Serum Concentrations of Cartilage Intermediate Layer Protein 2 Were Higher in Overweight and Obese Subjects
Background. Cartilage intermediate layer protein 2 (CILP2) is associated with a variety of plasma lipoproteins and lipid traits. However, the correlation between CILP2 and obesity remains unknown. The aim of this study was to investigate the relationship between circulating CILP2 levels and obesity...
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| Veröffentlicht in: | BioMed research international 2022, Vol.2022 (1), p.6290064-6290064 |
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| description | Background. Cartilage intermediate layer protein 2 (CILP2) is associated with a variety of plasma lipoproteins and lipid traits. However, the correlation between CILP2 and obesity remains unknown. The aim of this study was to investigate the relationship between circulating CILP2 levels and obesity based on body mass index (BMI). Methods. A total of 252 subjects were divided into three groups: normal weight (n=124), overweight (n=94), and obese (n=34). Metabolic parameters were measured in a fasting state. Serum CILP2 concentration was tested by enzyme-linked immunosorbent assay. Multivariate linear regression analysis was used to explore the relationship between CILP2 and obesity. We also conducted bioinformatics analysis to further explore the genes and signaling pathways related to CILP2. Results. The concentrations of serum CILP2 in the overweight and obese groups were significantly higher than that in the normal weight group. In multiple linear regression analysis, BMI was positively correlated with CILP2 concentration after controlling gender and age. Being overweight and obese were independently correlated with CILP2 concentration after adjusting for gender, age, SBP, DBP, FBG, 2-hour OGTT blood glucose (2h-BG), fasting blood insulin (FIns), TG, TC, HDL-C, LDL-C, and FFA. Bioinformatics analysis showed that the genes related to CILP2 are primarily associated with lipid metabolism and insulin resistance. Conclusion. We speculate that CILP2 may attribute to metabolic disorders in obesity. |
| doi_str_mv | 10.1155/2022/6290064 |
| format | Article |
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Cartilage intermediate layer protein 2 (CILP2) is associated with a variety of plasma lipoproteins and lipid traits. However, the correlation between CILP2 and obesity remains unknown. The aim of this study was to investigate the relationship between circulating CILP2 levels and obesity based on body mass index (BMI). Methods. A total of 252 subjects were divided into three groups: normal weight (n=124), overweight (n=94), and obese (n=34). Metabolic parameters were measured in a fasting state. Serum CILP2 concentration was tested by enzyme-linked immunosorbent assay. Multivariate linear regression analysis was used to explore the relationship between CILP2 and obesity. We also conducted bioinformatics analysis to further explore the genes and signaling pathways related to CILP2. Results. The concentrations of serum CILP2 in the overweight and obese groups were significantly higher than that in the normal weight group. In multiple linear regression analysis, BMI was positively correlated with CILP2 concentration after controlling gender and age. Being overweight and obese were independently correlated with CILP2 concentration after adjusting for gender, age, SBP, DBP, FBG, 2-hour OGTT blood glucose (2h-BG), fasting blood insulin (FIns), TG, TC, HDL-C, LDL-C, and FFA. Bioinformatics analysis showed that the genes related to CILP2 are primarily associated with lipid metabolism and insulin resistance. Conclusion. We speculate that CILP2 may attribute to metabolic disorders in obesity.</description><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2022/6290064</identifier><identifier>PMID: 35757483</identifier><language>eng</language><publisher>New York: Hindawi</publisher><subject>Bioinformatics ; Blood ; Blood glucose ; Body fat ; Body mass ; Body mass index ; Body size ; Body weight ; Cartilage ; Enzyme-linked immunosorbent assay ; Fasting ; Fins ; Gender ; Genes ; High density lipoprotein ; Insulin ; Insulin resistance ; Lipid metabolism ; Lipids ; Lipoproteins ; Low density lipoprotein ; Metabolic disorders ; Obesity ; Overweight ; Proteins ; Regression analysis</subject><ispartof>BioMed research international, 2022, Vol.2022 (1), p.6290064-6290064</ispartof><rights>Copyright © 2022 Qinge Li et al.</rights><rights>Copyright © 2022 Qinge Li et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2022 Qinge Li et al. 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c382t-c185ec6b12634a2e936a283183ad2d33686420ad761be13bb62676fdf53f8c363</cites><orcidid>0000-0002-0087-3034</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9225864/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9225864/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,4010,27900,27901,27902,53766,53768</link.rule.ids></links><search><contributor>Valacchi, Giuseppe</contributor><contributor>Giuseppe Valacchi</contributor><creatorcontrib>Li, Qinge</creatorcontrib><creatorcontrib>Pu, Danlan</creatorcontrib><creatorcontrib>Xia, Xuyun</creatorcontrib><creatorcontrib>Liu, Hua</creatorcontrib><creatorcontrib>Li, Ling</creatorcontrib><title>Serum Concentrations of Cartilage Intermediate Layer Protein 2 Were Higher in Overweight and Obese Subjects</title><title>BioMed research international</title><description>Background. Cartilage intermediate layer protein 2 (CILP2) is associated with a variety of plasma lipoproteins and lipid traits. However, the correlation between CILP2 and obesity remains unknown. The aim of this study was to investigate the relationship between circulating CILP2 levels and obesity based on body mass index (BMI). Methods. A total of 252 subjects were divided into three groups: normal weight (n=124), overweight (n=94), and obese (n=34). Metabolic parameters were measured in a fasting state. Serum CILP2 concentration was tested by enzyme-linked immunosorbent assay. Multivariate linear regression analysis was used to explore the relationship between CILP2 and obesity. We also conducted bioinformatics analysis to further explore the genes and signaling pathways related to CILP2. Results. The concentrations of serum CILP2 in the overweight and obese groups were significantly higher than that in the normal weight group. In multiple linear regression analysis, BMI was positively correlated with CILP2 concentration after controlling gender and age. Being overweight and obese were independently correlated with CILP2 concentration after adjusting for gender, age, SBP, DBP, FBG, 2-hour OGTT blood glucose (2h-BG), fasting blood insulin (FIns), TG, TC, HDL-C, LDL-C, and FFA. Bioinformatics analysis showed that the genes related to CILP2 are primarily associated with lipid metabolism and insulin resistance. Conclusion. We speculate that CILP2 may attribute to metabolic disorders in obesity.</description><subject>Bioinformatics</subject><subject>Blood</subject><subject>Blood glucose</subject><subject>Body fat</subject><subject>Body mass</subject><subject>Body mass index</subject><subject>Body size</subject><subject>Body weight</subject><subject>Cartilage</subject><subject>Enzyme-linked immunosorbent assay</subject><subject>Fasting</subject><subject>Fins</subject><subject>Gender</subject><subject>Genes</subject><subject>High density lipoprotein</subject><subject>Insulin</subject><subject>Insulin resistance</subject><subject>Lipid metabolism</subject><subject>Lipids</subject><subject>Lipoproteins</subject><subject>Low density lipoprotein</subject><subject>Metabolic disorders</subject><subject>Obesity</subject><subject>Overweight</subject><subject>Proteins</subject><subject>Regression 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Concentrations of Cartilage Intermediate Layer Protein 2 Were Higher in Overweight and Obese Subjects</title><author>Li, Qinge ; Pu, Danlan ; Xia, Xuyun ; Liu, Hua ; Li, Ling</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c382t-c185ec6b12634a2e936a283183ad2d33686420ad761be13bb62676fdf53f8c363</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Bioinformatics</topic><topic>Blood</topic><topic>Blood glucose</topic><topic>Body fat</topic><topic>Body mass</topic><topic>Body mass index</topic><topic>Body size</topic><topic>Body weight</topic><topic>Cartilage</topic><topic>Enzyme-linked immunosorbent assay</topic><topic>Fasting</topic><topic>Fins</topic><topic>Gender</topic><topic>Genes</topic><topic>High density lipoprotein</topic><topic>Insulin</topic><topic>Insulin resistance</topic><topic>Lipid metabolism</topic><topic>Lipids</topic><topic>Lipoproteins</topic><topic>Low density lipoprotein</topic><topic>Metabolic disorders</topic><topic>Obesity</topic><topic>Overweight</topic><topic>Proteins</topic><topic>Regression analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Qinge</creatorcontrib><creatorcontrib>Pu, Danlan</creatorcontrib><creatorcontrib>Xia, Xuyun</creatorcontrib><creatorcontrib>Liu, Hua</creatorcontrib><creatorcontrib>Li, Ling</creatorcontrib><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology 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Valacchi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum Concentrations of Cartilage Intermediate Layer Protein 2 Were Higher in Overweight and Obese Subjects</atitle><jtitle>BioMed research international</jtitle><date>2022</date><risdate>2022</risdate><volume>2022</volume><issue>1</issue><spage>6290064</spage><epage>6290064</epage><pages>6290064-6290064</pages><issn>2314-6133</issn><eissn>2314-6141</eissn><abstract>Background. Cartilage intermediate layer protein 2 (CILP2) is associated with a variety of plasma lipoproteins and lipid traits. However, the correlation between CILP2 and obesity remains unknown. The aim of this study was to investigate the relationship between circulating CILP2 levels and obesity based on body mass index (BMI). Methods. A total of 252 subjects were divided into three groups: normal weight (n=124), overweight (n=94), and obese (n=34). Metabolic parameters were measured in a fasting state. Serum CILP2 concentration was tested by enzyme-linked immunosorbent assay. Multivariate linear regression analysis was used to explore the relationship between CILP2 and obesity. We also conducted bioinformatics analysis to further explore the genes and signaling pathways related to CILP2. Results. The concentrations of serum CILP2 in the overweight and obese groups were significantly higher than that in the normal weight group. In multiple linear regression analysis, BMI was positively correlated with CILP2 concentration after controlling gender and age. Being overweight and obese were independently correlated with CILP2 concentration after adjusting for gender, age, SBP, DBP, FBG, 2-hour OGTT blood glucose (2h-BG), fasting blood insulin (FIns), TG, TC, HDL-C, LDL-C, and FFA. Bioinformatics analysis showed that the genes related to CILP2 are primarily associated with lipid metabolism and insulin resistance. Conclusion. We speculate that CILP2 may attribute to metabolic disorders in obesity.</abstract><cop>New York</cop><pub>Hindawi</pub><pmid>35757483</pmid><doi>10.1155/2022/6290064</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-0087-3034</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Bioinformatics Blood Blood glucose Body fat Body mass Body mass index Body size Body weight Cartilage Enzyme-linked immunosorbent assay Fasting Fins Gender Genes High density lipoprotein Insulin Insulin resistance Lipid metabolism Lipids Lipoproteins Low density lipoprotein Metabolic disorders Obesity Overweight Proteins Regression analysis |
| title | Serum Concentrations of Cartilage Intermediate Layer Protein 2 Were Higher in Overweight and Obese Subjects |
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