The role of endogenous Smad7 in regulating macrophage phenotype following myocardial infarction

Smad7 restrains TGF‐β responses, and has been suggested to exert both pro‐ and anti‐inflammatory actions that may involve effects on macrophages. Myocardial infarction triggers a macrophage‐driven inflammatory response that not only plays a central role in cardiac repair, but also contributes to adv...

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Veröffentlicht in:	The FASEB journal 2022-07, Vol.36 (7), p.e22400-n/a
Hauptverfasser:	Li, Jun, Li, Ruoshui, Tuleta, Izabela, Hernandez, Silvia C., Humeres, Claudio, Hanna, Anis, Chen, Bijun, Frangogiannis, Nikolaos G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Fibrosis Inflammation macrophage Macrophages - metabolism Mice myocardial infarction Myocardial Infarction - genetics Myocardial Infarction - metabolism Phenotype Smad7 Protein - genetics Smad7 Protein - metabolism TGF‐β Transforming Growth Factor beta - metabolism
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