The Skp2 Pathway: A Critical Target for Cancer Therapy

Strictly regulated protein degradation by ubiquitin-proteasome system (UPS) is essential for various cellular processes whose dysregulation is linked to serious diseases including cancer. Skp2, a well characterized component of Skp2-SCF E3 ligase complex, is able to conjugate both K48-linked ubiquit...

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Veröffentlicht in:	Seminars in cancer biology 2020-12, Vol.67 (Pt 2), p.16-33
Hauptverfasser:	Cai, Zhen, Moten, Asad, Peng, Danni, Hsu, Che-Chia, Pan, Bo-Syong, Manne, Rajeshkumar, Li, Hong-yu, Lin, Hui-Kuan
Format:	Artikel
Sprache:	eng
Schlagworte:	cancer targeting Skp2-SCF complex ubiquitination
Online-Zugang:	Volltext
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