Discovery and Mechanism of Small Molecule Inhibitors Selective for the Chromatin-Binding Domains of Oncogenic UHRF1

Chromatin abnormalities are common hallmarks of cancer cells, which exhibit alterations in DNA methylation profiles that can silence tumor suppressor genes. These epigenetic patterns are partly established and maintained by UHRF1 (ubiquitin-like PHD and RING finger domain-containing protein 1), whic...

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Veröffentlicht in:	Biochemistry (Easton) 2022-03, Vol.61 (5), p.354-366
Hauptverfasser:	Liu, Wallace H, Miner, 3rd, Robert E, Albaugh, Brittany N, Ananiev, Gene E, Wildman, Scott A, Denu, John M
Format:	Artikel
Sprache:	eng
Schlagworte:	Carcinogenesis CCAAT-Enhancer-Binding Proteins - metabolism Chromatin DNA Methylation Histones - metabolism Humans Ubiquitin-Protein Ligases - metabolism
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