Application Value of Combined Detection of DCE-MRI and Serum Tumor Markers HE4, Ki67, and HK10 in the Diagnosis of Ovarian Cancer

Application Value of Combined Detection of DCE-MRI and Serum Tumor Markers HE4, Ki67, and HK10 in the Diagnosis of Ovarian Cancer

Objective. To investigate the application value of the combined detection of DCE-MRI and serum tumor markers (HE4, Ki67, and HK10) in the diagnosis of ovarian cancer. Methods. The clinical data of 40 patients with advanced ovarian cancer (AOC) confirmed by surgery and pathology in our hospital from...

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Veröffentlicht in:Contrast media and molecular imaging 2022-06, Vol.2022 (1), p.1533261-1533261
Hauptverfasser: Wang, Quanzhi, Dong, Hui, Zhou, Peng
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creator Wang, Quanzhi
Dong, Hui
Zhou, Peng
description Objective. To investigate the application value of the combined detection of DCE-MRI and serum tumor markers (HE4, Ki67, and HK10) in the diagnosis of ovarian cancer. Methods. The clinical data of 40 patients with advanced ovarian cancer (AOC) confirmed by surgery and pathology in our hospital from February 2019 to February 2020 were retrospectively analyzed. All patients received DCE-MRI, the detection of serum tumor markers HE4, Ki67, and HK10, and the combined detection of DCE-MRI and the serum tumor markers (HE4, Ki67, and HK10). The application value of the three detection methods was analyzed. Results. The number of true positives in the single detection (DCE-MRI detection and the detection of serum HE4, Ki67, and HK10) was notably lower than that in the combined detection. The sensitivity, specificity, and accuracy of the single detection were notably lower compared with the combined detection. The area under the curve in the ROC of the combined detection was notably larger than that of the single detection. The results of the combined detection were better than those of the single detection (P
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To investigate the application value of the combined detection of DCE-MRI and serum tumor markers (HE4, Ki67, and HK10) in the diagnosis of ovarian cancer. Methods. The clinical data of 40 patients with advanced ovarian cancer (AOC) confirmed by surgery and pathology in our hospital from February 2019 to February 2020 were retrospectively analyzed. All patients received DCE-MRI, the detection of serum tumor markers HE4, Ki67, and HK10, and the combined detection of DCE-MRI and the serum tumor markers (HE4, Ki67, and HK10). The application value of the three detection methods was analyzed. Results. The number of true positives in the single detection (DCE-MRI detection and the detection of serum HE4, Ki67, and HK10) was notably lower than that in the combined detection. The sensitivity, specificity, and accuracy of the single detection were notably lower compared with the combined detection. The area under the curve in the ROC of the combined detection was notably larger than that of the single detection. The results of the combined detection were better than those of the single detection (P&lt;0.05), with the highest sensitivity of the combined detection. Conclusion. The combined detection of DCE-MRI and the serum tumor markers (HE4, Ki67, and HK10) can effectively improve the diagnostic accuracy of AOC patients, with high sensitivity and specificity, which has an important diagnostic value in clinic.</description><identifier>ISSN: 1555-4309</identifier><identifier>EISSN: 1555-4317</identifier><identifier>DOI: 10.1155/2022/1533261</identifier><identifier>PMID: 35815060</identifier><language>eng</language><publisher>Hindawi</publisher><ispartof>Contrast media and molecular imaging, 2022-06, Vol.2022 (1), p.1533261-1533261</ispartof><rights>Copyright © 2022 Quanzhi Wang et al.</rights><rights>Copyright © 2022 Quanzhi Wang et al. 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c284t-10a1676eccd043ee3c579b307bca078191b2949d0ee9045644831a93bd0cef113</cites><orcidid>0000-0001-7609-5534</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9213144/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9213144/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids></links><search><contributor>Hashmi, Mohammad Farukh</contributor><creatorcontrib>Wang, Quanzhi</creatorcontrib><creatorcontrib>Dong, Hui</creatorcontrib><creatorcontrib>Zhou, Peng</creatorcontrib><title>Application Value of Combined Detection of DCE-MRI and Serum Tumor Markers HE4, Ki67, and HK10 in the Diagnosis of Ovarian Cancer</title><title>Contrast media and molecular imaging</title><description>Objective. To investigate the application value of the combined detection of DCE-MRI and serum tumor markers (HE4, Ki67, and HK10) in the diagnosis of ovarian cancer. Methods. The clinical data of 40 patients with advanced ovarian cancer (AOC) confirmed by surgery and pathology in our hospital from February 2019 to February 2020 were retrospectively analyzed. All patients received DCE-MRI, the detection of serum tumor markers HE4, Ki67, and HK10, and the combined detection of DCE-MRI and the serum tumor markers (HE4, Ki67, and HK10). The application value of the three detection methods was analyzed. Results. The number of true positives in the single detection (DCE-MRI detection and the detection of serum HE4, Ki67, and HK10) was notably lower than that in the combined detection. The sensitivity, specificity, and accuracy of the single detection were notably lower compared with the combined detection. The area under the curve in the ROC of the combined detection was notably larger than that of the single detection. The results of the combined detection were better than those of the single detection (P&lt;0.05), with the highest sensitivity of the combined detection. Conclusion. The combined detection of DCE-MRI and the serum tumor markers (HE4, Ki67, and HK10) can effectively improve the diagnostic accuracy of AOC patients, with high sensitivity and specificity, which has an important diagnostic value in clinic.</description><issn>1555-4309</issn><issn>1555-4317</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><recordid>eNp9kU9P3DAQxS1EBXTLjQ_gIxIb8MTOH1-QUHbbRYCQWuBqOc4s6zaxFzuh6rHfnCy7Quqlpxm999MbaR4hJ8DOAbLsImVpegEZ52kOe-RolLJEcCj2P3YmD8nnGH8yJgSX_IAc8qyEjOXsiPy9Wq9ba3RvvaNPuh2Q-iWtfFdbhw2dYY_m3RvVWTVP7r5fU-0a-gPD0NGHofOB3unwC0Oki7mY0hubF9N3ZHEDjFpH-xXSmdXPzkcbNzn3rzpY7WilncHwhXxa6jbi8W5OyOPX-UO1SG7vv11XV7eJSUvRJ8A05EWOxjRMcERuskLWnBW10awoQUKdSiEbhiiZyHIhSg5a8rphBpcAfEIut7nroe6wMej6oFu1DrbT4Y_y2qp_HWdX6tm_KpkCh_FzE3K6Cwj-ZcDYq85Gg22rHfohqjQvSyYBZDmi0y1qgo8x4PLjDDC1aU1tWlO71kb8bIuvrGv0b_t_-g3BjJMk</recordid><startdate>20220614</startdate><enddate>20220614</enddate><creator>Wang, Quanzhi</creator><creator>Dong, Hui</creator><creator>Zhou, Peng</creator><general>Hindawi</general><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-7609-5534</orcidid></search><sort><creationdate>20220614</creationdate><title>Application Value of Combined Detection of DCE-MRI and Serum Tumor Markers HE4, Ki67, and HK10 in the Diagnosis of Ovarian Cancer</title><author>Wang, Quanzhi ; Dong, Hui ; Zhou, Peng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c284t-10a1676eccd043ee3c579b307bca078191b2949d0ee9045644831a93bd0cef113</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Quanzhi</creatorcontrib><creatorcontrib>Dong, Hui</creatorcontrib><creatorcontrib>Zhou, Peng</creatorcontrib><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Contrast media and molecular imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Quanzhi</au><au>Dong, Hui</au><au>Zhou, Peng</au><au>Hashmi, Mohammad Farukh</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Application Value of Combined Detection of DCE-MRI and Serum Tumor Markers HE4, Ki67, and HK10 in the Diagnosis of Ovarian Cancer</atitle><jtitle>Contrast media and molecular imaging</jtitle><date>2022-06-14</date><risdate>2022</risdate><volume>2022</volume><issue>1</issue><spage>1533261</spage><epage>1533261</epage><pages>1533261-1533261</pages><issn>1555-4309</issn><eissn>1555-4317</eissn><abstract>Objective. To investigate the application value of the combined detection of DCE-MRI and serum tumor markers (HE4, Ki67, and HK10) in the diagnosis of ovarian cancer. Methods. The clinical data of 40 patients with advanced ovarian cancer (AOC) confirmed by surgery and pathology in our hospital from February 2019 to February 2020 were retrospectively analyzed. All patients received DCE-MRI, the detection of serum tumor markers HE4, Ki67, and HK10, and the combined detection of DCE-MRI and the serum tumor markers (HE4, Ki67, and HK10). The application value of the three detection methods was analyzed. Results. The number of true positives in the single detection (DCE-MRI detection and the detection of serum HE4, Ki67, and HK10) was notably lower than that in the combined detection. The sensitivity, specificity, and accuracy of the single detection were notably lower compared with the combined detection. The area under the curve in the ROC of the combined detection was notably larger than that of the single detection. The results of the combined detection were better than those of the single detection (P&lt;0.05), with the highest sensitivity of the combined detection. Conclusion. The combined detection of DCE-MRI and the serum tumor markers (HE4, Ki67, and HK10) can effectively improve the diagnostic accuracy of AOC patients, with high sensitivity and specificity, which has an important diagnostic value in clinic.</abstract><pub>Hindawi</pub><pmid>35815060</pmid><doi>10.1155/2022/1533261</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0001-7609-5534</orcidid><oa>free_for_read</oa></addata></record>
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title Application Value of Combined Detection of DCE-MRI and Serum Tumor Markers HE4, Ki67, and HK10 in the Diagnosis of Ovarian Cancer
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