IFN-induced cell-autonomous immune mechanisms in the control of intracellular protozoa
Vertebrate cells have evolved an elaborate multi-tiered intracellular surveillance system linked to downstream antimicrobial effectors to defend themselves from pathogens. This cellular self-defense system is referred to as cell-autonomous immunity. A wide array of cell-autonomous mechanisms operate...
Gespeichert in:
| Veröffentlicht in: | Parasitology research (1987) 2022-06, Vol.121 (6), p.1559-1571 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1571 |
|---|---|
| container_issue | 6 |
| container_start_page | 1559 |
| container_title | Parasitology research (1987) |
| container_volume | 121 |
| creator | Skariah, Sini Sultan, Ali A. Mordue, Dana G. |
| description | Vertebrate cells have evolved an elaborate multi-tiered intracellular surveillance system linked to downstream antimicrobial effectors to defend themselves from pathogens. This cellular self-defense system is referred to as cell-autonomous immunity. A wide array of cell-autonomous mechanisms operates to control intracellular pathogens including protozoa such as
Toxoplasma gondii
. Cell-autonomous immunity consists of antimicrobial defenses that are constitutively active in cells and those that are inducible typically in response to host cell activation. The IFN family of cytokines is an important stimulator of inducible cell-autonomous immunity. There are several hundred interferon-stimulated genes (ISGs); many of them have known roles in inducible cell-autonomous immune mechanisms. The importance of IFN-γ activation of cell-autonomous immunity is evidenced by the fact that many intracellular pathogens have evolved a diversity of molecular mechanisms to inhibit activation of infected cells through the JAK-STAT pathway in response to IFN-γ. The goal of this review is to provide a broad framework for understanding the elaborate system of cell-autonomous immunity that acts as a first line of defense between a host and intracellular parasites. |
| doi_str_mv | 10.1007/s00436-022-07514-7 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9206464</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A703565710</galeid><sourcerecordid>A703565710</sourcerecordid><originalsourceid>FETCH-LOGICAL-c541t-8c1cd8ce96d66400cfc803b428d3db321a0e4d1124ac56e45dd0f18d9f43ed6f3</originalsourceid><addsrcrecordid>eNp9Uk1v1DAUtBCILoU_wAFF4tJLyvNnkgtSVVGoVLWXwtXy2i-7rhJ7sRMk-PV12FLaCiEfbD3PjDzjIeQthWMK0HzIAIKrGhiroZFU1M0zsqKCs5p2Uj4nK-jKGSjlB-RVzjcAtFFCvCQHXAouJWUr8u387LL2wc0WXWVxGGozTzHEMc658uM4B6xGtFsTfB7LJFTTFisbw5TiUMW-TKZkFuI8mFTtUpzir2hekxe9GTK-udsPydezT9enX-qLq8_npycXtZWCTnVrqXWtxU45pQSA7W0LfC1Y67hbc0YNoHCUMmGsVCikc9DT1nW94OhUzw_Jx73ubl6P6Cwurxn0LvnRpJ86Gq8f3wS_1Zv4Q3cMlFCiCBzdCaT4fcY86dHnxY4JWCLQTEkGHDohC_T9E-hNnFMo9gpKcdFK3j1AbcyA2oc-LvksovqkAS6VbCgU1PE_UGU5HH1JF3tf5o8IbE-wKeacsL_3SEEvbdD7NujSBv27DboppHcP07mn_Pn-AuB7QC5XYYPpr6X_yN4CgmG_1Q</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2663485395</pqid></control><display><type>article</type><title>IFN-induced cell-autonomous immune mechanisms in the control of intracellular protozoa</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Skariah, Sini ; Sultan, Ali A. ; Mordue, Dana G.</creator><creatorcontrib>Skariah, Sini ; Sultan, Ali A. ; Mordue, Dana G.</creatorcontrib><description>Vertebrate cells have evolved an elaborate multi-tiered intracellular surveillance system linked to downstream antimicrobial effectors to defend themselves from pathogens. This cellular self-defense system is referred to as cell-autonomous immunity. A wide array of cell-autonomous mechanisms operates to control intracellular pathogens including protozoa such as
Toxoplasma gondii
. Cell-autonomous immunity consists of antimicrobial defenses that are constitutively active in cells and those that are inducible typically in response to host cell activation. The IFN family of cytokines is an important stimulator of inducible cell-autonomous immunity. There are several hundred interferon-stimulated genes (ISGs); many of them have known roles in inducible cell-autonomous immune mechanisms. The importance of IFN-γ activation of cell-autonomous immunity is evidenced by the fact that many intracellular pathogens have evolved a diversity of molecular mechanisms to inhibit activation of infected cells through the JAK-STAT pathway in response to IFN-γ. The goal of this review is to provide a broad framework for understanding the elaborate system of cell-autonomous immunity that acts as a first line of defense between a host and intracellular parasites.</description><identifier>ISSN: 0932-0113</identifier><identifier>EISSN: 1432-1955</identifier><identifier>DOI: 10.1007/s00436-022-07514-7</identifier><identifier>PMID: 35435512</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Biological response modifiers ; Biomedical and Life Sciences ; Biomedicine ; Cell activation ; Immunity, Innate ; Immunology ; Immunology and Host-Parasite Interactions - Review ; Immunotherapy ; Interferon ; Interferon-gamma ; Intracellular ; Janus Kinases - metabolism ; Medical Microbiology ; Microbiology ; Molecular modelling ; Pathogens ; Signal Transduction ; STAT Transcription Factors ; Surveillance equipment ; Toxoplasma ; γ-Interferon</subject><ispartof>Parasitology research (1987), 2022-06, Vol.121 (6), p.1559-1571</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022</rights><rights>2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.</rights><rights>COPYRIGHT 2022 Springer</rights><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c541t-8c1cd8ce96d66400cfc803b428d3db321a0e4d1124ac56e45dd0f18d9f43ed6f3</citedby><cites>FETCH-LOGICAL-c541t-8c1cd8ce96d66400cfc803b428d3db321a0e4d1124ac56e45dd0f18d9f43ed6f3</cites><orcidid>0000-0002-9717-5231 ; 0000-0001-6721-0684 ; 0000-0002-9125-1889</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00436-022-07514-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00436-022-07514-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35435512$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Skariah, Sini</creatorcontrib><creatorcontrib>Sultan, Ali A.</creatorcontrib><creatorcontrib>Mordue, Dana G.</creatorcontrib><title>IFN-induced cell-autonomous immune mechanisms in the control of intracellular protozoa</title><title>Parasitology research (1987)</title><addtitle>Parasitol Res</addtitle><addtitle>Parasitol Res</addtitle><description>Vertebrate cells have evolved an elaborate multi-tiered intracellular surveillance system linked to downstream antimicrobial effectors to defend themselves from pathogens. This cellular self-defense system is referred to as cell-autonomous immunity. A wide array of cell-autonomous mechanisms operates to control intracellular pathogens including protozoa such as
Toxoplasma gondii
. Cell-autonomous immunity consists of antimicrobial defenses that are constitutively active in cells and those that are inducible typically in response to host cell activation. The IFN family of cytokines is an important stimulator of inducible cell-autonomous immunity. There are several hundred interferon-stimulated genes (ISGs); many of them have known roles in inducible cell-autonomous immune mechanisms. The importance of IFN-γ activation of cell-autonomous immunity is evidenced by the fact that many intracellular pathogens have evolved a diversity of molecular mechanisms to inhibit activation of infected cells through the JAK-STAT pathway in response to IFN-γ. The goal of this review is to provide a broad framework for understanding the elaborate system of cell-autonomous immunity that acts as a first line of defense between a host and intracellular parasites.</description><subject>Biological response modifiers</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cell activation</subject><subject>Immunity, Innate</subject><subject>Immunology</subject><subject>Immunology and Host-Parasite Interactions - Review</subject><subject>Immunotherapy</subject><subject>Interferon</subject><subject>Interferon-gamma</subject><subject>Intracellular</subject><subject>Janus Kinases - metabolism</subject><subject>Medical Microbiology</subject><subject>Microbiology</subject><subject>Molecular modelling</subject><subject>Pathogens</subject><subject>Signal Transduction</subject><subject>STAT Transcription Factors</subject><subject>Surveillance equipment</subject><subject>Toxoplasma</subject><subject>γ-Interferon</subject><issn>0932-0113</issn><issn>1432-1955</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9Uk1v1DAUtBCILoU_wAFF4tJLyvNnkgtSVVGoVLWXwtXy2i-7rhJ7sRMk-PV12FLaCiEfbD3PjDzjIeQthWMK0HzIAIKrGhiroZFU1M0zsqKCs5p2Uj4nK-jKGSjlB-RVzjcAtFFCvCQHXAouJWUr8u387LL2wc0WXWVxGGozTzHEMc658uM4B6xGtFsTfB7LJFTTFisbw5TiUMW-TKZkFuI8mFTtUpzir2hekxe9GTK-udsPydezT9enX-qLq8_npycXtZWCTnVrqXWtxU45pQSA7W0LfC1Y67hbc0YNoHCUMmGsVCikc9DT1nW94OhUzw_Jx73ubl6P6Cwurxn0LvnRpJ86Gq8f3wS_1Zv4Q3cMlFCiCBzdCaT4fcY86dHnxY4JWCLQTEkGHDohC_T9E-hNnFMo9gpKcdFK3j1AbcyA2oc-LvksovqkAS6VbCgU1PE_UGU5HH1JF3tf5o8IbE-wKeacsL_3SEEvbdD7NujSBv27DboppHcP07mn_Pn-AuB7QC5XYYPpr6X_yN4CgmG_1Q</recordid><startdate>20220601</startdate><enddate>20220601</enddate><creator>Skariah, Sini</creator><creator>Sultan, Ali A.</creator><creator>Mordue, Dana G.</creator><general>Springer Berlin Heidelberg</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-9717-5231</orcidid><orcidid>https://orcid.org/0000-0001-6721-0684</orcidid><orcidid>https://orcid.org/0000-0002-9125-1889</orcidid></search><sort><creationdate>20220601</creationdate><title>IFN-induced cell-autonomous immune mechanisms in the control of intracellular protozoa</title><author>Skariah, Sini ; Sultan, Ali A. ; Mordue, Dana G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c541t-8c1cd8ce96d66400cfc803b428d3db321a0e4d1124ac56e45dd0f18d9f43ed6f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Biological response modifiers</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cell activation</topic><topic>Immunity, Innate</topic><topic>Immunology</topic><topic>Immunology and Host-Parasite Interactions - Review</topic><topic>Immunotherapy</topic><topic>Interferon</topic><topic>Interferon-gamma</topic><topic>Intracellular</topic><topic>Janus Kinases - metabolism</topic><topic>Medical Microbiology</topic><topic>Microbiology</topic><topic>Molecular modelling</topic><topic>Pathogens</topic><topic>Signal Transduction</topic><topic>STAT Transcription Factors</topic><topic>Surveillance equipment</topic><topic>Toxoplasma</topic><topic>γ-Interferon</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Skariah, Sini</creatorcontrib><creatorcontrib>Sultan, Ali A.</creatorcontrib><creatorcontrib>Mordue, Dana G.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Parasitology research (1987)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Skariah, Sini</au><au>Sultan, Ali A.</au><au>Mordue, Dana G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>IFN-induced cell-autonomous immune mechanisms in the control of intracellular protozoa</atitle><jtitle>Parasitology research (1987)</jtitle><stitle>Parasitol Res</stitle><addtitle>Parasitol Res</addtitle><date>2022-06-01</date><risdate>2022</risdate><volume>121</volume><issue>6</issue><spage>1559</spage><epage>1571</epage><pages>1559-1571</pages><issn>0932-0113</issn><eissn>1432-1955</eissn><abstract>Vertebrate cells have evolved an elaborate multi-tiered intracellular surveillance system linked to downstream antimicrobial effectors to defend themselves from pathogens. This cellular self-defense system is referred to as cell-autonomous immunity. A wide array of cell-autonomous mechanisms operates to control intracellular pathogens including protozoa such as
Toxoplasma gondii
. Cell-autonomous immunity consists of antimicrobial defenses that are constitutively active in cells and those that are inducible typically in response to host cell activation. The IFN family of cytokines is an important stimulator of inducible cell-autonomous immunity. There are several hundred interferon-stimulated genes (ISGs); many of them have known roles in inducible cell-autonomous immune mechanisms. The importance of IFN-γ activation of cell-autonomous immunity is evidenced by the fact that many intracellular pathogens have evolved a diversity of molecular mechanisms to inhibit activation of infected cells through the JAK-STAT pathway in response to IFN-γ. The goal of this review is to provide a broad framework for understanding the elaborate system of cell-autonomous immunity that acts as a first line of defense between a host and intracellular parasites.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>35435512</pmid><doi>10.1007/s00436-022-07514-7</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0002-9717-5231</orcidid><orcidid>https://orcid.org/0000-0001-6721-0684</orcidid><orcidid>https://orcid.org/0000-0002-9125-1889</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0932-0113 |
| ispartof | Parasitology research (1987), 2022-06, Vol.121 (6), p.1559-1571 |
| issn | 0932-0113 1432-1955 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9206464 |
| source | MEDLINE; SpringerLink Journals |
| subjects | Biological response modifiers Biomedical and Life Sciences Biomedicine Cell activation Immunity, Innate Immunology Immunology and Host-Parasite Interactions - Review Immunotherapy Interferon Interferon-gamma Intracellular Janus Kinases - metabolism Medical Microbiology Microbiology Molecular modelling Pathogens Signal Transduction STAT Transcription Factors Surveillance equipment Toxoplasma γ-Interferon |
| title | IFN-induced cell-autonomous immune mechanisms in the control of intracellular protozoa |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-09T00%3A48%3A24IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=IFN-induced%20cell-autonomous%20immune%20mechanisms%20in%20the%20control%20of%20intracellular%20protozoa&rft.jtitle=Parasitology%20research%20(1987)&rft.au=Skariah,%20Sini&rft.date=2022-06-01&rft.volume=121&rft.issue=6&rft.spage=1559&rft.epage=1571&rft.pages=1559-1571&rft.issn=0932-0113&rft.eissn=1432-1955&rft_id=info:doi/10.1007/s00436-022-07514-7&rft_dat=%3Cgale_pubme%3EA703565710%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2663485395&rft_id=info:pmid/35435512&rft_galeid=A703565710&rfr_iscdi=true |