Alternative strategies for the synthesis of [11C]ER176 for PET imaging of neuroinflammation

[11C]ER176 is a next generation PET radioligand for imaging 18 kDa translocator protein, a biomarker for neuroinflammation. The goal of this work was to investigate alternative strategies for the radiochemical synthesis, purification, and formulation of [11C]ER176. An optimized tri-solvent high-perf...

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Veröffentlicht in:	Applied radiation and isotopes 2021-12, Vol.178, p.109954-109954, Article 109954
Hauptverfasser:	Mixdorf, Jason C., Murali, Dhanabalan, Xin, Yangchun, DiFilippo, Alexandra H., Aluicio-Sarduy, Eduardo, Barnhart, Todd E., Engle, Jonathan W., Ellison, Paul A., Christian, Bradley T.
Format:	Artikel
Sprache:	eng
Schlagworte:	11-Carbon Carbon Radioisotopes - chemistry Chromatography, High Pressure Liquid ER176 Humans Neuroinflammation Neuroinflammatory Diseases - diagnostic imaging PET Positron-Emission Tomography - methods Quality Control Radiochemistry Radiopharmaceuticals - administration & dosage Radiopharmaceuticals - chemical synthesis Solid Phase Extraction Spectrophotometry, Ultraviolet TSPO
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