A novelly designed protein antagonist confers potent neutralization against SARS-CoV-2 variants of concern

A novelly designed protein antagonist confers potent neutralization against SARS-CoV-2 variants of concern

nNovel designed protein antagonist Kansetin shows ultra-high affinity to SARS-CoV-2nKansetin exhibits broad-spectrum neutralization of SARS-CoV-2 variants of concernnKansetin has promising in vivo efficacy and non-observable toxicitynKansetin provides barely reduced potency during long-term high-tem...

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Veröffentlicht in:The Journal of infection 2022-09, Vol.85 (3), p.e72-e76
Hauptverfasser: Lv, Panjing, Hu, Bing, Hua, Rong, Zhang, Jun, Zhang, Haoran, Liu, Zhang, Xu, Liqiong, He, Zhen, Li, Xiang, Guo, Ming, Pan, Kai, Zhang, Zhen, Zeng, Qili, Wu, Zhi, Sun, Li, Guo, Meng, Zhou, Li, Xu, Xiuzhen, Yu, Bo, Xu, Junqiang, Yuan, Shuai, Guo, Min, Cai, Kun, Xia, Yuchen, Li, Yan
Format: Artikel
Sprache:eng
Schlagworte:
ACE2
Broad-spectrum neutralization
De novo design
Letter to the Editor
Omicron
Protein antagonist
SARS-CoV-2
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Zusammenfassung:nNovel designed protein antagonist Kansetin shows ultra-high affinity to SARS-CoV-2nKansetin exhibits broad-spectrum neutralization of SARS-CoV-2 variants of concernnKansetin has promising in vivo efficacy and non-observable toxicitynKansetin provides barely reduced potency during long-term high-temperature storage
ISSN:0163-4453
1532-2742
DOI:10.1016/j.jinf.2022.06.001