Long-Term Pregnancy Outcomes of Patients with Diffuse Adenomyosis after Double-Flap Adenomyomectomy
Although many studies show that patients with diffuse adenomyosis who underwent fertility-sparing surgery can have a successful pregnancy, their pregnancy outcomes are still controversial. The objective of this study was to determine long-term pregnancy outcomes and possible influencing factors afte...
Gespeichert in:
| Veröffentlicht in: | Journal of clinical medicine 2022-06, Vol.11 (12), p.3489 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 12 |
| container_start_page | 3489 |
| container_title | Journal of clinical medicine |
| container_volume | 11 |
| creator | Zhou, Yong Shen, Li Wang, Yuan Yang, Mengjia Chen, Zhengyun Zhang, Xinmei |
| description | Although many studies show that patients with diffuse adenomyosis who underwent fertility-sparing surgery can have a successful pregnancy, their pregnancy outcomes are still controversial. The objective of this study was to determine long-term pregnancy outcomes and possible influencing factors after double-flap adenomyomectomy for patients with diffuse adenomyosis. A total of 137 patients with diffuse adenomyosis who underwent double-flap adenomyomectomy between January 2011 and December 2019 were studied, and correlations between pregnancy outcomes and clinical data, including age and junctional zone measured by magnetic resonance imaging (JZmax-A), were analyzed. The results show that 56 patients (40.9%, 56/137) had 62 pregnancies, including 35 natural pregnancies and 27 assisted reproduction pregnancies, after operation. A univariate regression analysis showed that the pregnancy outcomes were related to age at surgery, visual analog scale (VAS) score of preoperative dysmenorrhea, parity experience, length of infertility, and postoperative JZmax-A. A multivariate regression analysis showed that age at surgery, VAS score of preoperative dysmenorrhea, and postoperative JZmax-A were the independent indicators correlated with pregnancy outcomes. A receiver operating characteristic curve analysis showed that postoperative JZmax-A was the most valuable indicator for predicting pregnancy outcomes. Cumulative pregnancy rates during the first 3 years were 70.1% and 20.9% in the postoperative JZmax-A ≤ 8.5 mm and the postoperative JZmax-A > 8.5 mm groups, respectively. In conclusion, double-flap adenomyomectomy could improve fertility for diffuse adenomyosis, and postoperative JZmax-A might be a promising indicator for predicting pregnancy outcomes. |
| doi_str_mv | 10.3390/jcm11123489 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9224895</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2679744661</sourcerecordid><originalsourceid>FETCH-LOGICAL-c409t-bcdbbea8339cb04390f93d3c27e70a950c7312b7ca9ab1cf5ab80fedd3c514053</originalsourceid><addsrcrecordid>eNpdkc1LAzEQxYMoKurJuwS8CLKabLLN5iJI_YRCe9BzSLKTumV3U5Ndpf-9KWqp5jKB-fF4bx5Cp5RcMSbJ9cK2lNKc8VLuoMOcCJERVrLdrf8BOolxQdIrS55TsY8OWCE4Kwp5iOzEd_PsBUKLZwHmne7sCk-H3voWIvYOz3RfQ9dH_Fn3b_iudm6IgG8r6Hy78rGOWLseAr7zg2kge2j0crNtwfZpHqM9p5sIJz_zCL0-3L-Mn7LJ9PF5fDvJLCeyz4ytjAFdplzWEJ7SOckqZnMBgmhZECsYzY2wWmpDrSu0KYmDKiEF5aRgR-jmW3c5mBYqm2wH3ahlqFsdVsrrWv3ddPWbmvsPJfM83W8tcPEjEPz7ALFXbR0tNI3uwA9R5aOSEr4-dkLP_6ELP4QuxUuUkILz0Ygm6vKbssHHGMBtzFCi1v2prf4Sfbbtf8P-tsW-AM6Ml9M</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2679744661</pqid></control><display><type>article</type><title>Long-Term Pregnancy Outcomes of Patients with Diffuse Adenomyosis after Double-Flap Adenomyomectomy</title><source>MDPI - Multidisciplinary Digital Publishing Institute</source><source>PubMed Central(OpenAccess)</source><source>EZB*</source><source>PubMed Central Open Access</source><creator>Zhou, Yong ; Shen, Li ; Wang, Yuan ; Yang, Mengjia ; Chen, Zhengyun ; Zhang, Xinmei</creator><creatorcontrib>Zhou, Yong ; Shen, Li ; Wang, Yuan ; Yang, Mengjia ; Chen, Zhengyun ; Zhang, Xinmei</creatorcontrib><description>Although many studies show that patients with diffuse adenomyosis who underwent fertility-sparing surgery can have a successful pregnancy, their pregnancy outcomes are still controversial. The objective of this study was to determine long-term pregnancy outcomes and possible influencing factors after double-flap adenomyomectomy for patients with diffuse adenomyosis. A total of 137 patients with diffuse adenomyosis who underwent double-flap adenomyomectomy between January 2011 and December 2019 were studied, and correlations between pregnancy outcomes and clinical data, including age and junctional zone measured by magnetic resonance imaging (JZmax-A), were analyzed. The results show that 56 patients (40.9%, 56/137) had 62 pregnancies, including 35 natural pregnancies and 27 assisted reproduction pregnancies, after operation. A univariate regression analysis showed that the pregnancy outcomes were related to age at surgery, visual analog scale (VAS) score of preoperative dysmenorrhea, parity experience, length of infertility, and postoperative JZmax-A. A multivariate regression analysis showed that age at surgery, VAS score of preoperative dysmenorrhea, and postoperative JZmax-A were the independent indicators correlated with pregnancy outcomes. A receiver operating characteristic curve analysis showed that postoperative JZmax-A was the most valuable indicator for predicting pregnancy outcomes. Cumulative pregnancy rates during the first 3 years were 70.1% and 20.9% in the postoperative JZmax-A ≤ 8.5 mm and the postoperative JZmax-A > 8.5 mm groups, respectively. In conclusion, double-flap adenomyomectomy could improve fertility for diffuse adenomyosis, and postoperative JZmax-A might be a promising indicator for predicting pregnancy outcomes.</description><identifier>ISSN: 2077-0383</identifier><identifier>EISSN: 2077-0383</identifier><identifier>DOI: 10.3390/jcm11123489</identifier><identifier>PMID: 35743559</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Ablation ; Age ; Births ; Body mass index ; Cesarean section ; Clinical medicine ; Endometrium ; Fallopian tubes ; Fertility ; Infertility ; Magnetic resonance imaging ; Miscarriage ; Pregnancy ; Reproductive technologies ; Statistical analysis ; Surgery ; Ultrasonic imaging ; Uterus</subject><ispartof>Journal of clinical medicine, 2022-06, Vol.11 (12), p.3489</ispartof><rights>2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2022 by the authors. 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c409t-bcdbbea8339cb04390f93d3c27e70a950c7312b7ca9ab1cf5ab80fedd3c514053</citedby><cites>FETCH-LOGICAL-c409t-bcdbbea8339cb04390f93d3c27e70a950c7312b7ca9ab1cf5ab80fedd3c514053</cites><orcidid>0000-0001-7122-6435 ; 0000-0001-7812-8280 ; 0000-0002-2121-0723</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9224895/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9224895/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35743559$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhou, Yong</creatorcontrib><creatorcontrib>Shen, Li</creatorcontrib><creatorcontrib>Wang, Yuan</creatorcontrib><creatorcontrib>Yang, Mengjia</creatorcontrib><creatorcontrib>Chen, Zhengyun</creatorcontrib><creatorcontrib>Zhang, Xinmei</creatorcontrib><title>Long-Term Pregnancy Outcomes of Patients with Diffuse Adenomyosis after Double-Flap Adenomyomectomy</title><title>Journal of clinical medicine</title><addtitle>J Clin Med</addtitle><description>Although many studies show that patients with diffuse adenomyosis who underwent fertility-sparing surgery can have a successful pregnancy, their pregnancy outcomes are still controversial. The objective of this study was to determine long-term pregnancy outcomes and possible influencing factors after double-flap adenomyomectomy for patients with diffuse adenomyosis. A total of 137 patients with diffuse adenomyosis who underwent double-flap adenomyomectomy between January 2011 and December 2019 were studied, and correlations between pregnancy outcomes and clinical data, including age and junctional zone measured by magnetic resonance imaging (JZmax-A), were analyzed. The results show that 56 patients (40.9%, 56/137) had 62 pregnancies, including 35 natural pregnancies and 27 assisted reproduction pregnancies, after operation. A univariate regression analysis showed that the pregnancy outcomes were related to age at surgery, visual analog scale (VAS) score of preoperative dysmenorrhea, parity experience, length of infertility, and postoperative JZmax-A. A multivariate regression analysis showed that age at surgery, VAS score of preoperative dysmenorrhea, and postoperative JZmax-A were the independent indicators correlated with pregnancy outcomes. A receiver operating characteristic curve analysis showed that postoperative JZmax-A was the most valuable indicator for predicting pregnancy outcomes. Cumulative pregnancy rates during the first 3 years were 70.1% and 20.9% in the postoperative JZmax-A ≤ 8.5 mm and the postoperative JZmax-A > 8.5 mm groups, respectively. In conclusion, double-flap adenomyomectomy could improve fertility for diffuse adenomyosis, and postoperative JZmax-A might be a promising indicator for predicting pregnancy outcomes.</description><subject>Ablation</subject><subject>Age</subject><subject>Births</subject><subject>Body mass index</subject><subject>Cesarean section</subject><subject>Clinical medicine</subject><subject>Endometrium</subject><subject>Fallopian tubes</subject><subject>Fertility</subject><subject>Infertility</subject><subject>Magnetic resonance imaging</subject><subject>Miscarriage</subject><subject>Pregnancy</subject><subject>Reproductive technologies</subject><subject>Statistical analysis</subject><subject>Surgery</subject><subject>Ultrasonic imaging</subject><subject>Uterus</subject><issn>2077-0383</issn><issn>2077-0383</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNpdkc1LAzEQxYMoKurJuwS8CLKabLLN5iJI_YRCe9BzSLKTumV3U5Ndpf-9KWqp5jKB-fF4bx5Cp5RcMSbJ9cK2lNKc8VLuoMOcCJERVrLdrf8BOolxQdIrS55TsY8OWCE4Kwp5iOzEd_PsBUKLZwHmne7sCk-H3voWIvYOz3RfQ9dH_Fn3b_iudm6IgG8r6Hy78rGOWLseAr7zg2kge2j0crNtwfZpHqM9p5sIJz_zCL0-3L-Mn7LJ9PF5fDvJLCeyz4ytjAFdplzWEJ7SOckqZnMBgmhZECsYzY2wWmpDrSu0KYmDKiEF5aRgR-jmW3c5mBYqm2wH3ahlqFsdVsrrWv3ddPWbmvsPJfM83W8tcPEjEPz7ALFXbR0tNI3uwA9R5aOSEr4-dkLP_6ELP4QuxUuUkILz0Ygm6vKbssHHGMBtzFCi1v2prf4Sfbbtf8P-tsW-AM6Ml9M</recordid><startdate>20220617</startdate><enddate>20220617</enddate><creator>Zhou, Yong</creator><creator>Shen, Li</creator><creator>Wang, Yuan</creator><creator>Yang, Mengjia</creator><creator>Chen, Zhengyun</creator><creator>Zhang, Xinmei</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-7122-6435</orcidid><orcidid>https://orcid.org/0000-0001-7812-8280</orcidid><orcidid>https://orcid.org/0000-0002-2121-0723</orcidid></search><sort><creationdate>20220617</creationdate><title>Long-Term Pregnancy Outcomes of Patients with Diffuse Adenomyosis after Double-Flap Adenomyomectomy</title><author>Zhou, Yong ; Shen, Li ; Wang, Yuan ; Yang, Mengjia ; Chen, Zhengyun ; Zhang, Xinmei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c409t-bcdbbea8339cb04390f93d3c27e70a950c7312b7ca9ab1cf5ab80fedd3c514053</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Ablation</topic><topic>Age</topic><topic>Births</topic><topic>Body mass index</topic><topic>Cesarean section</topic><topic>Clinical medicine</topic><topic>Endometrium</topic><topic>Fallopian tubes</topic><topic>Fertility</topic><topic>Infertility</topic><topic>Magnetic resonance imaging</topic><topic>Miscarriage</topic><topic>Pregnancy</topic><topic>Reproductive technologies</topic><topic>Statistical analysis</topic><topic>Surgery</topic><topic>Ultrasonic imaging</topic><topic>Uterus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhou, Yong</creatorcontrib><creatorcontrib>Shen, Li</creatorcontrib><creatorcontrib>Wang, Yuan</creatorcontrib><creatorcontrib>Yang, Mengjia</creatorcontrib><creatorcontrib>Chen, Zhengyun</creatorcontrib><creatorcontrib>Zhang, Xinmei</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Health and Medical</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of clinical medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhou, Yong</au><au>Shen, Li</au><au>Wang, Yuan</au><au>Yang, Mengjia</au><au>Chen, Zhengyun</au><au>Zhang, Xinmei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Long-Term Pregnancy Outcomes of Patients with Diffuse Adenomyosis after Double-Flap Adenomyomectomy</atitle><jtitle>Journal of clinical medicine</jtitle><addtitle>J Clin Med</addtitle><date>2022-06-17</date><risdate>2022</risdate><volume>11</volume><issue>12</issue><spage>3489</spage><pages>3489-</pages><issn>2077-0383</issn><eissn>2077-0383</eissn><abstract>Although many studies show that patients with diffuse adenomyosis who underwent fertility-sparing surgery can have a successful pregnancy, their pregnancy outcomes are still controversial. The objective of this study was to determine long-term pregnancy outcomes and possible influencing factors after double-flap adenomyomectomy for patients with diffuse adenomyosis. A total of 137 patients with diffuse adenomyosis who underwent double-flap adenomyomectomy between January 2011 and December 2019 were studied, and correlations between pregnancy outcomes and clinical data, including age and junctional zone measured by magnetic resonance imaging (JZmax-A), were analyzed. The results show that 56 patients (40.9%, 56/137) had 62 pregnancies, including 35 natural pregnancies and 27 assisted reproduction pregnancies, after operation. A univariate regression analysis showed that the pregnancy outcomes were related to age at surgery, visual analog scale (VAS) score of preoperative dysmenorrhea, parity experience, length of infertility, and postoperative JZmax-A. A multivariate regression analysis showed that age at surgery, VAS score of preoperative dysmenorrhea, and postoperative JZmax-A were the independent indicators correlated with pregnancy outcomes. A receiver operating characteristic curve analysis showed that postoperative JZmax-A was the most valuable indicator for predicting pregnancy outcomes. Cumulative pregnancy rates during the first 3 years were 70.1% and 20.9% in the postoperative JZmax-A ≤ 8.5 mm and the postoperative JZmax-A > 8.5 mm groups, respectively. In conclusion, double-flap adenomyomectomy could improve fertility for diffuse adenomyosis, and postoperative JZmax-A might be a promising indicator for predicting pregnancy outcomes.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>35743559</pmid><doi>10.3390/jcm11123489</doi><orcidid>https://orcid.org/0000-0001-7122-6435</orcidid><orcidid>https://orcid.org/0000-0001-7812-8280</orcidid><orcidid>https://orcid.org/0000-0002-2121-0723</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2077-0383 |
| ispartof | Journal of clinical medicine, 2022-06, Vol.11 (12), p.3489 |
| issn | 2077-0383 2077-0383 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9224895 |
| source | MDPI - Multidisciplinary Digital Publishing Institute; PubMed Central(OpenAccess); EZB*; PubMed Central Open Access |
| subjects | Ablation Age Births Body mass index Cesarean section Clinical medicine Endometrium Fallopian tubes Fertility Infertility Magnetic resonance imaging Miscarriage Pregnancy Reproductive technologies Statistical analysis Surgery Ultrasonic imaging Uterus |
| title | Long-Term Pregnancy Outcomes of Patients with Diffuse Adenomyosis after Double-Flap Adenomyomectomy |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-28T07%3A30%3A28IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Long-Term%20Pregnancy%20Outcomes%20of%20Patients%20with%20Diffuse%20Adenomyosis%20after%20Double-Flap%20Adenomyomectomy&rft.jtitle=Journal%20of%20clinical%20medicine&rft.au=Zhou,%20Yong&rft.date=2022-06-17&rft.volume=11&rft.issue=12&rft.spage=3489&rft.pages=3489-&rft.issn=2077-0383&rft.eissn=2077-0383&rft_id=info:doi/10.3390/jcm11123489&rft_dat=%3Cproquest_pubme%3E2679744661%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2679744661&rft_id=info:pmid/35743559&rfr_iscdi=true |