Identification and characterization of the anti-SARS-CoV-2 activity of cationic amphiphilic steroidal compounds

The ongoing COVID-19 pandemic caused a significant loss of human lives and a worldwide decline in quality of life. Treatment of COVID-19 patients is challenging, and specific treatments to reduce COVID-19 aggravation and mortality are still necessary. Here, we describe the discovery of a novel class...

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Veröffentlicht in:	Virulence 2022-12, Vol.13 (1), p.1031-1048
Hauptverfasser:	Borin, Alexandre, Coimbra, Laís D., Bispo-dos-Santos, Karina, Naciuk, Fabrício F., Fontoura, Marina, Simeoni, Camila L., Gomes, Giovanni F., Amorim, Mariene R., Gravina, Humberto D., Shimizu, Jacqueline Farinha, Passos, Amanda S. C., de Oliveira, Isadora M., de Carvalho, Ana Carolina, Cardoso, Alisson Campos, Parise, Pierina L., Toledo-Teixeira, Daniel A., Sotorilli, Giuliana E., Persinoti, Gabriela F., Claro, Ingra Morales, Sabino, Ester C., Alborghetti, Marcos R., Rocco, Silvana A., Franchini, Kleber G., de Souza, William M., Oliveira, Paulo S. L., Cunha, Thiago M., Granja, Fabiana, Proença-Módena, José Luiz, Trivella, Daniela B.B., Bruder, Marjorie, Cordeiro, Artur T., Marques, Rafael Elias
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals antiviral activity Antiviral Agents - pharmacology Chlorocebus aethiops COVID-19 Drug Treatment drug discovery HEK293 Cells Humans Lipids Mice Pandemics Quality of Life Research Paper SARS-CoV-2 steroidal compounds Vero Cells Virus Replication
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