Lactate enhanced-quick Sequential Organ Failure Assessment 2 (LqSOFA2): A new score for bedside prognostication of patients with sepsis
Early diagnosis and prompt treatment remain a challenge in sepsis. To study the role of quick Sequential Organ Failure Assessment (qSOFA), blood lactate levels and a new score Lactate - Enhanced-qSOFA 2 (LqSOFA2) in predicting outcome in patients with sepsis and their association with established se...
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| Veröffentlicht in: | Indian Journal of Medical Research 2021-10, Vol.154 (4), p.607-614 |
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| container_title | Indian Journal of Medical Research |
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| creator | Daga, Mradul Kumar Rohatgi, Ishan Mishra, Rashmi Kumar, Naresh Mawari, Govind Mishra, T K Singh, Shashank Shukla, Jitendra |
| description | Early diagnosis and prompt treatment remain a challenge in sepsis. To study the role of quick Sequential Organ Failure Assessment (qSOFA), blood lactate levels and a new score Lactate - Enhanced-qSOFA 2 (LqSOFA2) in predicting outcome in patients with sepsis and their association with established severity scores.
This was a prospective, observational study in patients admitted to ICU of a tertiary care hospital in north India. qSOFA, Acute Physiology and Chronic Health Evaluation II (APACHE II), SOFA score and LqSOFA2 were calculated in 150 patients with sepsis. Measurements of lactate and SOFA score was done on days one, three and seven.
The mean arterial pressure (MAP) was significantly higher in survivors (70.14±19.54 vs. 48.53±26.86). The mean qSOFA significantly predicted mortality (1.81 vs. 2.63; P |
| doi_str_mv | 10.4103/ijmr.IJMR_319_20 |
| format | Article |
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This was a prospective, observational study in patients admitted to ICU of a tertiary care hospital in north India. qSOFA, Acute Physiology and Chronic Health Evaluation II (APACHE II), SOFA score and LqSOFA2 were calculated in 150 patients with sepsis. Measurements of lactate and SOFA score was done on days one, three and seven.
The mean arterial pressure (MAP) was significantly higher in survivors (70.14±19.54 vs. 48.53±26.86). The mean qSOFA significantly predicted mortality (1.81 vs. 2.63; P<0.0001). The mean lactate on days one, three and seven in survivors were 2.27±0.91, 1.72±0.77 and 1.14±0.48, respectively, while it was 4.32±2.35, 3.57±2.28 and 2.13±1.22, respectively, in the non-survivor group (P<0.001). The new score LqSOFA2 also significantly predicted mortality between non survivors and survivors (3.52±0.71 vs. 2.37±0.91). There was a significant correlation of qSOFA with SOFA and APACHE II on day one. Lactate levels and SOFA correlated on all three days.
qSOFA, a novel score and lactate can independently predict mortality in patients with sepsis. They correlate with APACHE II and SOFA but fail to equilibrate with either. The combination score LqSOFA2 showed marginal (statistically insignificant) increase in predictive accuracy and specificity when compared to lactate or qSOFA alone. Early diagnosis by LqSOFA2 makes it a good standalone bedside prognostic marker.</description><identifier>ISSN: 0971-5916</identifier><identifier>EISSN: 0975-9174</identifier><identifier>DOI: 10.4103/ijmr.IJMR_319_20</identifier><identifier>PMID: 35435346</identifier><language>eng</language><publisher>India: Wolters Kluwer - Medknow</publisher><subject>Humans ; Intensive Care Units ; Lactic Acid ; Organ Dysfunction Scores ; Original ; Prognosis ; Prospective Studies ; Retrospective Studies ; ROC Curve ; Sepsis - diagnosis</subject><ispartof>Indian Journal of Medical Research, 2021-10, Vol.154 (4), p.607-614</ispartof><rights>Copyright: © 2022 Indian Journal of Medical Research 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c396t-504afd9d5689b230a797ea1264690f49a0c9117a964089946502c47d1cdd54ba3</citedby><cites>FETCH-LOGICAL-c396t-504afd9d5689b230a797ea1264690f49a0c9117a964089946502c47d1cdd54ba3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9205011/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9205011/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35435346$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Daga, Mradul Kumar</creatorcontrib><creatorcontrib>Rohatgi, Ishan</creatorcontrib><creatorcontrib>Mishra, Rashmi</creatorcontrib><creatorcontrib>Kumar, Naresh</creatorcontrib><creatorcontrib>Mawari, Govind</creatorcontrib><creatorcontrib>Mishra, T K</creatorcontrib><creatorcontrib>Singh, Shashank</creatorcontrib><creatorcontrib>Shukla, Jitendra</creatorcontrib><title>Lactate enhanced-quick Sequential Organ Failure Assessment 2 (LqSOFA2): A new score for bedside prognostication of patients with sepsis</title><title>Indian Journal of Medical Research</title><addtitle>Indian J Med Res</addtitle><description>Early diagnosis and prompt treatment remain a challenge in sepsis. To study the role of quick Sequential Organ Failure Assessment (qSOFA), blood lactate levels and a new score Lactate - Enhanced-qSOFA 2 (LqSOFA2) in predicting outcome in patients with sepsis and their association with established severity scores.
This was a prospective, observational study in patients admitted to ICU of a tertiary care hospital in north India. qSOFA, Acute Physiology and Chronic Health Evaluation II (APACHE II), SOFA score and LqSOFA2 were calculated in 150 patients with sepsis. Measurements of lactate and SOFA score was done on days one, three and seven.
The mean arterial pressure (MAP) was significantly higher in survivors (70.14±19.54 vs. 48.53±26.86). The mean qSOFA significantly predicted mortality (1.81 vs. 2.63; P<0.0001). The mean lactate on days one, three and seven in survivors were 2.27±0.91, 1.72±0.77 and 1.14±0.48, respectively, while it was 4.32±2.35, 3.57±2.28 and 2.13±1.22, respectively, in the non-survivor group (P<0.001). The new score LqSOFA2 also significantly predicted mortality between non survivors and survivors (3.52±0.71 vs. 2.37±0.91). There was a significant correlation of qSOFA with SOFA and APACHE II on day one. Lactate levels and SOFA correlated on all three days.
qSOFA, a novel score and lactate can independently predict mortality in patients with sepsis. They correlate with APACHE II and SOFA but fail to equilibrate with either. The combination score LqSOFA2 showed marginal (statistically insignificant) increase in predictive accuracy and specificity when compared to lactate or qSOFA alone. Early diagnosis by LqSOFA2 makes it a good standalone bedside prognostic marker.</description><subject>Humans</subject><subject>Intensive Care Units</subject><subject>Lactic Acid</subject><subject>Organ Dysfunction Scores</subject><subject>Original</subject><subject>Prognosis</subject><subject>Prospective Studies</subject><subject>Retrospective Studies</subject><subject>ROC Curve</subject><subject>Sepsis - diagnosis</subject><issn>0971-5916</issn><issn>0975-9174</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVUU1v1DAUtBCIlsKdE_KxPaT4M6k5IK0qFooWrUThbL21nV2XxM76JVT8Av42WVqqcnojvZl5ozeEvObsXHEm38abvpxfff7y1UpurGBPyDEzja4Mb9TTv5hX2vD6iLxAvGGMG9GY5-RIaiW1VPUx-b0CN8IYaEg7SC74aj9F94Neh_0U0hiho-uyhUSXELupBLpADIj9vKOCnq721-vlQpy9owuawi1Fl2dOmwvdBI_RBzqUvE0Zx-hgjDnR3NJhRrMe6W0cdxTDgBFfkmctdBhe3c8T8n354dvlp2q1_nh1uVhVTpp6rDRT0HrjdX1hNkIyaEwTgIta1Ya1ygBzhvMGTK3YhTGq1kw41XjuvNdqA_KEvL_zHaZNH7ybcxTo7FBiD-WXzRDt_5sUd3abf1ojmGaczwan9wYlzy_C0fYRXeg6SCFPaEWtBZNcigOV3VFdyYgltA9nOLOH_uyhP_uov1ny5nG8B8G_wuQfoniZyQ</recordid><startdate>20211001</startdate><enddate>20211001</enddate><creator>Daga, Mradul Kumar</creator><creator>Rohatgi, Ishan</creator><creator>Mishra, Rashmi</creator><creator>Kumar, Naresh</creator><creator>Mawari, Govind</creator><creator>Mishra, T K</creator><creator>Singh, Shashank</creator><creator>Shukla, Jitendra</creator><general>Wolters Kluwer - Medknow</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20211001</creationdate><title>Lactate enhanced-quick Sequential Organ Failure Assessment 2 (LqSOFA2): A new score for bedside prognostication of patients with sepsis</title><author>Daga, Mradul Kumar ; Rohatgi, Ishan ; Mishra, Rashmi ; Kumar, Naresh ; Mawari, Govind ; Mishra, T K ; Singh, Shashank ; Shukla, Jitendra</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c396t-504afd9d5689b230a797ea1264690f49a0c9117a964089946502c47d1cdd54ba3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Humans</topic><topic>Intensive Care Units</topic><topic>Lactic Acid</topic><topic>Organ Dysfunction Scores</topic><topic>Original</topic><topic>Prognosis</topic><topic>Prospective Studies</topic><topic>Retrospective Studies</topic><topic>ROC Curve</topic><topic>Sepsis - diagnosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Daga, Mradul Kumar</creatorcontrib><creatorcontrib>Rohatgi, Ishan</creatorcontrib><creatorcontrib>Mishra, Rashmi</creatorcontrib><creatorcontrib>Kumar, Naresh</creatorcontrib><creatorcontrib>Mawari, Govind</creatorcontrib><creatorcontrib>Mishra, T K</creatorcontrib><creatorcontrib>Singh, Shashank</creatorcontrib><creatorcontrib>Shukla, Jitendra</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Indian Journal of Medical Research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Daga, Mradul Kumar</au><au>Rohatgi, Ishan</au><au>Mishra, Rashmi</au><au>Kumar, Naresh</au><au>Mawari, Govind</au><au>Mishra, T K</au><au>Singh, Shashank</au><au>Shukla, Jitendra</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lactate enhanced-quick Sequential Organ Failure Assessment 2 (LqSOFA2): A new score for bedside prognostication of patients with sepsis</atitle><jtitle>Indian Journal of Medical Research</jtitle><addtitle>Indian J Med Res</addtitle><date>2021-10-01</date><risdate>2021</risdate><volume>154</volume><issue>4</issue><spage>607</spage><epage>614</epage><pages>607-614</pages><issn>0971-5916</issn><eissn>0975-9174</eissn><abstract>Early diagnosis and prompt treatment remain a challenge in sepsis. To study the role of quick Sequential Organ Failure Assessment (qSOFA), blood lactate levels and a new score Lactate - Enhanced-qSOFA 2 (LqSOFA2) in predicting outcome in patients with sepsis and their association with established severity scores.
This was a prospective, observational study in patients admitted to ICU of a tertiary care hospital in north India. qSOFA, Acute Physiology and Chronic Health Evaluation II (APACHE II), SOFA score and LqSOFA2 were calculated in 150 patients with sepsis. Measurements of lactate and SOFA score was done on days one, three and seven.
The mean arterial pressure (MAP) was significantly higher in survivors (70.14±19.54 vs. 48.53±26.86). The mean qSOFA significantly predicted mortality (1.81 vs. 2.63; P<0.0001). The mean lactate on days one, three and seven in survivors were 2.27±0.91, 1.72±0.77 and 1.14±0.48, respectively, while it was 4.32±2.35, 3.57±2.28 and 2.13±1.22, respectively, in the non-survivor group (P<0.001). The new score LqSOFA2 also significantly predicted mortality between non survivors and survivors (3.52±0.71 vs. 2.37±0.91). There was a significant correlation of qSOFA with SOFA and APACHE II on day one. Lactate levels and SOFA correlated on all three days.
qSOFA, a novel score and lactate can independently predict mortality in patients with sepsis. They correlate with APACHE II and SOFA but fail to equilibrate with either. The combination score LqSOFA2 showed marginal (statistically insignificant) increase in predictive accuracy and specificity when compared to lactate or qSOFA alone. Early diagnosis by LqSOFA2 makes it a good standalone bedside prognostic marker.</abstract><cop>India</cop><pub>Wolters Kluwer - Medknow</pub><pmid>35435346</pmid><doi>10.4103/ijmr.IJMR_319_20</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Humans Intensive Care Units Lactic Acid Organ Dysfunction Scores Original Prognosis Prospective Studies Retrospective Studies ROC Curve Sepsis - diagnosis |
| title | Lactate enhanced-quick Sequential Organ Failure Assessment 2 (LqSOFA2): A new score for bedside prognostication of patients with sepsis |
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