Single, dual and multiple respiratory virus infections and risk of hospitalization and mortality
Respiratory virus infections cause a significant number of hospitalization and deaths globally. This study investigated the association between single and multiple respiratory virus infections and risk of admission to a general ward, intensive care unit or death in patients aged 0–105 years (mean ± ...
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| Veröffentlicht in: | Epidemiology and infection 2015-01, Vol.143 (1), p.37-47 |
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| creator | GOKA, E. A. VALLELY, P. J. MUTTON, K. J. KLAPPER, P. E. |
| description | Respiratory virus infections cause a significant number of hospitalization and deaths globally. This study investigated the association between single and multiple respiratory virus infections and risk of admission to a general ward, intensive care unit or death in patients aged 0–105 years (mean ± s.d. = 24·4 ± 24·1 years), from North West England, that were tested for respiratory virus infections between January 2007 and June 2012. The majority of infections were in children aged ⩽5 years. Dual or multiple infections occurred in 10·4% (1214/11 715) of patients, whereas single infection occurred in 89·6% (10 501/11 715). Rhinovirus was the most common co-infecting virus (occurring in 69·5%; 844/1214 of co-infections). In a multivariate logistic regression model, multiple infections were associated with an increased risk of admission to a general ward [odds ratio (OR) 1·43, 95% confidence interval (CI) 1·2–1·7, P |
| doi_str_mv | 10.1017/S0950268814000302 |
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A. ; VALLELY, P. J. ; MUTTON, K. J. ; KLAPPER, P. E.</creator><creatorcontrib>GOKA, E. A. ; VALLELY, P. J. ; MUTTON, K. J. ; KLAPPER, P. E.</creatorcontrib><description>Respiratory virus infections cause a significant number of hospitalization and deaths globally. This study investigated the association between single and multiple respiratory virus infections and risk of admission to a general ward, intensive care unit or death in patients aged 0–105 years (mean ± s.d. = 24·4 ± 24·1 years), from North West England, that were tested for respiratory virus infections between January 2007 and June 2012. The majority of infections were in children aged ⩽5 years. Dual or multiple infections occurred in 10·4% (1214/11 715) of patients, whereas single infection occurred in 89·6% (10 501/11 715). Rhinovirus was the most common co-infecting virus (occurring in 69·5%; 844/1214 of co-infections). In a multivariate logistic regression model, multiple infections were associated with an increased risk of admission to a general ward [odds ratio (OR) 1·43, 95% confidence interval (CI) 1·2–1·7, P < 0·0001]. On the other hand, patients with respiratory syncytial virus (RSV) and human parainfluenza virus types 1–3 (hPIV1–3), as a single infection, had a higher risk of being admitted to a general ward (OR 1·49, 95% CI 1·28–1·73, P < 0·0001 and OR 1·34, 95% CI 1·003–1·8, P = 0·05, respectively); admitted to an intensive-care unit or dying (OR 1·5, 95% CI 1·20–2·0, P = 0·001 and OR 1·60, 95% CI 1·02–2·40, P = 0·04, respectively). This result emphasizes the importance of RSV, hPIV and mixed infections and calls for research on vaccines, drugs and diagnostic tests targeting these respiratory viruses.</description><identifier>ISSN: 0950-2688</identifier><identifier>EISSN: 1469-4409</identifier><identifier>DOI: 10.1017/S0950268814000302</identifier><identifier>PMID: 24568719</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Child ; Child, Preschool ; Coinfection - epidemiology ; Coinfection - mortality ; Cross-Sectional Studies ; England - epidemiology ; Ethics ; Female ; Hospitalization ; Humans ; Infant ; Infant, Newborn ; Infections ; Influenza ; Influenza/Respiratory Viruses ; Male ; Middle Aged ; Mortality ; Original Papers ; Parainfluenza virus ; Patients ; Pneumonia ; R&D ; Research & development ; Respiratory syncytial virus ; Rhinovirus ; Survival Analysis ; Virus Diseases - epidemiology ; Virus Diseases - mortality ; Viruses ; Young Adult</subject><ispartof>Epidemiology and infection, 2015-01, Vol.143 (1), p.37-47</ispartof><rights>Copyright © Cambridge University Press 2014</rights><rights>Cambridge University Press 2014</rights><rights>Cambridge University Press 2014 2014 Cambridge University Press</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c644t-9124034ac4a9098833f11203a8e2a20ebb418ab5dfcff0efdba5ab25dd407d683</citedby><cites>FETCH-LOGICAL-c644t-9124034ac4a9098833f11203a8e2a20ebb418ab5dfcff0efdba5ab25dd407d683</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/26512591$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/26512591$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,723,776,780,799,881,27901,27902,53766,53768,57992,58225</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24568719$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>GOKA, E. A.</creatorcontrib><creatorcontrib>VALLELY, P. J.</creatorcontrib><creatorcontrib>MUTTON, K. J.</creatorcontrib><creatorcontrib>KLAPPER, P. E.</creatorcontrib><title>Single, dual and multiple respiratory virus infections and risk of hospitalization and mortality</title><title>Epidemiology and infection</title><addtitle>Epidemiol. Infect</addtitle><description>Respiratory virus infections cause a significant number of hospitalization and deaths globally. This study investigated the association between single and multiple respiratory virus infections and risk of admission to a general ward, intensive care unit or death in patients aged 0–105 years (mean ± s.d. = 24·4 ± 24·1 years), from North West England, that were tested for respiratory virus infections between January 2007 and June 2012. The majority of infections were in children aged ⩽5 years. Dual or multiple infections occurred in 10·4% (1214/11 715) of patients, whereas single infection occurred in 89·6% (10 501/11 715). Rhinovirus was the most common co-infecting virus (occurring in 69·5%; 844/1214 of co-infections). In a multivariate logistic regression model, multiple infections were associated with an increased risk of admission to a general ward [odds ratio (OR) 1·43, 95% confidence interval (CI) 1·2–1·7, P < 0·0001]. On the other hand, patients with respiratory syncytial virus (RSV) and human parainfluenza virus types 1–3 (hPIV1–3), as a single infection, had a higher risk of being admitted to a general ward (OR 1·49, 95% CI 1·28–1·73, P < 0·0001 and OR 1·34, 95% CI 1·003–1·8, P = 0·05, respectively); admitted to an intensive-care unit or dying (OR 1·5, 95% CI 1·20–2·0, P = 0·001 and OR 1·60, 95% CI 1·02–2·40, P = 0·04, respectively). This result emphasizes the importance of RSV, hPIV and mixed infections and calls for research on vaccines, drugs and diagnostic tests targeting these respiratory viruses.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Coinfection - epidemiology</subject><subject>Coinfection - mortality</subject><subject>Cross-Sectional Studies</subject><subject>England - epidemiology</subject><subject>Ethics</subject><subject>Female</subject><subject>Hospitalization</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Infections</subject><subject>Influenza</subject><subject>Influenza/Respiratory Viruses</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Original Papers</subject><subject>Parainfluenza virus</subject><subject>Patients</subject><subject>Pneumonia</subject><subject>R&D</subject><subject>Research & development</subject><subject>Respiratory syncytial virus</subject><subject>Rhinovirus</subject><subject>Survival Analysis</subject><subject>Virus Diseases - epidemiology</subject><subject>Virus Diseases - mortality</subject><subject>Viruses</subject><subject>Young Adult</subject><issn>0950-2688</issn><issn>1469-4409</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNkUtv1DAUhS1ERYfCD2ABisSGBYHrV2JvkFDFo1IlFoW1cWJ76sGJBzupNPx6nM7QFhASK0s-3z33cRB6guEVBty-vgDJgTRCYAYAFMg9tMKskTVjIO-j1SLXi36MHua8KYwkon2AjgnjjWixXKGvF35cB_uyMrMOlR5NNcxh8ttgq2Tz1ic9xbSrrnyac-VHZ_vJxzFfk8nnb1V01WUs4KSD_6EXce8S0_Iz7R6hI6dDto8P7wn68v7d59OP9fmnD2enb8_rvmFsqiUmDCjTPdMSpBCUOowJUC0s0QRs1zEsdMeN650D60ynue4IN4ZBaxpBT9Cbve927gZrejtOSQe1TX7Qaaei9up3ZfSXah2vlCTQCFgMXhwMUvw-2zypwefehqBHG-escMPLaTHQ9j9QygEYhaagz_9AN3FOY7nEQhVDKrAsFN5TfYo5J-tu5saglqjVX1GXmmd3F76p-JVtAZ7ugU0uGd7qDceES1x0emiqhy55s7Z3Zvtn259NbL5b</recordid><startdate>20150101</startdate><enddate>20150101</enddate><creator>GOKA, E. 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A.</au><au>VALLELY, P. J.</au><au>MUTTON, K. J.</au><au>KLAPPER, P. E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Single, dual and multiple respiratory virus infections and risk of hospitalization and mortality</atitle><jtitle>Epidemiology and infection</jtitle><addtitle>Epidemiol. Infect</addtitle><date>2015-01-01</date><risdate>2015</risdate><volume>143</volume><issue>1</issue><spage>37</spage><epage>47</epage><pages>37-47</pages><issn>0950-2688</issn><eissn>1469-4409</eissn><abstract>Respiratory virus infections cause a significant number of hospitalization and deaths globally. This study investigated the association between single and multiple respiratory virus infections and risk of admission to a general ward, intensive care unit or death in patients aged 0–105 years (mean ± s.d. = 24·4 ± 24·1 years), from North West England, that were tested for respiratory virus infections between January 2007 and June 2012. The majority of infections were in children aged ⩽5 years. Dual or multiple infections occurred in 10·4% (1214/11 715) of patients, whereas single infection occurred in 89·6% (10 501/11 715). Rhinovirus was the most common co-infecting virus (occurring in 69·5%; 844/1214 of co-infections). In a multivariate logistic regression model, multiple infections were associated with an increased risk of admission to a general ward [odds ratio (OR) 1·43, 95% confidence interval (CI) 1·2–1·7, P < 0·0001]. On the other hand, patients with respiratory syncytial virus (RSV) and human parainfluenza virus types 1–3 (hPIV1–3), as a single infection, had a higher risk of being admitted to a general ward (OR 1·49, 95% CI 1·28–1·73, P < 0·0001 and OR 1·34, 95% CI 1·003–1·8, P = 0·05, respectively); admitted to an intensive-care unit or dying (OR 1·5, 95% CI 1·20–2·0, P = 0·001 and OR 1·60, 95% CI 1·02–2·40, P = 0·04, respectively). This result emphasizes the importance of RSV, hPIV and mixed infections and calls for research on vaccines, drugs and diagnostic tests targeting these respiratory viruses.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>24568719</pmid><doi>10.1017/S0950268814000302</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Aged Aged, 80 and over Child Child, Preschool Coinfection - epidemiology Coinfection - mortality Cross-Sectional Studies England - epidemiology Ethics Female Hospitalization Humans Infant Infant, Newborn Infections Influenza Influenza/Respiratory Viruses Male Middle Aged Mortality Original Papers Parainfluenza virus Patients Pneumonia R&D Research & development Respiratory syncytial virus Rhinovirus Survival Analysis Virus Diseases - epidemiology Virus Diseases - mortality Viruses Young Adult |
| title | Single, dual and multiple respiratory virus infections and risk of hospitalization and mortality |
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