Ferrostatin‑1 alleviates oxalate‑induced renal tubular epithelial cell injury, fibrosis and calcium oxalate stone formation by inhibiting ferroptosis

The present study aimed to evaluate the role and mechanism of ferrostatin‑1 (Fer‑1) in oxalate (Ox)‑induced renal tubular epithelial cell injury, fibrosis, and calcium oxalate (CaOx) stone formation. A CaOx model in mice kidneys was established via intraperitoneal injection of 80 mg/kg glyoxylic aci...

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Veröffentlicht in:	Molecular medicine reports 2022-08, Vol.26 (2), Article 256
Hauptverfasser:	Xie, Jinna, Ye, Zehua, Li, Lei, Xia, Yuqi, Yuan, Run, Ruan, Yuan, Zhou, Xiangjun
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Antigens Apoptosis Biotechnology Calcium oxalate Care and treatment Cell death Cell injury Diagnosis E-cadherin Epithelial cells Ferroptosis Fibrosis Flow cytometry Glutathione peroxidase Glyoxylic acid Health aspects Heme Immunofluorescence Kidney stones Kidneys Laboratory animals Mitochondria Oxalates Oxalic acid Oxygenase Properties Reactive oxygen species Risk factors Superoxide dismutase Transmission electron microscopes Vimentin
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