Glioma progression is shaped by genetic evolution and microenvironment interactions

The factors driving therapy resistance in diffuse glioma remain poorly understood. To identify treatment-associated cellular and genetic changes, we analyzed RNA and/or DNA sequencing data from the temporally separated tumor pairs of 304 adult patients with isocitrate dehydrogenase (IDH)-wild-type a...

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Veröffentlicht in:	Cell 2022-06, Vol.185 (12), p.2184-2199.e16
Hauptverfasser:	Varn, Frederick S., Johnson, Kevin C., Martinek, Jan, Huse, Jason T., Wesseling, Pieter, Cooper, Lee A.D., Malta, Tathiane M., Wade, Taylor E., Brat, Daniel, Aldape, Kenneth, Ismail, Azzam, Kim, Hoon, White, Kieron, Pollock, Steven, Goldfarb, Christine, Lee, Ga-Hyun, Anderson, Kevin J., Nehar-Belaid, Djamel, Bakas, Spyridon, Byrne, Annette T., D’Angelo, Fulvio, Gan, Hui K., Khasraw, Mustafa, Migliozzi, Simona, Paek, Sun Ha, Walenkamp, Annemiek M.E., Weiss, Tobias, Poisson, Laila M., Noushmehr, Houtan, Iavarone, Antonio, Verhaak, Roel G.W., Nasrallah, MacLean P., Sabedot, Thais S., Gould, Peter V., Sivajothi, Santhosh K., Barthel, Floris P., Kocakavuk, Emre, Ahmed, Nazia, Moon, Hyo-Eun, Garofano, Luciano, Barnholtz-Sloan, Jill S., Ryan Ormond, D., Ha Paek, Sun, Van Meir, Erwin G., Watts, Colin, Weller, Michael, Amin, Samirkumar B., Brodbelt, Andrew, Bulsara, Ketan R., Castro, Ana Valeria, Connelly, Jennifer M., Costello, Joseph F., Finocchiaro, Gaetano, French, Pim J., Hau, Ann C., Hong, Chibo, Horbinski, Craig, Kannan, Kasthuri S., Kouwenhoven, Mathilde CM, LaViolette, Peter S., Ligon, Keith L., Lowman, Allison K., Miletic, Hrvoje, Niers, Johanna M., Phillips, Joanna J., Rabadan, Raul, Rao, Ganesh, Reifenberger, Guido, Sanai, Nader, Short, Susan C., Suzuki, Hiromichi, Tabatabai, Ghazaleh, Tomaszewski, William H., Wells, Michael, Wheeler, Helen, Xie, Jichun, Alfred Yung, W.K., Zadeh, Gelareh, Verhaak, Roel GW
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult adults Brain Neoplasms - genetics Brain Neoplasms - pathology disease progression DNA evolution Evolution, Molecular Genes, p16 genomics glioblastoma glioma Glioma - genetics Glioma - pathology histology Humans hypermutation isocitrate dehydrogenase Isocitrate Dehydrogenase - genetics macrophages microenvironment Mutation Neoplasm Recurrence, Local neurons RNA single-cell spatial imaging therapeutics treatment resistance Tumor Microenvironment
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