Telomerase Reverse Transcriptase Expression Marks a Population of Rare Adipose Tissue Stem Cells

In adult tissues such as adipose tissue, post-mitotic cells like adipocytes can be replaced by differentiation of a population of tissue-resident stem cells. Expression of mouse telomerase reverse transcriptase (mTert) is a hallmark of stem cell populations, and previous efforts to identify tissue-r...

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Veröffentlicht in:	Stem cells (Dayton, Ohio) Ohio), 2022-03, Vol.40 (1), p.102-111
Hauptverfasser:	Lynes, Matthew D, Carlone, Diana L, Townsend, Kristy L, Breault, David T, Tseng, Yu-Hua
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipogenesis - genetics Adipose Tissue - metabolism Animals Cell Differentiation Mice Stem Cells - metabolism Telomerase - genetics Telomerase - metabolism Tissue-Specific Stem Cells
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Zusammenfassung:	In adult tissues such as adipose tissue, post-mitotic cells like adipocytes can be replaced by differentiation of a population of tissue-resident stem cells. Expression of mouse telomerase reverse transcriptase (mTert) is a hallmark of stem cell populations, and previous efforts to identify tissue-resident adult stem cells by measuring mTert expression have increased our understanding of stem cell biology significantly. Here, we used a doxycycline-inducible mouse model to perform longitudinal, live-animal lineage-tracing of mTert-expressing cells for more than 1 year. We identified a rare (
ISSN:	1066-5099 1549-4918
DOI:	10.1093/stmcls/sxab005