The Effect of Rifampicin on Darunavir, Ritonavir, and Dolutegravir Exposure within Peripheral Blood Mononuclear Cells: a Dose Escalation Study

Ritonavir-boosted darunavir (DRV/r) and dolutegravir (DTG) are affected by induction of metabolizing enzymes and efflux transporters caused by rifampicin (RIF). This complicates the treatment of people living with HIV (PLWH) diagnosed with tuberculosis. Recent data showed that doubling DRV/r dose di...

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Veröffentlicht in:	Antimicrobial agents and chemotherapy 2022-06, Vol.66 (6), p.e0013622-e0013622
Hauptverfasser:	De Nicolò, Amedeo, Calcagno, Andrea, Motta, Ilaria, De Vivo, Elisa, D'Avolio, Antonio, Di Perri, Giovanni, Wiesner, Lubbe, Ebrahim, Isma-Eel, Maartens, Gary, Orrell, Catherine, McIlleron, Helen
Format:	Artikel
Sprache:	eng
Schlagworte:	Pharmacology
Online-Zugang:	Volltext
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