A Small Molecule Stabilizes the Disordered Native State of the Alzheimer’s Aβ Peptide

The stabilization of native states of proteins is a powerful drug discovery strategy. It is still unclear, however, whether this approach can be applied to intrinsically disordered proteins. Here, we report a small molecule that stabilizes the native state of the Aβ42 peptide, an intrinsically disor...

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Veröffentlicht in:	ACS chemical neuroscience 2022-06, Vol.13 (12), p.1738-1745
Hauptverfasser:	Löhr, Thomas, Kohlhoff, Kai, Heller, Gabriella T., Camilloni, Carlo, Vendruscolo, Michele
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - drug therapy Alzheimer Disease - metabolism Amyloid beta-Peptides - metabolism Entropy Humans Intrinsically Disordered Proteins - metabolism Peptide Fragments - metabolism
Online-Zugang:	Volltext
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