An Interplay of Multiple Positive and Negative Factors Governs Methicillin Resistance in Staphylococcus aureus
The development of resistance to β-lactam antibiotics has made Staphylococcus aureus a clinical burden on a global scale. MRSA (methicillin-resistant S. aureus) is commonly known as a superbug. The ability of MRSA to proliferate in the presence of β-lactams is attributed to the acquisition of , whic...
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| Veröffentlicht in: | Microbiology and molecular biology reviews 2022-06, Vol.86 (2), p.e0015921 |
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| container_title | Microbiology and molecular biology reviews |
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| creator | Bilyk, Bohdan L Panchal, Viralkumar V Tinajero-Trejo, Mariana Hobbs, Jamie K Foster, Simon J |
| description | The development of resistance to β-lactam antibiotics has made Staphylococcus aureus a clinical burden on a global scale. MRSA (methicillin-resistant S. aureus) is commonly known as a superbug. The ability of MRSA to proliferate in the presence of β-lactams is attributed to the acquisition of
, which encodes the alternative penicillin binding protein, PBP2A, which is insensitive to the antibiotics. Most MRSA isolates exhibit low-level β-lactam resistance, whereby additional genetic adjustments are required to develop high-level resistance. Although several genetic factors that potentiate or are required for high-level resistance have been identified, how these interact at the mechanistic level has remained elusive. Here, we discuss the development of resistance and assess the role of the associated components in tailoring physiology to accommodate incoming
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| doi_str_mv | 10.1128/mmbr.00159-21 |
| format | Article |
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, which encodes the alternative penicillin binding protein, PBP2A, which is insensitive to the antibiotics. Most MRSA isolates exhibit low-level β-lactam resistance, whereby additional genetic adjustments are required to develop high-level resistance. Although several genetic factors that potentiate or are required for high-level resistance have been identified, how these interact at the mechanistic level has remained elusive. Here, we discuss the development of resistance and assess the role of the associated components in tailoring physiology to accommodate incoming
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, which encodes the alternative penicillin binding protein, PBP2A, which is insensitive to the antibiotics. Most MRSA isolates exhibit low-level β-lactam resistance, whereby additional genetic adjustments are required to develop high-level resistance. Although several genetic factors that potentiate or are required for high-level resistance have been identified, how these interact at the mechanistic level has remained elusive. Here, we discuss the development of resistance and assess the role of the associated components in tailoring physiology to accommodate incoming
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, which encodes the alternative penicillin binding protein, PBP2A, which is insensitive to the antibiotics. Most MRSA isolates exhibit low-level β-lactam resistance, whereby additional genetic adjustments are required to develop high-level resistance. Although several genetic factors that potentiate or are required for high-level resistance have been identified, how these interact at the mechanistic level has remained elusive. Here, we discuss the development of resistance and assess the role of the associated components in tailoring physiology to accommodate incoming
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| source | American Society for Microbiology; MEDLINE; PubMed Central |
| subjects | Amides Anti-Bacterial Agents - therapeutic use Antibiotic resistance Antibiotics Antimicrobial Chemotherapy Bacterial Proteins - genetics Bacterial Proteins - metabolism Drug resistance Genetic factors Humans Methicillin Methicillin Resistance - genetics Methicillin-Resistant Staphylococcus aureus - genetics Penicillin Penicillin-Binding Proteins - genetics Penicillin-Binding Proteins - metabolism Resistance factors Review Staphylococcal Infections - drug therapy Staphylococcus aureus Staphylococcus aureus - genetics β-Lactam antibiotics |
| title | An Interplay of Multiple Positive and Negative Factors Governs Methicillin Resistance in Staphylococcus aureus |
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