Prevalence and Correlates of Vitamin A Insufficiency Among 12–18-Month-Old Children Living in Slums of Mumbai, India
We aimed to determine the prevalence of baseline vitamin A insufficiency (VAI; serum retinol (SR) < 1.05μmol/L) and to identify potential correlates of SR and VAI in a population of 12–18-month-old children participating in a randomized controlled trial in urban slums in Mumbai, India. In this cr...
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| Veröffentlicht in: | Current developments in nutrition 2022-06, Vol.6 (Supplement_1), p.580-580 |
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| creator | Jones, Camille Huey, Samantha Finkelstein, Julia Venkatramanan, Sudha Udipi, Shoba Thakker, Varsha Thorat, Aparna Potdar, Ramesh Chopra, Harsha Haas, Jere Mehta, Saurabh |
| description | We aimed to determine the prevalence of baseline vitamin A insufficiency (VAI; serum retinol (SR) < 1.05μmol/L) and to identify potential correlates of SR and VAI in a population of 12–18-month-old children participating in a randomized controlled trial in urban slums in Mumbai, India.
In this cross-sectional analysis, we determined SR concentrations in archived serum samples (N = 118) that were collected from 12–18-month-old children in urban slum communities of Western Mumbai in March–October 2017. We adjusted SR measurements using the BRINDA adjustment method for C-reactive protein.1 Child, maternal and household characteristics were assessed as potential correlates. Linear [β(SE)] and binomial [RR (95% CI)] regressions were used to identify correlates of SR and VAI, respectively. Age and sex were retained in all models.
The children in this population had a median (IQR) age of 14.5 (12.4, 16.7) months, and 46.6% were girls. Almost a third (27.1%) were underweight (weight-for-age Z-score |
| doi_str_mv | 10.1093/cdn/nzac060.038 |
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In this cross-sectional analysis, we determined SR concentrations in archived serum samples (N = 118) that were collected from 12–18-month-old children in urban slum communities of Western Mumbai in March–October 2017. We adjusted SR measurements using the BRINDA adjustment method for C-reactive protein.1 Child, maternal and household characteristics were assessed as potential correlates. Linear [β(SE)] and binomial [RR (95% CI)] regressions were used to identify correlates of SR and VAI, respectively. Age and sex were retained in all models.
The children in this population had a median (IQR) age of 14.5 (12.4, 16.7) months, and 46.6% were girls. Almost a third (27.1%) were underweight (weight-for-age Z-score <-2) and 9.3% were wasted (weight-for-length Z-score <-2). One third (30.5%) were anemic (hemoglobin < 11g/dL) and 19.5% of children were zinc-deficient (Zn < 70μg/dL). Median (IQR) unadjusted SR was 1.1 (0.9, 1.4) μmol/L and VAI was present among 50 (42.4%) of the population. After adjusting for inflammation, SR was 1.2 (1.0, 1.5) μmol/L and VAI was present in 38 (32.2%) of children. In multivariate regressions, each nmol/L increase in vitamin D [25(OH)D] was associated with a 0.01 μmol/L increase in SR [β (SE) 0.01 (0.004), p = 0.004], and each additional child under 5 years living in the household was associated with lower SR [–0.13 (0.04), p = 0.003].
In these 12–18-month-old children, VAI was prevalent in nearly two out of every five children.
Division of Nutritional Sciences, Cornell University Harvest Plus.</description><identifier>ISSN: 2475-2991</identifier><identifier>EISSN: 2475-2991</identifier><identifier>DOI: 10.1093/cdn/nzac060.038</identifier><language>eng</language><publisher>Elsevier Inc</publisher><subject>Global Nutrition</subject><ispartof>Current developments in nutrition, 2022-06, Vol.6 (Supplement_1), p.580-580</ispartof><rights>2022 American Society for Nutrition.</rights><rights>The Author 2022. Published by Oxford University Press on behalf of The International Society for Human and Animal Mycology. 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9193946/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9193946/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,1598,27903,27904,53769,53771</link.rule.ids></links><search><creatorcontrib>Jones, Camille</creatorcontrib><creatorcontrib>Huey, Samantha</creatorcontrib><creatorcontrib>Finkelstein, Julia</creatorcontrib><creatorcontrib>Venkatramanan, Sudha</creatorcontrib><creatorcontrib>Udipi, Shoba</creatorcontrib><creatorcontrib>Thakker, Varsha</creatorcontrib><creatorcontrib>Thorat, Aparna</creatorcontrib><creatorcontrib>Potdar, Ramesh</creatorcontrib><creatorcontrib>Chopra, Harsha</creatorcontrib><creatorcontrib>Haas, Jere</creatorcontrib><creatorcontrib>Mehta, Saurabh</creatorcontrib><title>Prevalence and Correlates of Vitamin A Insufficiency Among 12–18-Month-Old Children Living in Slums of Mumbai, India</title><title>Current developments in nutrition</title><description>We aimed to determine the prevalence of baseline vitamin A insufficiency (VAI; serum retinol (SR) < 1.05μmol/L) and to identify potential correlates of SR and VAI in a population of 12–18-month-old children participating in a randomized controlled trial in urban slums in Mumbai, India.
In this cross-sectional analysis, we determined SR concentrations in archived serum samples (N = 118) that were collected from 12–18-month-old children in urban slum communities of Western Mumbai in March–October 2017. We adjusted SR measurements using the BRINDA adjustment method for C-reactive protein.1 Child, maternal and household characteristics were assessed as potential correlates. Linear [β(SE)] and binomial [RR (95% CI)] regressions were used to identify correlates of SR and VAI, respectively. Age and sex were retained in all models.
The children in this population had a median (IQR) age of 14.5 (12.4, 16.7) months, and 46.6% were girls. Almost a third (27.1%) were underweight (weight-for-age Z-score <-2) and 9.3% were wasted (weight-for-length Z-score <-2). One third (30.5%) were anemic (hemoglobin < 11g/dL) and 19.5% of children were zinc-deficient (Zn < 70μg/dL). Median (IQR) unadjusted SR was 1.1 (0.9, 1.4) μmol/L and VAI was present among 50 (42.4%) of the population. After adjusting for inflammation, SR was 1.2 (1.0, 1.5) μmol/L and VAI was present in 38 (32.2%) of children. In multivariate regressions, each nmol/L increase in vitamin D [25(OH)D] was associated with a 0.01 μmol/L increase in SR [β (SE) 0.01 (0.004), p = 0.004], and each additional child under 5 years living in the household was associated with lower SR [–0.13 (0.04), p = 0.003].
In these 12–18-month-old children, VAI was prevalent in nearly two out of every five children.
Division of Nutritional Sciences, Cornell University Harvest Plus.</description><subject>Global Nutrition</subject><issn>2475-2991</issn><issn>2475-2991</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>TOX</sourceid><recordid>eNqNkMtKAzEYRgdRsNSu3WYtTptkZprJRijFS6GlgpdtyOTSRmaSkrlAXfkOvqFPYmyL6EJwlR_ynbM4UXSO4BBBmoyEtCP7ygUcwyFM8qOoh1OSxZhSdPzjPo0Gdf0CIUSU0jGkvai796rjpbJCAW4lmDrvVckbVQOnwbNpeGUsmICZrVutjTBhuQWTytkVQPjj7R3l8cLZZh0vy0CvTSm9smBuOhMWAX0o22rnWrRVwc1lMEnDz6ITzctaDQ5vP3q6uX6c3sXz5e1sOpnHAuNgTlNCpM4zJDmhOE8ELSjOBJUpQUISREiaFQVPc62hxkRSnowznRccF7xQIk_60dXeu2mLSkmhbON5yTbeVNxvmeOG_f6xZs1WrmMU0YSm4yAY7QXCu7r2Sn-zCLKv9CykZ4f0LKQPxMWecO3mH2O6H6sQoTPKs3qXWEnjlWiYdOZP9hPNq5zt</recordid><startdate>202206</startdate><enddate>202206</enddate><creator>Jones, Camille</creator><creator>Huey, Samantha</creator><creator>Finkelstein, Julia</creator><creator>Venkatramanan, Sudha</creator><creator>Udipi, Shoba</creator><creator>Thakker, Varsha</creator><creator>Thorat, Aparna</creator><creator>Potdar, Ramesh</creator><creator>Chopra, Harsha</creator><creator>Haas, Jere</creator><creator>Mehta, Saurabh</creator><general>Elsevier Inc</general><general>Oxford University Press</general><scope>6I.</scope><scope>AAFTH</scope><scope>TOX</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>202206</creationdate><title>Prevalence and Correlates of Vitamin A Insufficiency Among 12–18-Month-Old Children Living in Slums of Mumbai, India</title><author>Jones, Camille ; Huey, Samantha ; Finkelstein, Julia ; Venkatramanan, Sudha ; Udipi, Shoba ; Thakker, Varsha ; Thorat, Aparna ; Potdar, Ramesh ; Chopra, Harsha ; Haas, Jere ; Mehta, Saurabh</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2218-4477df851da79283c9b925c9d471cd717745bba48ff0f27d9a365f8ba2babec83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Global Nutrition</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jones, Camille</creatorcontrib><creatorcontrib>Huey, Samantha</creatorcontrib><creatorcontrib>Finkelstein, Julia</creatorcontrib><creatorcontrib>Venkatramanan, Sudha</creatorcontrib><creatorcontrib>Udipi, Shoba</creatorcontrib><creatorcontrib>Thakker, Varsha</creatorcontrib><creatorcontrib>Thorat, Aparna</creatorcontrib><creatorcontrib>Potdar, Ramesh</creatorcontrib><creatorcontrib>Chopra, Harsha</creatorcontrib><creatorcontrib>Haas, Jere</creatorcontrib><creatorcontrib>Mehta, Saurabh</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Oxford Journals Open Access Collection</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Current developments in nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jones, Camille</au><au>Huey, Samantha</au><au>Finkelstein, Julia</au><au>Venkatramanan, Sudha</au><au>Udipi, Shoba</au><au>Thakker, Varsha</au><au>Thorat, Aparna</au><au>Potdar, Ramesh</au><au>Chopra, Harsha</au><au>Haas, Jere</au><au>Mehta, Saurabh</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prevalence and Correlates of Vitamin A Insufficiency Among 12–18-Month-Old Children Living in Slums of Mumbai, India</atitle><jtitle>Current developments in nutrition</jtitle><date>2022-06</date><risdate>2022</risdate><volume>6</volume><issue>Supplement_1</issue><spage>580</spage><epage>580</epage><pages>580-580</pages><issn>2475-2991</issn><eissn>2475-2991</eissn><abstract>We aimed to determine the prevalence of baseline vitamin A insufficiency (VAI; serum retinol (SR) < 1.05μmol/L) and to identify potential correlates of SR and VAI in a population of 12–18-month-old children participating in a randomized controlled trial in urban slums in Mumbai, India.
In this cross-sectional analysis, we determined SR concentrations in archived serum samples (N = 118) that were collected from 12–18-month-old children in urban slum communities of Western Mumbai in March–October 2017. We adjusted SR measurements using the BRINDA adjustment method for C-reactive protein.1 Child, maternal and household characteristics were assessed as potential correlates. Linear [β(SE)] and binomial [RR (95% CI)] regressions were used to identify correlates of SR and VAI, respectively. Age and sex were retained in all models.
The children in this population had a median (IQR) age of 14.5 (12.4, 16.7) months, and 46.6% were girls. Almost a third (27.1%) were underweight (weight-for-age Z-score <-2) and 9.3% were wasted (weight-for-length Z-score <-2). One third (30.5%) were anemic (hemoglobin < 11g/dL) and 19.5% of children were zinc-deficient (Zn < 70μg/dL). Median (IQR) unadjusted SR was 1.1 (0.9, 1.4) μmol/L and VAI was present among 50 (42.4%) of the population. After adjusting for inflammation, SR was 1.2 (1.0, 1.5) μmol/L and VAI was present in 38 (32.2%) of children. In multivariate regressions, each nmol/L increase in vitamin D [25(OH)D] was associated with a 0.01 μmol/L increase in SR [β (SE) 0.01 (0.004), p = 0.004], and each additional child under 5 years living in the household was associated with lower SR [–0.13 (0.04), p = 0.003].
In these 12–18-month-old children, VAI was prevalent in nearly two out of every five children.
Division of Nutritional Sciences, Cornell University Harvest Plus.</abstract><pub>Elsevier Inc</pub><doi>10.1093/cdn/nzac060.038</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Global Nutrition |
| title | Prevalence and Correlates of Vitamin A Insufficiency Among 12–18-Month-Old Children Living in Slums of Mumbai, India |
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