Cancer Malignancy Is Correlated with Upregulation of PCYT2-Mediated Glycerol Phosphate Modification of α-Dystroglycan

The dystrophin–glycoprotein complex connects the cytoskeleton with base membrane components such as laminin through unique O-glycans displayed on α-dystroglycan (α-DG). Genetic impairment of elongation of these glycans causes congenital muscular dystrophies. We previously identified that glycerol ph...

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Veröffentlicht in:	International journal of molecular sciences 2022-06, Vol.23 (12), p.6662
Hauptverfasser:	Umezawa, Fumiko, Natsume, Makoto, Fukusada, Shigeki, Nakajima, Kazuki, Yamasaki, Fumiya, Kawashima, Hiroto, Kuo, Chu-Wei, Khoo, Kay-Hooi, Shimura, Takaya, Yagi, Hirokazu, Kato, Koichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Cancer Cell adhesion Cell adhesion & migration Colorectal cancer Colorectal carcinoma Correlation Cytoskeleton Dystroglycan Dystrophin Elongation Enzymes Extracellular matrix Glycan Glycerol Gram-positive bacteria Laminin Malignancy Metastases Polysaccharides Proteins
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