Modeling Androgen Deprivation Therapy-Induced Prostate Cancer Dormancy and Its Clinical Implications

Treatment-induced tumor dormancy is a state in cancer progression where residual disease is present but remains asymptomatic. Dormant cancer cells are treatment-resistant and responsible for cancer recurrence and metastasis. Prostate cancer treated with androgen-deprivation therapy (ADT) often enter...

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Veröffentlicht in:	Molecular cancer research 2022-05, Vol.20 (5), p.782-793
Hauptverfasser:	Dong, Xin, Xue, Hui, Mo, Fan, Lin, Yen-Yi, Lin, Dong, Wong, Nelson K Y, Sun, Yingqiang, Wilkinson, Scott, Ku, Anson T, Hao, Jun, Ci, Xinpei, Wu, Rebecca, Haegert, Anne, Silver, Rebecca, Taplin, Mary-Ellen, Balk, Steven P, Alumkal, Joshi J, Sowalsky, Adam G, Gleave, Martin, Collins, Colin, Wang, Yuzhuo
Format:	Artikel
Sprache:	eng
Schlagworte:	Androgen Antagonists - pharmacology Androgen Receptor Antagonists Androgens - therapeutic use Animals Humans Male Mice Neoplasm Recurrence, Local Prostatic Neoplasms - drug therapy Prostatic Neoplasms - genetics Prostatic Neoplasms - metabolism Prostatic Neoplasms, Castration-Resistant - pathology
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