Environmental Contaminants Modulate Breast Cancer Development and Outcome in TP53 p.R337H Carriers and Noncarriers
Two major concerns associated with cancer development in Paraná state, South Brazil, are environmental pollution and the germline TP53 p.R337H variant found in 0.27−0.30% of the population. We assessed breast cancer (BC) risk in rural (C1 and C2) and industrialized (C3) subregions, previously classi...
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| Veröffentlicht in: | Cancers 2022-06, Vol.14 (12), p.3014 |
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| creator | Gerber, Viviane K Q Paraizo, Mariana M Ibañez, Humberto C Casali-da-Rocha, José C Pinto, Emilia M Andrade, Diancarlos P Ibañez, Marilea V C Komechen, Heloisa Figueiredo, Mirna M O Custódio, Gislaine Fiori, Carmem M C M Balbinotti, José H G Nardin, Jeanine M Almeida, Thais A Beltrame, Olair O Yamada, Paula A de Fraga, Gabriel S de Brito, Lucas L Martins, Jamylle Melanda, Viviane S Licht, Otavio A B Teixeira, Victoria Z Pinho, Sandy K S Bottini, Silvia Lalli, Enzo Zambetti, Gerard P Figueiredo, Bonald C |
| description | Two major concerns associated with cancer development in Paraná state, South Brazil, are environmental pollution and the germline TP53 p.R337H variant found in 0.27−0.30% of the population. We assessed breast cancer (BC) risk in rural (C1 and C2) and industrialized (C3) subregions, previously classified by geochemistry, agricultural productivity, and population density. C2 presents lower organochloride levels in rivers and lower agricultural outputs than C1, and lower levels of chlorine anions in rivers and lower industrial activities than C3. TP53 p.R337H status was assessed in 4658 women aged >30 years from C1, C2, and C3, subsequent to a genetic screening (Group 1, longitudinal study). BC risk in this group was 4.58 times higher among TP53 p.R337H carriers. BC prevalence and risk were significantly lower in C2 compared to that in C3. Mortality rate and risk associated with BC in women aged >30 years (n = 8181 deceased women; Group 2) were also lower in C2 than those in C3 and C1. These results suggest that environmental factors modulate BC risk and outcome in carriers and noncarriers. |
| doi_str_mv | 10.3390/cancers14123014 |
| format | Article |
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We assessed breast cancer (BC) risk in rural (C1 and C2) and industrialized (C3) subregions, previously classified by geochemistry, agricultural productivity, and population density. C2 presents lower organochloride levels in rivers and lower agricultural outputs than C1, and lower levels of chlorine anions in rivers and lower industrial activities than C3. TP53 p.R337H status was assessed in 4658 women aged >30 years from C1, C2, and C3, subsequent to a genetic screening (Group 1, longitudinal study). BC risk in this group was 4.58 times higher among TP53 p.R337H carriers. BC prevalence and risk were significantly lower in C2 compared to that in C3. Mortality rate and risk associated with BC in women aged >30 years (n = 8181 deceased women; Group 2) were also lower in C2 than those in C3 and C1. These results suggest that environmental factors modulate BC risk and outcome in carriers and noncarriers.</description><identifier>ISSN: 2072-6694</identifier><identifier>EISSN: 2072-6694</identifier><identifier>DOI: 10.3390/cancers14123014</identifier><identifier>PMID: 35740679</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Agriculture ; Air pollution ; Anions ; Basins ; Body mass index ; Breast cancer ; Chloride ; Chlorine ; Contaminants ; Environmental factors ; Epigenetics ; Genetic counseling ; Genetic screening ; Geochemistry ; Medical diagnosis ; Mortality ; Mutation ; p53 Protein ; Pesticides ; Pollutants ; Population density ; Tumor suppression ; Tumors ; Womens health</subject><ispartof>Cancers, 2022-06, Vol.14 (12), p.3014</ispartof><rights>2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). 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We assessed breast cancer (BC) risk in rural (C1 and C2) and industrialized (C3) subregions, previously classified by geochemistry, agricultural productivity, and population density. C2 presents lower organochloride levels in rivers and lower agricultural outputs than C1, and lower levels of chlorine anions in rivers and lower industrial activities than C3. TP53 p.R337H status was assessed in 4658 women aged >30 years from C1, C2, and C3, subsequent to a genetic screening (Group 1, longitudinal study). BC risk in this group was 4.58 times higher among TP53 p.R337H carriers. BC prevalence and risk were significantly lower in C2 compared to that in C3. Mortality rate and risk associated with BC in women aged >30 years (n = 8181 deceased women; Group 2) were also lower in C2 than those in C3 and C1. These results suggest that environmental factors modulate BC risk and outcome in carriers and noncarriers.</description><subject>Agriculture</subject><subject>Air pollution</subject><subject>Anions</subject><subject>Basins</subject><subject>Body mass index</subject><subject>Breast cancer</subject><subject>Chloride</subject><subject>Chlorine</subject><subject>Contaminants</subject><subject>Environmental factors</subject><subject>Epigenetics</subject><subject>Genetic counseling</subject><subject>Genetic screening</subject><subject>Geochemistry</subject><subject>Medical diagnosis</subject><subject>Mortality</subject><subject>Mutation</subject><subject>p53 Protein</subject><subject>Pesticides</subject><subject>Pollutants</subject><subject>Population density</subject><subject>Tumor suppression</subject><subject>Tumors</subject><subject>Womens 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These results suggest that environmental factors modulate BC risk and outcome in carriers and noncarriers.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>35740679</pmid><doi>10.3390/cancers14123014</doi><orcidid>https://orcid.org/0000-0003-0880-898X</orcidid><orcidid>https://orcid.org/0000-0001-8138-8892</orcidid><orcidid>https://orcid.org/0000-0001-5567-000X</orcidid><orcidid>https://orcid.org/0000-0003-3569-7090</orcidid><orcidid>https://orcid.org/0000-0002-0605-4646</orcidid><orcidid>https://orcid.org/0000-0002-1814-3689</orcidid><orcidid>https://orcid.org/0000-0002-1838-2153</orcidid><orcidid>https://orcid.org/0000-0002-0929-5007</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2072-6694 |
| ispartof | Cancers, 2022-06, Vol.14 (12), p.3014 |
| issn | 2072-6694 2072-6694 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9221344 |
| source | MDPI - Multidisciplinary Digital Publishing Institute; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access |
| subjects | Agriculture Air pollution Anions Basins Body mass index Breast cancer Chloride Chlorine Contaminants Environmental factors Epigenetics Genetic counseling Genetic screening Geochemistry Medical diagnosis Mortality Mutation p53 Protein Pesticides Pollutants Population density Tumor suppression Tumors Womens health |
| title | Environmental Contaminants Modulate Breast Cancer Development and Outcome in TP53 p.R337H Carriers and Noncarriers |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-28T04%3A20%3A15IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Environmental%20Contaminants%20Modulate%20Breast%20Cancer%20Development%20and%20Outcome%20in%20TP53%20p.R337H%20Carriers%20and%20Noncarriers&rft.jtitle=Cancers&rft.au=Gerber,%20Viviane%20K%20Q&rft.date=2022-06-19&rft.volume=14&rft.issue=12&rft.spage=3014&rft.pages=3014-&rft.issn=2072-6694&rft.eissn=2072-6694&rft_id=info:doi/10.3390/cancers14123014&rft_dat=%3Cproquest_pubme%3E2679686815%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2679686815&rft_id=info:pmid/35740679&rfr_iscdi=true |