Differential Immune Checkpoint and Ig-like V-Type Receptor Profiles in COVID-19: Associations with Severity and Treatment
Identifying patients' immune system status has become critical to managing SARS-CoV-2 infection and avoiding the appearance of secondary infections during a hospital stay. Despite the high volume of research, robust severity and outcome markers are still lacking in COVID-19. We recruited 87 COV...
Gespeichert in:
| Veröffentlicht in: | Journal of clinical medicine 2022-06, Vol.11 (12), p.3287 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 12 |
| container_start_page | 3287 |
| container_title | Journal of clinical medicine |
| container_volume | 11 |
| creator | Lozano-Rodríguez, Roberto Terrón-Arcos, Verónica López, Raúl Martín-Gutiérrez, Juan Martín-Quirós, Alejandro Maroun-Eid, Charbel Del Val, Elena Muñoz Cañada-Illana, Carlos Pascual Iglesias, Alejandro Quiroga, Jaime Valentín Montalbán-Hernández, Karla Casalvilla-Dueñas, José Carlos García-Garrido, Miguel A Del Balzo-Castillo, Álvaro Peinado-Quesada, María A Gómez-Lage, Laura Herrero-Benito, Carmen G Butler, Ray Avendaño-Ortiz, José López-Collazo, Eduardo |
| description | Identifying patients' immune system status has become critical to managing SARS-CoV-2 infection and avoiding the appearance of secondary infections during a hospital stay. Despite the high volume of research, robust severity and outcome markers are still lacking in COVID-19. We recruited 87 COVID-19 patients and analyzed, by unbiased automated software, 356 parameters at baseline emergency department admission including: high depth immune phenotyping and immune checkpoint expression by spectral flow cytometry, cytokines and other soluble molecules in plasma as well as routine clinical variables. We identified 69 baseline alterations in the expression of immune checkpoints, Ig-like V type receptors and other immune population markers associated with severity (O
requirement). Thirty-four changes in these markers/populations were associated with secondary infection appearance. In addition, through a longitudinal sample collection, we described the changes which take place in the immune system of COVID-19 patients during secondary infections and in response to corticosteroid treatment. Our study provides information about immune checkpoint molecules and other less-studied receptors with Ig-like V-type domains such as CD108, CD226, HVEM (CD270), B7H3 (CD276), B7H5 (VISTA) and GITR (CD357), defining these as novel interesting molecules in severe and corticosteroids-treated acute infections. |
| doi_str_mv | 10.3390/jcm11123287 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9225268</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2679744662</sourcerecordid><originalsourceid>FETCH-LOGICAL-c409t-1ee70f261714071fbda073634f7cb4feb394e604ff33cbea4a41792c98f8406c3</originalsourceid><addsrcrecordid>eNpdkd1rFDEUxYMottQ--S4BXwQZzddOJj4IZevHQqGia19DJnvTzXYmGZNMZf97o61l9b7cC_fHuedyEHpOyRvOFXm7syOllHHWyUfomBEpG8I7_vhgPkKnOe9Ira4TjMqn6IgvpOB80R6j_bl3DhKE4s2AV-M4B8DLLdibKfpQsAkbvLpuBn8D-KpZ7yfAX8HCVGLCX1J0foCMfcDLy6vVeUPVO3yWc7TeFB9Dxj992eJvcAvJl_0fsXUCU8Z67xl64syQ4fS-n6DvHz-sl5-bi8tPq-XZRWMFUaWhAJI41lJJBZHU9RtDJG-5cNL2wkHPlYCWCOc4tz0YYQSVilnVuU6Q1vIT9P5Od5r7ETa2nk5m0FPyo0l7HY3X_26C3-rreKsVYwvWdlXg1b1Aij9myEWPPlsYBhMgzllXhhLBFkRV9OV_6C7OKdT3KiWVFKJtWaVe31E2xZwTuAczlOjfqeqDVCv94tD_A_s3Q_4LiYedXA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2679744662</pqid></control><display><type>article</type><title>Differential Immune Checkpoint and Ig-like V-Type Receptor Profiles in COVID-19: Associations with Severity and Treatment</title><source>MDPI - Multidisciplinary Digital Publishing Institute</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>PubMed Central Open Access</source><creator>Lozano-Rodríguez, Roberto ; Terrón-Arcos, Verónica ; López, Raúl ; Martín-Gutiérrez, Juan ; Martín-Quirós, Alejandro ; Maroun-Eid, Charbel ; Del Val, Elena Muñoz ; Cañada-Illana, Carlos ; Pascual Iglesias, Alejandro ; Quiroga, Jaime Valentín ; Montalbán-Hernández, Karla ; Casalvilla-Dueñas, José Carlos ; García-Garrido, Miguel A ; Del Balzo-Castillo, Álvaro ; Peinado-Quesada, María A ; Gómez-Lage, Laura ; Herrero-Benito, Carmen ; G Butler, Ray ; Avendaño-Ortiz, José ; López-Collazo, Eduardo</creator><creatorcontrib>Lozano-Rodríguez, Roberto ; Terrón-Arcos, Verónica ; López, Raúl ; Martín-Gutiérrez, Juan ; Martín-Quirós, Alejandro ; Maroun-Eid, Charbel ; Del Val, Elena Muñoz ; Cañada-Illana, Carlos ; Pascual Iglesias, Alejandro ; Quiroga, Jaime Valentín ; Montalbán-Hernández, Karla ; Casalvilla-Dueñas, José Carlos ; García-Garrido, Miguel A ; Del Balzo-Castillo, Álvaro ; Peinado-Quesada, María A ; Gómez-Lage, Laura ; Herrero-Benito, Carmen ; G Butler, Ray ; Avendaño-Ortiz, José ; López-Collazo, Eduardo</creatorcontrib><description>Identifying patients' immune system status has become critical to managing SARS-CoV-2 infection and avoiding the appearance of secondary infections during a hospital stay. Despite the high volume of research, robust severity and outcome markers are still lacking in COVID-19. We recruited 87 COVID-19 patients and analyzed, by unbiased automated software, 356 parameters at baseline emergency department admission including: high depth immune phenotyping and immune checkpoint expression by spectral flow cytometry, cytokines and other soluble molecules in plasma as well as routine clinical variables. We identified 69 baseline alterations in the expression of immune checkpoints, Ig-like V type receptors and other immune population markers associated with severity (O
requirement). Thirty-four changes in these markers/populations were associated with secondary infection appearance. In addition, through a longitudinal sample collection, we described the changes which take place in the immune system of COVID-19 patients during secondary infections and in response to corticosteroid treatment. Our study provides information about immune checkpoint molecules and other less-studied receptors with Ig-like V-type domains such as CD108, CD226, HVEM (CD270), B7H3 (CD276), B7H5 (VISTA) and GITR (CD357), defining these as novel interesting molecules in severe and corticosteroids-treated acute infections.</description><identifier>ISSN: 2077-0383</identifier><identifier>EISSN: 2077-0383</identifier><identifier>DOI: 10.3390/jcm11123287</identifier><identifier>PMID: 35743356</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Bacterial infections ; Chemokines ; Clinical medicine ; Coronaviruses ; COVID-19 ; Cytokines ; Immune system ; Immunology ; Infections ; Ligands ; Monoclonal antibodies ; Normal distribution ; Pandemics ; Patients ; Plasma ; Sample size ; Severe acute respiratory syndrome coronavirus 2 ; Software ; Steroids ; Thrombosis</subject><ispartof>Journal of clinical medicine, 2022-06, Vol.11 (12), p.3287</ispartof><rights>2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2022 by the authors. 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c409t-1ee70f261714071fbda073634f7cb4feb394e604ff33cbea4a41792c98f8406c3</citedby><cites>FETCH-LOGICAL-c409t-1ee70f261714071fbda073634f7cb4feb394e604ff33cbea4a41792c98f8406c3</cites><orcidid>0000-0002-2214-5441 ; 0000-0002-1612-103X ; 0000-0002-2847-3673 ; 0000-0001-6460-0708 ; 0000-0003-0093-9707</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9225268/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9225268/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35743356$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lozano-Rodríguez, Roberto</creatorcontrib><creatorcontrib>Terrón-Arcos, Verónica</creatorcontrib><creatorcontrib>López, Raúl</creatorcontrib><creatorcontrib>Martín-Gutiérrez, Juan</creatorcontrib><creatorcontrib>Martín-Quirós, Alejandro</creatorcontrib><creatorcontrib>Maroun-Eid, Charbel</creatorcontrib><creatorcontrib>Del Val, Elena Muñoz</creatorcontrib><creatorcontrib>Cañada-Illana, Carlos</creatorcontrib><creatorcontrib>Pascual Iglesias, Alejandro</creatorcontrib><creatorcontrib>Quiroga, Jaime Valentín</creatorcontrib><creatorcontrib>Montalbán-Hernández, Karla</creatorcontrib><creatorcontrib>Casalvilla-Dueñas, José Carlos</creatorcontrib><creatorcontrib>García-Garrido, Miguel A</creatorcontrib><creatorcontrib>Del Balzo-Castillo, Álvaro</creatorcontrib><creatorcontrib>Peinado-Quesada, María A</creatorcontrib><creatorcontrib>Gómez-Lage, Laura</creatorcontrib><creatorcontrib>Herrero-Benito, Carmen</creatorcontrib><creatorcontrib>G Butler, Ray</creatorcontrib><creatorcontrib>Avendaño-Ortiz, José</creatorcontrib><creatorcontrib>López-Collazo, Eduardo</creatorcontrib><title>Differential Immune Checkpoint and Ig-like V-Type Receptor Profiles in COVID-19: Associations with Severity and Treatment</title><title>Journal of clinical medicine</title><addtitle>J Clin Med</addtitle><description>Identifying patients' immune system status has become critical to managing SARS-CoV-2 infection and avoiding the appearance of secondary infections during a hospital stay. Despite the high volume of research, robust severity and outcome markers are still lacking in COVID-19. We recruited 87 COVID-19 patients and analyzed, by unbiased automated software, 356 parameters at baseline emergency department admission including: high depth immune phenotyping and immune checkpoint expression by spectral flow cytometry, cytokines and other soluble molecules in plasma as well as routine clinical variables. We identified 69 baseline alterations in the expression of immune checkpoints, Ig-like V type receptors and other immune population markers associated with severity (O
requirement). Thirty-four changes in these markers/populations were associated with secondary infection appearance. In addition, through a longitudinal sample collection, we described the changes which take place in the immune system of COVID-19 patients during secondary infections and in response to corticosteroid treatment. Our study provides information about immune checkpoint molecules and other less-studied receptors with Ig-like V-type domains such as CD108, CD226, HVEM (CD270), B7H3 (CD276), B7H5 (VISTA) and GITR (CD357), defining these as novel interesting molecules in severe and corticosteroids-treated acute infections.</description><subject>Bacterial infections</subject><subject>Chemokines</subject><subject>Clinical medicine</subject><subject>Coronaviruses</subject><subject>COVID-19</subject><subject>Cytokines</subject><subject>Immune system</subject><subject>Immunology</subject><subject>Infections</subject><subject>Ligands</subject><subject>Monoclonal antibodies</subject><subject>Normal distribution</subject><subject>Pandemics</subject><subject>Patients</subject><subject>Plasma</subject><subject>Sample size</subject><subject>Severe acute respiratory syndrome coronavirus 2</subject><subject>Software</subject><subject>Steroids</subject><subject>Thrombosis</subject><issn>2077-0383</issn><issn>2077-0383</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNpdkd1rFDEUxYMottQ--S4BXwQZzddOJj4IZevHQqGia19DJnvTzXYmGZNMZf97o61l9b7cC_fHuedyEHpOyRvOFXm7syOllHHWyUfomBEpG8I7_vhgPkKnOe9Ira4TjMqn6IgvpOB80R6j_bl3DhKE4s2AV-M4B8DLLdibKfpQsAkbvLpuBn8D-KpZ7yfAX8HCVGLCX1J0foCMfcDLy6vVeUPVO3yWc7TeFB9Dxj992eJvcAvJl_0fsXUCU8Z67xl64syQ4fS-n6DvHz-sl5-bi8tPq-XZRWMFUaWhAJI41lJJBZHU9RtDJG-5cNL2wkHPlYCWCOc4tz0YYQSVilnVuU6Q1vIT9P5Od5r7ETa2nk5m0FPyo0l7HY3X_26C3-rreKsVYwvWdlXg1b1Aij9myEWPPlsYBhMgzllXhhLBFkRV9OV_6C7OKdT3KiWVFKJtWaVe31E2xZwTuAczlOjfqeqDVCv94tD_A_s3Q_4LiYedXA</recordid><startdate>20220608</startdate><enddate>20220608</enddate><creator>Lozano-Rodríguez, Roberto</creator><creator>Terrón-Arcos, Verónica</creator><creator>López, Raúl</creator><creator>Martín-Gutiérrez, Juan</creator><creator>Martín-Quirós, Alejandro</creator><creator>Maroun-Eid, Charbel</creator><creator>Del Val, Elena Muñoz</creator><creator>Cañada-Illana, Carlos</creator><creator>Pascual Iglesias, Alejandro</creator><creator>Quiroga, Jaime Valentín</creator><creator>Montalbán-Hernández, Karla</creator><creator>Casalvilla-Dueñas, José Carlos</creator><creator>García-Garrido, Miguel A</creator><creator>Del Balzo-Castillo, Álvaro</creator><creator>Peinado-Quesada, María A</creator><creator>Gómez-Lage, Laura</creator><creator>Herrero-Benito, Carmen</creator><creator>G Butler, Ray</creator><creator>Avendaño-Ortiz, José</creator><creator>López-Collazo, Eduardo</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>COVID</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-2214-5441</orcidid><orcidid>https://orcid.org/0000-0002-1612-103X</orcidid><orcidid>https://orcid.org/0000-0002-2847-3673</orcidid><orcidid>https://orcid.org/0000-0001-6460-0708</orcidid><orcidid>https://orcid.org/0000-0003-0093-9707</orcidid></search><sort><creationdate>20220608</creationdate><title>Differential Immune Checkpoint and Ig-like V-Type Receptor Profiles in COVID-19: Associations with Severity and Treatment</title><author>Lozano-Rodríguez, Roberto ; Terrón-Arcos, Verónica ; López, Raúl ; Martín-Gutiérrez, Juan ; Martín-Quirós, Alejandro ; Maroun-Eid, Charbel ; Del Val, Elena Muñoz ; Cañada-Illana, Carlos ; Pascual Iglesias, Alejandro ; Quiroga, Jaime Valentín ; Montalbán-Hernández, Karla ; Casalvilla-Dueñas, José Carlos ; García-Garrido, Miguel A ; Del Balzo-Castillo, Álvaro ; Peinado-Quesada, María A ; Gómez-Lage, Laura ; Herrero-Benito, Carmen ; G Butler, Ray ; Avendaño-Ortiz, José ; López-Collazo, Eduardo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c409t-1ee70f261714071fbda073634f7cb4feb394e604ff33cbea4a41792c98f8406c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Bacterial infections</topic><topic>Chemokines</topic><topic>Clinical medicine</topic><topic>Coronaviruses</topic><topic>COVID-19</topic><topic>Cytokines</topic><topic>Immune system</topic><topic>Immunology</topic><topic>Infections</topic><topic>Ligands</topic><topic>Monoclonal antibodies</topic><topic>Normal distribution</topic><topic>Pandemics</topic><topic>Patients</topic><topic>Plasma</topic><topic>Sample size</topic><topic>Severe acute respiratory syndrome coronavirus 2</topic><topic>Software</topic><topic>Steroids</topic><topic>Thrombosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lozano-Rodríguez, Roberto</creatorcontrib><creatorcontrib>Terrón-Arcos, Verónica</creatorcontrib><creatorcontrib>López, Raúl</creatorcontrib><creatorcontrib>Martín-Gutiérrez, Juan</creatorcontrib><creatorcontrib>Martín-Quirós, Alejandro</creatorcontrib><creatorcontrib>Maroun-Eid, Charbel</creatorcontrib><creatorcontrib>Del Val, Elena Muñoz</creatorcontrib><creatorcontrib>Cañada-Illana, Carlos</creatorcontrib><creatorcontrib>Pascual Iglesias, Alejandro</creatorcontrib><creatorcontrib>Quiroga, Jaime Valentín</creatorcontrib><creatorcontrib>Montalbán-Hernández, Karla</creatorcontrib><creatorcontrib>Casalvilla-Dueñas, José Carlos</creatorcontrib><creatorcontrib>García-Garrido, Miguel A</creatorcontrib><creatorcontrib>Del Balzo-Castillo, Álvaro</creatorcontrib><creatorcontrib>Peinado-Quesada, María A</creatorcontrib><creatorcontrib>Gómez-Lage, Laura</creatorcontrib><creatorcontrib>Herrero-Benito, Carmen</creatorcontrib><creatorcontrib>G Butler, Ray</creatorcontrib><creatorcontrib>Avendaño-Ortiz, José</creatorcontrib><creatorcontrib>López-Collazo, Eduardo</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Coronavirus Research Database</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of clinical medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lozano-Rodríguez, Roberto</au><au>Terrón-Arcos, Verónica</au><au>López, Raúl</au><au>Martín-Gutiérrez, Juan</au><au>Martín-Quirós, Alejandro</au><au>Maroun-Eid, Charbel</au><au>Del Val, Elena Muñoz</au><au>Cañada-Illana, Carlos</au><au>Pascual Iglesias, Alejandro</au><au>Quiroga, Jaime Valentín</au><au>Montalbán-Hernández, Karla</au><au>Casalvilla-Dueñas, José Carlos</au><au>García-Garrido, Miguel A</au><au>Del Balzo-Castillo, Álvaro</au><au>Peinado-Quesada, María A</au><au>Gómez-Lage, Laura</au><au>Herrero-Benito, Carmen</au><au>G Butler, Ray</au><au>Avendaño-Ortiz, José</au><au>López-Collazo, Eduardo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Differential Immune Checkpoint and Ig-like V-Type Receptor Profiles in COVID-19: Associations with Severity and Treatment</atitle><jtitle>Journal of clinical medicine</jtitle><addtitle>J Clin Med</addtitle><date>2022-06-08</date><risdate>2022</risdate><volume>11</volume><issue>12</issue><spage>3287</spage><pages>3287-</pages><issn>2077-0383</issn><eissn>2077-0383</eissn><abstract>Identifying patients' immune system status has become critical to managing SARS-CoV-2 infection and avoiding the appearance of secondary infections during a hospital stay. Despite the high volume of research, robust severity and outcome markers are still lacking in COVID-19. We recruited 87 COVID-19 patients and analyzed, by unbiased automated software, 356 parameters at baseline emergency department admission including: high depth immune phenotyping and immune checkpoint expression by spectral flow cytometry, cytokines and other soluble molecules in plasma as well as routine clinical variables. We identified 69 baseline alterations in the expression of immune checkpoints, Ig-like V type receptors and other immune population markers associated with severity (O
requirement). Thirty-four changes in these markers/populations were associated with secondary infection appearance. In addition, through a longitudinal sample collection, we described the changes which take place in the immune system of COVID-19 patients during secondary infections and in response to corticosteroid treatment. Our study provides information about immune checkpoint molecules and other less-studied receptors with Ig-like V-type domains such as CD108, CD226, HVEM (CD270), B7H3 (CD276), B7H5 (VISTA) and GITR (CD357), defining these as novel interesting molecules in severe and corticosteroids-treated acute infections.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>35743356</pmid><doi>10.3390/jcm11123287</doi><orcidid>https://orcid.org/0000-0002-2214-5441</orcidid><orcidid>https://orcid.org/0000-0002-1612-103X</orcidid><orcidid>https://orcid.org/0000-0002-2847-3673</orcidid><orcidid>https://orcid.org/0000-0001-6460-0708</orcidid><orcidid>https://orcid.org/0000-0003-0093-9707</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2077-0383 |
| ispartof | Journal of clinical medicine, 2022-06, Vol.11 (12), p.3287 |
| issn | 2077-0383 2077-0383 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9225268 |
| source | MDPI - Multidisciplinary Digital Publishing Institute; EZB-FREE-00999 freely available EZB journals; PubMed Central; PubMed Central Open Access |
| subjects | Bacterial infections Chemokines Clinical medicine Coronaviruses COVID-19 Cytokines Immune system Immunology Infections Ligands Monoclonal antibodies Normal distribution Pandemics Patients Plasma Sample size Severe acute respiratory syndrome coronavirus 2 Software Steroids Thrombosis |
| title | Differential Immune Checkpoint and Ig-like V-Type Receptor Profiles in COVID-19: Associations with Severity and Treatment |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-01T14%3A54%3A39IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Differential%20Immune%20Checkpoint%20and%20Ig-like%20V-Type%20Receptor%20Profiles%20in%20COVID-19:%20Associations%20with%20Severity%20and%20Treatment&rft.jtitle=Journal%20of%20clinical%20medicine&rft.au=Lozano-Rodr%C3%ADguez,%20Roberto&rft.date=2022-06-08&rft.volume=11&rft.issue=12&rft.spage=3287&rft.pages=3287-&rft.issn=2077-0383&rft.eissn=2077-0383&rft_id=info:doi/10.3390/jcm11123287&rft_dat=%3Cproquest_pubme%3E2679744662%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2679744662&rft_id=info:pmid/35743356&rfr_iscdi=true |