Dosimetric and radiobiological comparison in head-and-neck radiotherapy using JO-IMRT and 3D-CRT
Dosimetric and radiobiological evaluations for the Jaws-only Intensity-modulated radiotherapy (JO-IMRT) technique for head and neck jaws-only intensity-modulated radiation therapy (JO-IMRT) and 3D conformal radiation therapy (3D-CRT). To compare the head-and-neck therapeutic approaches utilizing JO-...
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| Veröffentlicht in: | Saudi journal of biological sciences 2022-08, Vol.29 (8), p.103336-103336, Article 103336 |
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| container_title | Saudi journal of biological sciences |
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| creator | Tai, Duong Thanh Oanh, Luong Thi Phuong, Pham Hoai Sulieman, Abdelmoneim Abolaban, Fouad A. Omer, Hiba Chow, James C.L. |
| description | Dosimetric and radiobiological evaluations for the Jaws-only Intensity-modulated radiotherapy (JO-IMRT) technique for head and neck jaws-only intensity-modulated radiation therapy (JO-IMRT) and 3D conformal radiation therapy (3D-CRT). To compare the head-and-neck therapeutic approaches utilizing JO-IMRT and 3D-CRT techniques, different radiation dose indices were calculated, including: conformity index (CI), homogeneity index (HI), and radiobiological variables like Niemierko's equivalent uniform dose based tumor control probability (TCP) of planning target volume (PTV), normal tissue complication probability (NTCP) of organs at risk (OAR) (brainstem, spinal cord, and parotid grand).
Twenty-five nasopharynx patients were studied using the Prowess Panther Treatment Planning System (Prowess Inc). The results were compared with the dose distribution obtained using 3D-CRT.
Regarding tumor coverage and CI, JO-IMRT showed better results than 3D-CRT. The average doses received by the PTVs were quite similar: 72.1 ± 0.8 Gy by 3D-CRT and 72.5 ± 0.6 Gy by JO-IMRT plans (p > 0.05). The mean doses received by the parotid gland were 56.7 ± 0.7 Gy by 3D-CRT and 26.8 ± 0.3 Gy by JO-IMRT (p > 0.05). The HI and CI were 0.13 ± 0.01 and 0.14 ± 0.05 and (p > 0.05) by 3D-CRT and 0.83 ± 0.05 and 0.73 ± 0.10 by JO-IMRT (p |
| doi_str_mv | 10.1016/j.sjbs.2022.103336 |
| format | Article |
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Twenty-five nasopharynx patients were studied using the Prowess Panther Treatment Planning System (Prowess Inc). The results were compared with the dose distribution obtained using 3D-CRT.
Regarding tumor coverage and CI, JO-IMRT showed better results than 3D-CRT. The average doses received by the PTVs were quite similar: 72.1 ± 0.8 Gy by 3D-CRT and 72.5 ± 0.6 Gy by JO-IMRT plans (p > 0.05). The mean doses received by the parotid gland were 56.7 ± 0.7 Gy by 3D-CRT and 26.8 ± 0.3 Gy by JO-IMRT (p > 0.05). The HI and CI were 0.13 ± 0.01 and 0.14 ± 0.05 and (p > 0.05) by 3D-CRT and 0.83 ± 0.05 and 0.73 ± 0.10 by JO-IMRT (p < 0.05). The average TCP of PTV was 0.82 ± 0.08 by 3D-CRT and 0.92 ± 0.02 by JO-IMRT. Moreover, the NTCP of the parotid glands, brain stem, and spinal cord were lower using the JO-IMRT than 3D-CRT plans. In comparison to the 3D-CRT approach, the JO-IMRT technique was able to boost dose coverage to the PTV, improve the target's CI and HI, and spare the parotid glands. This suggests the power of the JO-IMRT over 3D-CRT in head-and-neck radiotherapy.</description><identifier>ISSN: 1319-562X</identifier><identifier>EISSN: 2213-7106</identifier><identifier>DOI: 10.1016/j.sjbs.2022.103336</identifier><identifier>PMID: 35754762</identifier><language>eng</language><publisher>Elsevier B.V</publisher><subject>3D-CRT technique ; Dosimetric and radiobiological evaluation ; Equivalent Uniform Dose (EUD) ; JO-IMRT technique ; Original ; Plan evaluation</subject><ispartof>Saudi journal of biological sciences, 2022-08, Vol.29 (8), p.103336-103336, Article 103336</ispartof><rights>2022 The Author(s)</rights><rights>2022 The Author(s) 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c432t-f4b921ba2180f968f22b0e118ea96a0b9dd65a0c9d1386cf50a478f574e051f43</citedby><cites>FETCH-LOGICAL-c432t-f4b921ba2180f968f22b0e118ea96a0b9dd65a0c9d1386cf50a478f574e051f43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9213241/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1319562X22002522$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,3537,27901,27902,53766,53768,65306</link.rule.ids></links><search><creatorcontrib>Tai, Duong Thanh</creatorcontrib><creatorcontrib>Oanh, Luong Thi</creatorcontrib><creatorcontrib>Phuong, Pham Hoai</creatorcontrib><creatorcontrib>Sulieman, Abdelmoneim</creatorcontrib><creatorcontrib>Abolaban, Fouad A.</creatorcontrib><creatorcontrib>Omer, Hiba</creatorcontrib><creatorcontrib>Chow, James C.L.</creatorcontrib><title>Dosimetric and radiobiological comparison in head-and-neck radiotherapy using JO-IMRT and 3D-CRT</title><title>Saudi journal of biological sciences</title><description>Dosimetric and radiobiological evaluations for the Jaws-only Intensity-modulated radiotherapy (JO-IMRT) technique for head and neck jaws-only intensity-modulated radiation therapy (JO-IMRT) and 3D conformal radiation therapy (3D-CRT). To compare the head-and-neck therapeutic approaches utilizing JO-IMRT and 3D-CRT techniques, different radiation dose indices were calculated, including: conformity index (CI), homogeneity index (HI), and radiobiological variables like Niemierko's equivalent uniform dose based tumor control probability (TCP) of planning target volume (PTV), normal tissue complication probability (NTCP) of organs at risk (OAR) (brainstem, spinal cord, and parotid grand).
Twenty-five nasopharynx patients were studied using the Prowess Panther Treatment Planning System (Prowess Inc). The results were compared with the dose distribution obtained using 3D-CRT.
Regarding tumor coverage and CI, JO-IMRT showed better results than 3D-CRT. The average doses received by the PTVs were quite similar: 72.1 ± 0.8 Gy by 3D-CRT and 72.5 ± 0.6 Gy by JO-IMRT plans (p > 0.05). The mean doses received by the parotid gland were 56.7 ± 0.7 Gy by 3D-CRT and 26.8 ± 0.3 Gy by JO-IMRT (p > 0.05). The HI and CI were 0.13 ± 0.01 and 0.14 ± 0.05 and (p > 0.05) by 3D-CRT and 0.83 ± 0.05 and 0.73 ± 0.10 by JO-IMRT (p < 0.05). The average TCP of PTV was 0.82 ± 0.08 by 3D-CRT and 0.92 ± 0.02 by JO-IMRT. Moreover, the NTCP of the parotid glands, brain stem, and spinal cord were lower using the JO-IMRT than 3D-CRT plans. In comparison to the 3D-CRT approach, the JO-IMRT technique was able to boost dose coverage to the PTV, improve the target's CI and HI, and spare the parotid glands. This suggests the power of the JO-IMRT over 3D-CRT in head-and-neck radiotherapy.</description><subject>3D-CRT technique</subject><subject>Dosimetric and radiobiological evaluation</subject><subject>Equivalent Uniform Dose (EUD)</subject><subject>JO-IMRT technique</subject><subject>Original</subject><subject>Plan evaluation</subject><issn>1319-562X</issn><issn>2213-7106</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp9kUFr3DAQhUVpaDZJ_0BPPvairUaSZRtKoWzaJiUhELbQmypL411tbWkjeQP59_HWodBLTwMz33sP5hHyDtgSGKgPu2XetXnJGefTQgihXpEF5yBoBUy9JgsQ0NBS8Z-n5CznHWOqFjW8IaeirEpZKb4gvy5j9gOOydvCBFck43xsfezjxlvTFzYOe5N8jqHwodiicXTCaED7e2bHLSazfyoO2YdN8f2OXt_er_9YiUu6ul9fkJPO9Bnfvsxz8uPrl_Xqit7cfbtefb6hVgo-0k62DYfWcKhZ16i647xlCFCjaZRhbeOcKg2zjQNRK9uVzMiq7spKIiuhk-KcfJp994d2QGcxjMn0ep_8YNKTjsbrfy_Bb_UmPuopVnAJk8H7F4MUHw6YRz34bLHvTcB4yJqrGqRsSs4mlM-oTTHnhN3fGGD6WI3e6WM1-liNnquZRB9nEU5fePSYdLYeg0XnE9pRu-j_J38GBbuWWQ</recordid><startdate>20220801</startdate><enddate>20220801</enddate><creator>Tai, Duong Thanh</creator><creator>Oanh, Luong Thi</creator><creator>Phuong, Pham Hoai</creator><creator>Sulieman, Abdelmoneim</creator><creator>Abolaban, Fouad A.</creator><creator>Omer, Hiba</creator><creator>Chow, James C.L.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>6I.</scope><scope>AAFTH</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20220801</creationdate><title>Dosimetric and radiobiological comparison in head-and-neck radiotherapy using JO-IMRT and 3D-CRT</title><author>Tai, Duong Thanh ; Oanh, Luong Thi ; Phuong, Pham Hoai ; Sulieman, Abdelmoneim ; Abolaban, Fouad A. ; Omer, Hiba ; Chow, James C.L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c432t-f4b921ba2180f968f22b0e118ea96a0b9dd65a0c9d1386cf50a478f574e051f43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>3D-CRT technique</topic><topic>Dosimetric and radiobiological evaluation</topic><topic>Equivalent Uniform Dose (EUD)</topic><topic>JO-IMRT technique</topic><topic>Original</topic><topic>Plan evaluation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tai, Duong Thanh</creatorcontrib><creatorcontrib>Oanh, Luong Thi</creatorcontrib><creatorcontrib>Phuong, Pham Hoai</creatorcontrib><creatorcontrib>Sulieman, Abdelmoneim</creatorcontrib><creatorcontrib>Abolaban, Fouad A.</creatorcontrib><creatorcontrib>Omer, Hiba</creatorcontrib><creatorcontrib>Chow, James C.L.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Saudi journal of biological sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tai, Duong Thanh</au><au>Oanh, Luong Thi</au><au>Phuong, Pham Hoai</au><au>Sulieman, Abdelmoneim</au><au>Abolaban, Fouad A.</au><au>Omer, Hiba</au><au>Chow, James C.L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dosimetric and radiobiological comparison in head-and-neck radiotherapy using JO-IMRT and 3D-CRT</atitle><jtitle>Saudi journal of biological sciences</jtitle><date>2022-08-01</date><risdate>2022</risdate><volume>29</volume><issue>8</issue><spage>103336</spage><epage>103336</epage><pages>103336-103336</pages><artnum>103336</artnum><issn>1319-562X</issn><eissn>2213-7106</eissn><abstract>Dosimetric and radiobiological evaluations for the Jaws-only Intensity-modulated radiotherapy (JO-IMRT) technique for head and neck jaws-only intensity-modulated radiation therapy (JO-IMRT) and 3D conformal radiation therapy (3D-CRT). To compare the head-and-neck therapeutic approaches utilizing JO-IMRT and 3D-CRT techniques, different radiation dose indices were calculated, including: conformity index (CI), homogeneity index (HI), and radiobiological variables like Niemierko's equivalent uniform dose based tumor control probability (TCP) of planning target volume (PTV), normal tissue complication probability (NTCP) of organs at risk (OAR) (brainstem, spinal cord, and parotid grand).
Twenty-five nasopharynx patients were studied using the Prowess Panther Treatment Planning System (Prowess Inc). The results were compared with the dose distribution obtained using 3D-CRT.
Regarding tumor coverage and CI, JO-IMRT showed better results than 3D-CRT. The average doses received by the PTVs were quite similar: 72.1 ± 0.8 Gy by 3D-CRT and 72.5 ± 0.6 Gy by JO-IMRT plans (p > 0.05). The mean doses received by the parotid gland were 56.7 ± 0.7 Gy by 3D-CRT and 26.8 ± 0.3 Gy by JO-IMRT (p > 0.05). The HI and CI were 0.13 ± 0.01 and 0.14 ± 0.05 and (p > 0.05) by 3D-CRT and 0.83 ± 0.05 and 0.73 ± 0.10 by JO-IMRT (p < 0.05). The average TCP of PTV was 0.82 ± 0.08 by 3D-CRT and 0.92 ± 0.02 by JO-IMRT. Moreover, the NTCP of the parotid glands, brain stem, and spinal cord were lower using the JO-IMRT than 3D-CRT plans. In comparison to the 3D-CRT approach, the JO-IMRT technique was able to boost dose coverage to the PTV, improve the target's CI and HI, and spare the parotid glands. This suggests the power of the JO-IMRT over 3D-CRT in head-and-neck radiotherapy.</abstract><pub>Elsevier B.V</pub><pmid>35754762</pmid><doi>10.1016/j.sjbs.2022.103336</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Saudi journal of biological sciences, 2022-08, Vol.29 (8), p.103336-103336, Article 103336 |
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| source | Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | 3D-CRT technique Dosimetric and radiobiological evaluation Equivalent Uniform Dose (EUD) JO-IMRT technique Original Plan evaluation |
| title | Dosimetric and radiobiological comparison in head-and-neck radiotherapy using JO-IMRT and 3D-CRT |
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