and Dementia Tests Metabolism Middle Aged Myelination Neurobiology Neurology Neuroprotection Neurosciences Oxidoreductases - cerebrospinal fluid Predictive Value of Tests Prospective Studies Proteins Psychiatry Substantia alba Transferrin - cerebrospinal fluid Transferrins Tumor necrosis factor-α Viremia
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