Reduced electron transport chain complex I protein abundance and function in Mfn2‐deficient myogenic progenitors lead to oxidative stress and mitochondria swelling

Mitochondrial remodeling through fusion and fission is crucial for progenitor cell differentiation but its role in myogenesis is poorly understood. Here, we characterized the function of mitofusin 2 (Mfn2), a mitochondrial outer membrane protein critical for mitochondrial fusion, in muscle progenito...

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Veröffentlicht in:	The FASEB journal 2021-04, Vol.35 (4), p.e21426-n/a
Hauptverfasser:	Luo, Nanjian, Yue, Feng, Jia, Zhihao, Chen, Jingjuan, Deng, Qing, Zhao, Yongju, Kuang, Shihuan
Format:	Artikel
Sprache:	eng
Schlagworte:	Mfn2 mitochondrion myogenesis myogenic progenitor cells oxidative respiration
Online-Zugang:	Volltext
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