Animal models for studying COVID-19, prevention, and therapy: Pathology and disease phenotypes

Animal models for studying COVID-19, prevention, and therapy: Pathology and disease phenotypes

Translational models have played an important role in the rapid development of safe and effective vaccines and therapeutic agents for the ongoing coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Animal models recapitulating the clin...

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Veröffentlicht in:Veterinary Pathology 2022-07, Vol.59 (4), p.516-527
Hauptverfasser: Choudhary, Shambhunath, Kanevsky, Isis, Tomlinson, Lindsay
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container_title Veterinary Pathology
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creator Choudhary, Shambhunath
Kanevsky, Isis
Tomlinson, Lindsay
description Translational models have played an important role in the rapid development of safe and effective vaccines and therapeutic agents for the ongoing coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Animal models recapitulating the clinical and underlying pathological manifestations of COVID-19 have been vital for identification and rational design of safe and effective vaccines and therapies. This manuscript provides an overview of commonly used COVID-19 animal models and the pathologic features of SARS-CoV-2 infection in these models in relation to their clinical presentation in humans. Also discussed are considerations for selecting appropriate animal models for infectious diseases such as COVID-19, the host determinants that can influence species-specific susceptibility to SARS-CoV-2, and the pathogenesis of COVID-19. Finally, the limitations of currently available COVID-19 animal models are highlighted.
doi_str_mv 10.1177/03009858221092015
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title Animal models for studying COVID-19, prevention, and therapy: Pathology and disease phenotypes
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