Central tolerance is impaired in the middle‐aged thymic environment

One of the earliest hallmarks of immune aging is thymus involution, which not only reduces the number of newly generated and exported T cells, but also alters the composition and organization of the thymus microenvironment. Thymic T‐cell export continues into adulthood, yet the impact of thymus invo...

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Veröffentlicht in:	Aging cell 2022-06, Vol.21 (6), p.e13624-n/a
Hauptverfasser:	Lancaster, Jessica N., Keatinge‐Clay, Damaris E., Srinivasan, Jayashree, Li, Yu, Selden, Hilary J., Nam, Seohee, Richie, Ellen R., Ehrlich, Lauren I. R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Antigen-presenting cells Antigen-Presenting Cells - metabolism Antigens Autoantigens Autoantigens - metabolism Avidity cellular immunology Central Tolerance Clonal selection Dendritic cells Epithelial cells Epithelial Cells - metabolism immune aging Immunological tolerance Lymphocytes Lymphocytes T Microenvironments Middle age Motility Negative selection T cell T-Lymphocytes, Regulatory Thymocytes Thymus Thymus Gland thymus involution
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