Fine-Tuning Cardiac Insulin-Like Growth Factor 1 Receptor Signaling to Promote Health and Longevity

The insulin-like growth factor 1 (IGF1) pathway is a key regulator of cellular metabolism and aging. Although its inhibition promotes longevity across species, the effect of attenuated IGF1 signaling on cardiac aging remains controversial. We performed a lifelong study to assess cardiac health and l...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 2022-06, Vol.145 (25), p.1853-1866
Hauptverfasser:	Abdellatif, Mahmoud, Trummer-Herbst, Viktoria, Heberle, Alexander Martin, Humnig, Alina, Pendl, Tobias, Durand, Sylvère, Cerrato, Giulia, Hofer, Sebastian J., Islam, Moydul, Voglhuber, Julia, Ramos Pittol, José Miguel, Kepp, Oliver, Hoefler, Gerald, Schmidt, Albrecht, Rainer, Peter P., Scherr, Daniel, von Lewinski, Dirk, Bisping, Egbert, McMullen, Julie R., Diwan, Abhinav, Eisenberg, Tobias, Madeo, Frank, Thedieck, Kathrin, Kroemer, Guido, Sedej, Simon
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Animals Health Promotion Humans Insulin-Like Growth Factor I - metabolism Life Sciences Longevity Male Mice Myocytes, Cardiac - metabolism Original s Phosphatidylinositol 3-Kinases - metabolism Receptor, IGF Type 1 - genetics Receptor, IGF Type 1 - metabolism
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