Unravelling innervation of pancreatic islets
The central and peripheral nervous systems play critical roles in regulating pancreatic islet function and glucose metabolism. Over the last century, in vitro and in vivo studies along with examination of human pancreas samples have revealed the structure of islet innervation, investigated the contr...
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| Veröffentlicht in: | Diabetologia 2022-07, Vol.65 (7), p.1069-1084 |
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| container_title | Diabetologia |
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| creator | Hampton, Rollie F. Jimenez-Gonzalez, Maria Stanley, Sarah A. |
| description | The central and peripheral nervous systems play critical roles in regulating pancreatic islet function and glucose metabolism. Over the last century, in vitro and in vivo studies along with examination of human pancreas samples have revealed the structure of islet innervation, investigated the contribution of sympathetic, parasympathetic and sensory neural pathways to glucose control, and begun to determine how the structure and function of pancreatic nerves are disrupted in metabolic disease. Now, state-of-the art techniques such as 3D imaging of pancreatic innervation and targeted in vivo neuromodulation provide further insights into the anatomy and physiological roles of islet innervation. Here, we provide a summary of the published work on the anatomy of pancreatic islet innervation, its roles, and evidence for disordered islet innervation in metabolic disease. Finally, we discuss the possibilities offered by new technologies to increase our knowledge of islet innervation and its contributions to metabolic regulation.
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| doi_str_mv | 10.1007/s00125-022-05691-9 |
| format | Article |
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Graphical abstract</description><subject>Anatomy</subject><subject>Anatomy & physiology</subject><subject>Glucose</subject><subject>Glucose metabolism</subject><subject>Human Physiology</subject><subject>Humans</subject><subject>Innervation</subject><subject>Internal Medicine</subject><subject>Islets of Langerhans - metabolism</subject><subject>Islets of Langerhans Transplantation</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic Diseases</subject><subject>Metabolic disorders</subject><subject>Metabolism</subject><subject>Nervous system</subject><subject>Neuromodulation</subject><subject>Pancreas</subject><subject>Parasympathetic nervous system</subject><subject>Pathogenesis</subject><subject>Review</subject><subject>Structure-function relationships</subject><issn>0012-186X</issn><issn>1432-0428</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kUtLAzEUhYMotlb_gAspuHHh6M1rMtkIUnyB4MaCu5CZSeqUaaYmMwX_valT62PhKlzOd09ychA6xnCBAcRlAMCEJ0BIAjyVOJE7aIgZjSMj2S4arvUEZ-nLAB2EMAcAylm6jwaUU5ZlBIbofOq8Xpm6rtxsXDln_Eq3VePGjR0vtSu8iWMxrkJt2nCI9qyugznanCM0vb15ntwnj093D5Prx6RggrUJxTkYrq3m2lhGSK6FlNZQjDUDaVmOJbZlKpkQpc5xWgpZpBZyXVgmyjKnI3TV-y67fGHKwrjW61otfbXQ_l01ulK_FVe9qlmzUpIA54JHg7ONgW_eOhNatahCEVNqZ5ouKJIyJhnBkkX09A86bzrvYrxICSowZLA2JD1V-CYEb-z2MRjUugzVl6FiGeqzDCXj0snPGNuVr9-PAO2BECU3M_777n9sPwDhHJW4</recordid><startdate>20220701</startdate><enddate>20220701</enddate><creator>Hampton, Rollie F.</creator><creator>Jimenez-Gonzalez, Maria</creator><creator>Stanley, Sarah A.</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-3285-6957</orcidid><orcidid>https://orcid.org/0000-0002-7678-9058</orcidid><orcidid>https://orcid.org/0000-0002-0253-2663</orcidid></search><sort><creationdate>20220701</creationdate><title>Unravelling innervation of pancreatic islets</title><author>Hampton, Rollie F. ; 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| subjects | Anatomy Anatomy & physiology Glucose Glucose metabolism Human Physiology Humans Innervation Internal Medicine Islets of Langerhans - metabolism Islets of Langerhans Transplantation Medicine Medicine & Public Health Metabolic Diseases Metabolic disorders Metabolism Nervous system Neuromodulation Pancreas Parasympathetic nervous system Pathogenesis Review Structure-function relationships |
| title | Unravelling innervation of pancreatic islets |
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