Efficacy of Methylprednisolone Compared to Other Drugs for Pain, Swelling, and Trismus Control after Third Molar Surgery: A Meta-Analysis
The purpose of this systematic review and meta-analysis was to assess the efficacy of methylprednisolone compared to other drugs to control postoperative complications following third molar surgery. PubMed and Google Scholar were used for article searching. Thereafter, the trials meeting the selecti...
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| Veröffentlicht in: | Healthcare (Basel) 2022-06, Vol.10 (6), p.1028 |
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| creator | González-Morelos, Mariana Franco-de la Torre, Lorenzo Franco-González, Diana Laura Gómez-Sánchez, Eduardo Alonso-Castro, Ángel Josabad Molina-Frechero, Nelly Anaya-Esparza, Luis Miguel Isiordia-Espinoza, Mario Alberto |
| description | The purpose of this systematic review and meta-analysis was to assess the efficacy of methylprednisolone compared to other drugs to control postoperative complications following third molar surgery. PubMed and Google Scholar were used for article searching. Thereafter, the trials meeting the selection criteria and with high methodological quality, according to the Cochrane Collaboration’s risk of bias tool, were included in this study. The inverse variance test and mean difference using the Review Manager Software 5.3 for Windows were used to carry out data analysis. Qualitative analysis shows that methylprednisolone is more effective than NSAIDs, but inferior to dexamethasone, for controlling postoperative complications after third molar removal. The quantitative analysis showed no statistical difference for pain control, while trismus evaluation showed a statistical difference after 7 postoperative days in favor of methylprednisolone, when compared to other drugs. In conclusion, methylprednisolone was more effective for trismus control compared to other drugs after lower third molar surgery. |
| doi_str_mv | 10.3390/healthcare10061028 |
| format | Article |
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PubMed and Google Scholar were used for article searching. Thereafter, the trials meeting the selection criteria and with high methodological quality, according to the Cochrane Collaboration’s risk of bias tool, were included in this study. The inverse variance test and mean difference using the Review Manager Software 5.3 for Windows were used to carry out data analysis. Qualitative analysis shows that methylprednisolone is more effective than NSAIDs, but inferior to dexamethasone, for controlling postoperative complications after third molar removal. The quantitative analysis showed no statistical difference for pain control, while trismus evaluation showed a statistical difference after 7 postoperative days in favor of methylprednisolone, when compared to other drugs. In conclusion, methylprednisolone was more effective for trismus control compared to other drugs after lower third molar surgery.</description><identifier>ISSN: 2227-9032</identifier><identifier>EISSN: 2227-9032</identifier><identifier>DOI: 10.3390/healthcare10061028</identifier><identifier>PMID: 35742079</identifier><language>eng</language><publisher>Basel: MDPI AG</publisher><subject>Analgesics ; Anti-inflammatory agents ; Bias ; Clinical trials ; Collaboration ; Inflammation ; Meta-analysis ; Mouth ; Nonsteroidal anti-inflammatory drugs ; Pain ; Review ; Statistical analysis ; Steroids ; Surgery ; Systematic review</subject><ispartof>Healthcare (Basel), 2022-06, Vol.10 (6), p.1028</ispartof><rights>2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). 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Franco-de la Torre, Lorenzo ; Franco-González, Diana Laura ; Gómez-Sánchez, Eduardo ; Alonso-Castro, Ángel Josabad ; Molina-Frechero, Nelly ; Anaya-Esparza, Luis Miguel ; Isiordia-Espinoza, Mario Alberto</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c407t-2096ac2bfa401cc8c01200ebd134eb31824a2852be40d3739e49e12a157dfe7b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Analgesics</topic><topic>Anti-inflammatory agents</topic><topic>Bias</topic><topic>Clinical trials</topic><topic>Collaboration</topic><topic>Inflammation</topic><topic>Meta-analysis</topic><topic>Mouth</topic><topic>Nonsteroidal anti-inflammatory drugs</topic><topic>Pain</topic><topic>Review</topic><topic>Statistical analysis</topic><topic>Steroids</topic><topic>Surgery</topic><topic>Systematic review</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>González-Morelos, Mariana</creatorcontrib><creatorcontrib>Franco-de la Torre, Lorenzo</creatorcontrib><creatorcontrib>Franco-González, Diana Laura</creatorcontrib><creatorcontrib>Gómez-Sánchez, Eduardo</creatorcontrib><creatorcontrib>Alonso-Castro, Ángel Josabad</creatorcontrib><creatorcontrib>Molina-Frechero, Nelly</creatorcontrib><creatorcontrib>Anaya-Esparza, Luis Miguel</creatorcontrib><creatorcontrib>Isiordia-Espinoza, Mario Alberto</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Healthcare (Basel)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>González-Morelos, Mariana</au><au>Franco-de la Torre, Lorenzo</au><au>Franco-González, Diana Laura</au><au>Gómez-Sánchez, Eduardo</au><au>Alonso-Castro, Ángel Josabad</au><au>Molina-Frechero, Nelly</au><au>Anaya-Esparza, Luis Miguel</au><au>Isiordia-Espinoza, Mario Alberto</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Efficacy of Methylprednisolone Compared to Other Drugs for Pain, Swelling, and Trismus Control after Third Molar Surgery: A Meta-Analysis</atitle><jtitle>Healthcare (Basel)</jtitle><date>2022-06-01</date><risdate>2022</risdate><volume>10</volume><issue>6</issue><spage>1028</spage><pages>1028-</pages><issn>2227-9032</issn><eissn>2227-9032</eissn><abstract>The purpose of this systematic review and meta-analysis was to assess the efficacy of methylprednisolone compared to other drugs to control postoperative complications following third molar surgery. 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| fulltext | fulltext |
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| ispartof | Healthcare (Basel), 2022-06, Vol.10 (6), p.1028 |
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| source | MDPI - Multidisciplinary Digital Publishing Institute; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access |
| subjects | Analgesics Anti-inflammatory agents Bias Clinical trials Collaboration Inflammation Meta-analysis Mouth Nonsteroidal anti-inflammatory drugs Pain Review Statistical analysis Steroids Surgery Systematic review |
| title | Efficacy of Methylprednisolone Compared to Other Drugs for Pain, Swelling, and Trismus Control after Third Molar Surgery: A Meta-Analysis |
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